Journal ArticleDOI
Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics.
Kaili Lin,Lunguo Xia,Haiyan Li,Xinquan Jiang,Haobo Pan,Yuanjin Xu,William W. Lu,Zhiyuan Zhang,Jiang Chang +8 more
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TLDR
In vivo experiments revealed that SrCS dramatically stimulated bone regeneration and angiogenesis in a critical sized OVX calvarial defect model, and the enhanced bone regeneration might be attributed to the modulation of osteogenic differentiation of endogenous mesenchymal stem cells (MSCs) and the inhibition of osteoclastogenesis, accompanying with the promotion of the angiogenic activity of endothelial cells (ECs).About:
This article is published in Biomaterials.The article was published on 2013-12-01. It has received 295 citations till now. The article focuses on the topics: Bone regeneration & Bone resorption.read more
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Materials design for bone-tissue engineering
TL;DR: In this paper, the authors provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modelling and treatment of injuries and disease in humans, and highlight scalable technologies that can fabricate natural and synthetic biomaterials (polymers, bioceramics, metals and composites) into forms suitable for bone tissue engineering applications in human therapies and disease models.
Journal ArticleDOI
Bone biomaterials and interactions with stem cells.
TL;DR: A comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells is presented and the promising seed stem cells for bone repair are summarized, and their interaction mechanisms are discussed in detail.
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Exosomes Secreted by Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Repair Critical-Sized Bone Defects through Enhanced Angiogenesis and Osteogenesis in Osteoporotic Rats.
TL;DR: It is demonstrated that the application of hiPSC-MSC-Exos+β-TCP scaffolds promoted bone regeneration in critical-sized calvarial defects by enhancing angiogenesis and osteogenesis in an ovariectomized rat model.
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The roles of ions on bone regeneration.
TL;DR: A review of recent literature has revealed that several ions are uniquely capable of inducing stem cell differentiation down desired lineages and there exists enormous promise for these ions to be used in bone regenerative medicine.
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The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration.
TL;DR: The results are the first to elucidate the specific effect of each ion from bioceramics on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration, paving the way for the design of functional biomaterials with complex compositions for tissue engineering and regenerative medicine.
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Journal ArticleDOI
Solubility of strontium-substituted apatite by solid titration.
TL;DR: Strontium-substituted HAp might be usable as a template for the growth of new bone, since nucleation appears to be facilitated and solubility increased with increasing strontium content.
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The enhancement of bone regeneration by a combination of osteoconductivity and osteostimulation using β-CaSiO3/β-Ca3(PO4)2 composite bioceramics.
TL;DR: The findings indicated that the degradation rate and bioactivity ofβ-CS/β-TCP composite bioceramic scaffolds could be adjusted by controlling the ratio of β-CS to β- TCP, suggesting the potential application of β -CS/ β-TCp composite biOCeramical scaffolds with 50 and 80 wt.% β- CS component in hard tissue regeneration and bone tissue engineering.
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Blood vessel formation in the tissue-engineered bone with the constitutively active form of HIF-1α mediated BMSCs.
Duohong Zou,Zhiyuan Zhang,Jiacai He,Kai Zhang,Dongxia Ye,Wei Han,Jian Zhou,Yuanyin Wang,Quanli Li,Xin Liu,Xin Zhang,Shaoyi Wang,Jingzhou Hu,Chao Zhu,Wenjie Zhang,Yong Zhou,Honghai Fu,Yuanliang Huang,Xinquan Jiang +18 more
TL;DR: Improved understanding of the mechanisms of angiogenesis may offer exciting therapeutic opportunities for vascularization, vascular remodeling, and bone defect repair using tissue engineering strategies in the future.
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Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model
Zhuo Wang,James C.H. Goh,Shamal Das De,Zigang Ge,Hongwei Ouyang,Jeniffer Sue Wee Chong,Siew Leng Low,Eng Hin Lee +7 more
TL;DR: It is suggested that transplantation of MSCs into sites at risk for developing osteoporotic bone could improve bone structure and biomechanics in rabbits and help to strengthen osteoblast bone in rabbits.
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The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: involvement of osteoprotegerin.
Songlin Peng,X. Sherry Liu,Shishu Huang,Zhaoyang Li,Haobo Pan,Wanxin Zhen,Keith D. K. Luk,X. Edward Guo,William W. Lu +8 more
TL;DR: The evidences from the in vitro and in vivo studies suggested that OPG played an important role in the uncoupling effect of Sr on bone metabolism, possibly by acting as a cross-talk molecule between osteoclasts and osteoblasts in response to Sr treatment.