Journal ArticleDOI
Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics.
Kaili Lin,Lunguo Xia,Haiyan Li,Xinquan Jiang,Haobo Pan,Yuanjin Xu,William W. Lu,Zhiyuan Zhang,Jiang Chang +8 more
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TLDR
In vivo experiments revealed that SrCS dramatically stimulated bone regeneration and angiogenesis in a critical sized OVX calvarial defect model, and the enhanced bone regeneration might be attributed to the modulation of osteogenic differentiation of endogenous mesenchymal stem cells (MSCs) and the inhibition of osteoclastogenesis, accompanying with the promotion of the angiogenic activity of endothelial cells (ECs).About:
This article is published in Biomaterials.The article was published on 2013-12-01. It has received 295 citations till now. The article focuses on the topics: Bone regeneration & Bone resorption.read more
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Materials design for bone-tissue engineering
TL;DR: In this paper, the authors provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modelling and treatment of injuries and disease in humans, and highlight scalable technologies that can fabricate natural and synthetic biomaterials (polymers, bioceramics, metals and composites) into forms suitable for bone tissue engineering applications in human therapies and disease models.
Journal ArticleDOI
Bone biomaterials and interactions with stem cells.
TL;DR: A comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells is presented and the promising seed stem cells for bone repair are summarized, and their interaction mechanisms are discussed in detail.
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Exosomes Secreted by Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Repair Critical-Sized Bone Defects through Enhanced Angiogenesis and Osteogenesis in Osteoporotic Rats.
TL;DR: It is demonstrated that the application of hiPSC-MSC-Exos+β-TCP scaffolds promoted bone regeneration in critical-sized calvarial defects by enhancing angiogenesis and osteogenesis in an ovariectomized rat model.
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The roles of ions on bone regeneration.
TL;DR: A review of recent literature has revealed that several ions are uniquely capable of inducing stem cell differentiation down desired lineages and there exists enormous promise for these ions to be used in bone regenerative medicine.
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The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration.
TL;DR: The results are the first to elucidate the specific effect of each ion from bioceramics on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration, paving the way for the design of functional biomaterials with complex compositions for tissue engineering and regenerative medicine.
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Journal ArticleDOI
Osteopenic bone cell response to strontium-substituted hydroxyapatite.
TL;DR: Sr substitution increased the levels of proliferation, alkaline phosphatase, and collagen type I, and down-regulated the production of interleukin-6 of O-OB cells, demonstrating a promising future of SrHA in the treatment of bone lesions and defects in the presence of osteoporotic bone.
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Biological properties of VEGF/VPF receptors.
TL;DR: The purpose of this review is to summarize what is known concerning one aspect of the biology of VEGF/VPF, the interaction of the growth factor with its cell surface receptors.
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The use of autologous enriched bone marrow MSCs to enhance osteoporotic bone defect repair in long-term estrogen deficient goats.
Lei Cao,Guangwang Liu,Yaokai Gan,Qiming Fan,Fei Yang,Xiaoling Zhang,Tingting Tang,Kerong Dai +7 more
TL;DR: By combining autologous enriched bone marrow mesenchymal stem cells with porous β-TCP, this study successfully repaired critical-sized bone defects in the medial femoral condyle of the osteoporotic goats.
Journal ArticleDOI
Endothelial cell compatibility testing of three different Pellethanes.
Laurence Bordenave,Ch. Baquey,R. Bareille,F. Lefebvre,C. Lauroua,V. Guérin,F. Rouais,N. More,Ch. Vergnes,J. M. Anderson +9 more
TL;DR: Plelethane 75 D could be the best support for in vitro endothelization with an inhibition of proliferation for both 55 D and 75 D types (compared to the control), and a functional monolayer of ECs was obtained on 75 D.
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In vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cells
Songlin Peng,Xiaowei Sherry Liu,Ting Wang,Zhaoyang Li,Guangqian Zhou,Keith D. K. Luk,Xiangdong Edward Guo,William W. Lu +7 more
TL;DR: This study suggests that the anabolic effect of Sr on normal or osteoporotic bones is associated with increased osteoblastic differentiation of BMSCs.