Journal ArticleDOI
Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics.
Kaili Lin,Lunguo Xia,Haiyan Li,Xinquan Jiang,Haobo Pan,Yuanjin Xu,William W. Lu,Zhiyuan Zhang,Jiang Chang +8 more
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TLDR
In vivo experiments revealed that SrCS dramatically stimulated bone regeneration and angiogenesis in a critical sized OVX calvarial defect model, and the enhanced bone regeneration might be attributed to the modulation of osteogenic differentiation of endogenous mesenchymal stem cells (MSCs) and the inhibition of osteoclastogenesis, accompanying with the promotion of the angiogenic activity of endothelial cells (ECs).About:
This article is published in Biomaterials.The article was published on 2013-12-01. It has received 295 citations till now. The article focuses on the topics: Bone regeneration & Bone resorption.read more
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Effect of ethanol/TEOS ratios and amount of ammonia on the properties of copper-doped calcium silicate nanoceramics
Georgia K. Pouroutzidou,Georgios S. Theodorou,Eleana Kontonasaki,Ioannis Tsamesidis,Antonella Pantaleo,Dimitra Patsiaoura,Lambrini Papadopoulou,Jonathan Rhoades,Eleni Likotrafiti,Christos B. Lioutas,Konstantinos Chrissafis,Konstantinos M. Paraskevopoulos +11 more
TL;DR: The aim of the present work was the evaluation of the effect of different ratios of Ethanol/TEOS and total amount of the inserted ammonia to the particle size, morphology and bioactive, hemolytic and antibacterial behavior of nanoparticles in the quaternary system SiO2–CaO–MgO–CuO.
Journal ArticleDOI
Amorphous carbon modification on implant surface: a general strategy to enhance osteogenic differentiation for diverse biomaterials via FAK/ERK1/2 signaling pathways.
Xinran Zhang,Xinran Zhang,Haotian Li,Jiaqiang Liu,Hui Wang,Wenjun Sun,Kaili Lin,Xudong Wang,Steve Guofang Shen +8 more
TL;DR: The results suggest that the approach involving modifying a surface with amorphous carbon provides a general and simple strategy to enhance the osteogenesis for diverse biomaterials, and this has promising potential for bone repairing applications.
Journal ArticleDOI
Induction of VEGF secretion from bone marrow stromal cell line (ST-2) by the dissolution products of mesoporous silica glass particles containing CuO and SrO
Preethi Balasubramanian,Antonio J. Salinas,Sandra Sánchez-Salcedo,Rainer Detsch,María Vallet-Regí,Aldo R. Boccaccini +5 more
TL;DR: The combination of Cu2+ and Sr2+ lays the foundation for engineering a bioactive glass than can lead to vascularized, functional bone tissue when used in bone regeneration applications.
Journal ArticleDOI
Bone Tissue Engineering through 3D Bioprinting of Bioceramic Scaffolds: A Review and Update
Ahmad Taha Khalaf,Yuanyuan Wei,Jun Wan,Jiang Zhu,Yu Peng,Samiah Yasmin Abdul Kadir,Jamaludin Zainol,Zahraa Oglah,Lijia Cheng,Zheng Shi +9 more
TL;DR: The main principles and characteristics of the currently available methods in orthopedic bioprinting technology to prepare bioceramic scaffolds are reviewed, and the challenges and prospects for applications in this promising and vital field are discussed.
Journal ArticleDOI
Biomaterial based treatment of osteoclastic/osteoblastic cell imbalance – Gelatin-modified calcium/strontium phosphates
Benjamin Kruppke,Alena-Svenja Wagner,Marcus Rohnke,Christiane Heinemann,Claudia Kreschel,Annett Gebert,Hans-Peter Wiesmann,Sybille Mazurek,Sabine Wenisch,Thomas Hanke +9 more
TL;DR: The mixed gelatin-modified calcium/strontium phosphate allowed osteoclastogenesis as proven morphologically and by real-time quantitative polymerase chain reaction (RT-qPCR) and was precisely this material that led to the best osteoblastic reaction of human bone marrow stromal cells cultured on the material.
References
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Journal ArticleDOI
The biology of VEGF and its receptors.
TL;DR: Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions and is implicated in pathologicalAngiogenesis associated with tumors, intraocular neovascular disorders and other conditions.
Journal ArticleDOI
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.
Gray W. Pearson,Fred L. Robinson,Tara Beers Gibson,Bing E. Xu,Mahesh Karandikar,Kevin S. Berman,Melanie H. Cobb +6 more
TL;DR: Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted and particular emphasis is on ERK1/2.
Journal ArticleDOI
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Gary L. Johnson,Razvan Lapadat +1 more
TL;DR: Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes, and inhibitors of these enzymes are being explored as anticancer agents.
Journal ArticleDOI
Osteoporosis: now and the future
TL;DR: Novel treatment strategies have been developed that aim to inhibit excessive bone resorption and increase bone formation and the most promising novel treatments include denosumab, a monoclonal antibody for receptor activator of NF-κB ligand; odanacatib, a specific inhibitor of the osteoclast protease cathepsin K; and antibodies against the proteins sclerostin and dickkopf-1, two endogenous inhibitors of bone formation.
Journal ArticleDOI
The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis
Pierre J. Meunier,Christian Roux,Ego Seeman,Sergio Ortolani,J. Badurski,Tim D. Spector,J. Cannata,Adam Balogh,EM Lemmel,S. Pors-Nielsen,René Rizzoli,Harry K. Genant,Jean-Yves Reginster +12 more
TL;DR: Treatment of postmenopausal osteoporosis with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures.