Journal ArticleDOI
Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics.
Kaili Lin,Lunguo Xia,Haiyan Li,Xinquan Jiang,Haobo Pan,Yuanjin Xu,William W. Lu,Zhiyuan Zhang,Jiang Chang +8 more
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TLDR
In vivo experiments revealed that SrCS dramatically stimulated bone regeneration and angiogenesis in a critical sized OVX calvarial defect model, and the enhanced bone regeneration might be attributed to the modulation of osteogenic differentiation of endogenous mesenchymal stem cells (MSCs) and the inhibition of osteoclastogenesis, accompanying with the promotion of the angiogenic activity of endothelial cells (ECs).About:
This article is published in Biomaterials.The article was published on 2013-12-01. It has received 295 citations till now. The article focuses on the topics: Bone regeneration & Bone resorption.read more
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Mechanically reinforced injectable bioactive nanocomposite hydrogels for in-situ bone regeneration
TL;DR: In this article , a novel injectable organic-inorganic nanocomposite GelMA hydrogel system doped with Sr-substituted xonotlite (Sr-CSH) nanofibers was developed.
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Hierarchical porous hydroxyapatite fibers with a hollow structure as drug delivery carriers
TL;DR: In this article, hierarchical porous hydroxyapatite fibers with a hollow structure were fabricated using a facile ion exchange approach using a bioglass fiber as hard template after the composite fibers were fabricated as precursor with electrospinning method.
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Substituted hydroxyapatite: a recent development
Yu Jiang,Zhiyu Yuan,Jie Huang +2 more
TL;DR: In this review, the recent development on substituted HA was overviewed from the aspects of enhanced osteoconductivity and multifunctionality of mono- and multi-cationic and anionic substitutions.
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Sr-doped nanowire modification of Ca-Si-based coatings for improved osteogenic activities and reduced inflammatory reactions.
TL;DR: The Sr-doped nanowire modification may be a valuable approach to enhance osteogenic activities and reduce inflammatory reactions.
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Synthesis and characterization of novel mesoporous strontium-modified bioactive glass nanospheres for bone tissue engineering applications
Amir Hossein Taghvaei,Forough Danaeifar,Christoph Gammer,Jürgen Eckert,Jürgen Eckert,Sadjad Khosravimelal,Mazaher Gholipourmalekabadi +6 more
TL;DR: In this article, a template assisted sol-gel process was used to synthesize mesoporous bioactive glass nanoparticles (MBNs) with high textural properties, including specific surface area (408-480m2/g) and pore volume (0.54-0.62 cm3/g).
References
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Journal ArticleDOI
The biology of VEGF and its receptors.
TL;DR: Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions and is implicated in pathologicalAngiogenesis associated with tumors, intraocular neovascular disorders and other conditions.
Journal ArticleDOI
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.
Gray W. Pearson,Fred L. Robinson,Tara Beers Gibson,Bing E. Xu,Mahesh Karandikar,Kevin S. Berman,Melanie H. Cobb +6 more
TL;DR: Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted and particular emphasis is on ERK1/2.
Journal ArticleDOI
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Gary L. Johnson,Razvan Lapadat +1 more
TL;DR: Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes, and inhibitors of these enzymes are being explored as anticancer agents.
Journal ArticleDOI
Osteoporosis: now and the future
TL;DR: Novel treatment strategies have been developed that aim to inhibit excessive bone resorption and increase bone formation and the most promising novel treatments include denosumab, a monoclonal antibody for receptor activator of NF-κB ligand; odanacatib, a specific inhibitor of the osteoclast protease cathepsin K; and antibodies against the proteins sclerostin and dickkopf-1, two endogenous inhibitors of bone formation.
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The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis
Pierre J. Meunier,Christian Roux,Ego Seeman,Sergio Ortolani,J. Badurski,Tim D. Spector,J. Cannata,Adam Balogh,EM Lemmel,S. Pors-Nielsen,René Rizzoli,Harry K. Genant,Jean-Yves Reginster +12 more
TL;DR: Treatment of postmenopausal osteoporosis with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures.