Journal ArticleDOI
Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics.
Kaili Lin,Lunguo Xia,Haiyan Li,Xinquan Jiang,Haobo Pan,Yuanjin Xu,William W. Lu,Zhiyuan Zhang,Jiang Chang +8 more
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TLDR
In vivo experiments revealed that SrCS dramatically stimulated bone regeneration and angiogenesis in a critical sized OVX calvarial defect model, and the enhanced bone regeneration might be attributed to the modulation of osteogenic differentiation of endogenous mesenchymal stem cells (MSCs) and the inhibition of osteoclastogenesis, accompanying with the promotion of the angiogenic activity of endothelial cells (ECs).About:
This article is published in Biomaterials.The article was published on 2013-12-01. It has received 295 citations till now. The article focuses on the topics: Bone regeneration & Bone resorption.read more
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Nanostructured monticellite: An emerging player in tissue engineering
Erfan Kalantari,Seyed Morteza Naghib,M. Reza Naimi-Jamal,Rezvan Esmaeili,Keivan Majidzadeh-A,Keivan Majidzadeh-A,Masoud Mozafari +6 more
TL;DR: In this paper, a novel calcium silicate bioceramic (monticellite) was synthesized by sol-gel method and heat-treated at low temperature (1350°C).
Journal ArticleDOI
Strontium-Substituted Dicalcium Silicate Bone Cements with Enhanced Osteogenesis Potential for Orthopaedic Applications.
TL;DR: The Sr-C2S bone cements possessed good in vitro bioactivity by inducing apatite formation in simulated body fluid (SBF) within 7 days and might be a bioactive self-setting material with enhanced biological performance and holds the prospect for application in the bone regeneration area.
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Immunohistochemical evaluation after Sr-enriched biphasic ceramic implantation in rabbits femoral neck: comparison of seven different bone conditions
TL;DR: It is concluded that Sr-enriched biomaterials induce higher potential to improve bone regeneration than pure bioceramics in constant osteoporosis of femoral neck bone.
Journal ArticleDOI
Does Local Application of Strontium Increase Osteogenesis and Biomaterial Osteointegration in Osteoporotic and Other Bone Tissue Conditions: Review of Literature
TL;DR: An overview about strontium, its mechanisms of action in bone tissue and initiated changes of bone remodeling within biomaterials is provided.
Journal ArticleDOI
Polymeric coating on β-TCP scaffolds provides immobilization of small extracellular vesicles with surface-functionalization and ZEB1-Loading for bone defect repair in diabetes mellitus
Amy C. Mulligan,sindurrlpp +1 more
TL;DR: In this paper , a hyaluronic acid (HA)/poly-L-lysine (PLL) layer-by-layer self-assembly coating on β-TCP (β-tricalcium phosphate) scaffolds providing immobilization of modularized engineered sEVs (with RGDfC) surface functionalization and ZEB1 loading) to facilitate bone defect regeneration under DM conditions.
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Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Gary L. Johnson,Razvan Lapadat +1 more
TL;DR: Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes, and inhibitors of these enzymes are being explored as anticancer agents.
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Osteoporosis: now and the future
TL;DR: Novel treatment strategies have been developed that aim to inhibit excessive bone resorption and increase bone formation and the most promising novel treatments include denosumab, a monoclonal antibody for receptor activator of NF-κB ligand; odanacatib, a specific inhibitor of the osteoclast protease cathepsin K; and antibodies against the proteins sclerostin and dickkopf-1, two endogenous inhibitors of bone formation.
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The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis
Pierre J. Meunier,Christian Roux,Ego Seeman,Sergio Ortolani,J. Badurski,Tim D. Spector,J. Cannata,Adam Balogh,EM Lemmel,S. Pors-Nielsen,René Rizzoli,Harry K. Genant,Jean-Yves Reginster +12 more
TL;DR: Treatment of postmenopausal osteoporosis with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures.