Journal ArticleDOI
Enteric Glia Regulate Intestinal Barrier Function and Inflammation Via Release of S-Nitrosoglutathione
Tor C. Savidge,Tor C. Savidge,Paul Newman,Charalabos Pothoulakis,A. Ruhl,Michel Neunlist,Arnaud Bourreille,Roger D. Hurst,Michael V. Sofroniew +8 more
TLDR
Enteric glia share the ability of astrocytes to regulate tight-junction integrity, and cellular interactions comparable with those maintaining blood-brain barrier function also regulate epithelial permeability at mucosal surfaces.About:
This article is published in Gastroenterology.The article was published on 2007-04-01. It has received 362 citations till now. The article focuses on the topics: Barrier function.read more
Citations
More filters
Journal ArticleDOI
Astrocytes: biology and pathology
TL;DR: Astrocyte functions in healthy CNS, mechanisms and functions of reactive astrogliosis and glial scar formation, and ways in which reactive astrocytes may cause or contribute to specific CNS disorders and lesions are reviewed.
Journal ArticleDOI
The enteric nervous system and neurogastroenterology
TL;DR: This Review provides a broad overview of the field of neurogastroenterology, with a focus on the roles of the ENS in the control of the musculature of the gastrointestinal tract and transmucosal fluid movement.
Journal ArticleDOI
Protein S-nitrosylation in health and disease: a current perspective
TL;DR: Recent findings that implicate S-nitrosylation in cardiovascular, pulmonary, musculoskeletal and neurological (dys)function, as well as in cancer are reviewed.
The Enteric Nervous System
TL;DR: The Enteric nervous system is a type of central nervous system that controls the action of the autonomic nervous systems in animals and humans.
Journal ArticleDOI
Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators
Thierry Piche,Giovanni Barbara,Philippe Aubert,S. Bruley des Varannes,Raffaella Dainese,J L Nano,Cesare Cremon,Vincenzo Stanghellini,R. De Giorgio,J. P. Galmiche,Michel Neunlist +10 more
TL;DR: This study shows that colonic soluble mediators are able to reproduce functional (permeability) and molecular (ZO-1 mRNA expression) alterations observed in IBS patients, which might pave the way both to identify novel biomarkers as well as new therapeutic targets in Ibs.
References
More filters
Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
Journal ArticleDOI
The blood-brain barrier: an overview: structure, regulation, and clinical implications.
Praveen Ballabh,Alex Braun +1 more
TL;DR: The pathogenesis of increased BBB permeability in hypoxia-ischemia and inflammatory mechanisms involving the BBB in septic encephalopathy, HIV-induced dementia, multiple sclerosis, and Alzheimer disease are described.
Journal ArticleDOI
Astrocytes induce blood–brain barrier properties in endothelial cells
Robert C. Janzer,Martin Raff +1 more
TL;DR: Direct evidence is provided that astrocytes are capable of inducing blood–brain barrier properties in non-neural endothelial cells in vivo.
Journal ArticleDOI
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide.
Samie R. Jaffrey,Hediye Erdjument-Bromage,Christopher D. Ferris,Paul Tempst,Solomon H. Snyder +4 more
TL;DR: Protein S-nitrosylation is established as a physiological signalling mechanism for neuronally generated NO in mice harbouring a genomic deletion of neuronal NO synthase (nNOS).