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Essentials of Glycobiology
Ajit Varki,Richard D. Cummings,Jeffrey D. Esko,Hudson H. Freeze,Pamela Stanley,Carolyn R. Bertozzi,Gerald W. Hart,Marilynn E. Etzler +7 more
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TLDR
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function.Abstract:
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function - monosaccharide metabolism N-glycans O-glycans glycosphingolipids glycophospholipid anchors proteoglycans and glycosaminoglycans other classes of golgi-derived glycans nuclear and cytoplasmic glycosylation the O-GlcNAc modification sialic acids structures common to different types of glycans glycosyltransferases degradation and turnover of glycans glycosylation in "model" organisms glycobiology of plant cells bacterial polysaccharides proteins that recognize glycans - discovery and classification of animal lectins P-type lectins I-type lectins C-type lectins selectins S-type lectins (galectins) microbial glycan-binding proteins glycosaminoglycan-binding proteins plant lectins glycans in genetic disorders and disease - genetic disorders of glycosylation in cultured cells naturally occurring genetic disorders of glycosylation in animals determining glycan function using genetically modified mice glycosylation changes in ontogeny and cell activation glycosylation changes in cancer glycobiology of protozoal and helminthic parasites acquired glycosylation changes in human disease methods and applications - structural analysis and sequencing of glycans chemical and enzymatic synthesis of glycans natural and synthetic inhibitors of glycosylation glycobiology in biotechnology and medicine.read more
Citations
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Journal ArticleDOI
Galectin-3 plays a modulatory role in the life span and activation of murine neutrophils during early Toxoplasma gondii infection.
C M O S Alves,Deise A. O. Silva,Ana Elisa Caleiro Seixas Azzolini,Cleni Mara Marzocchi-Machado,Julianne V. Carvalho,Ana C. A. M. Pajuaba,Yara Maria Lucisano-Valim,Roger Chammas,Fu-Tong Liu,Maria Cristina Roque-Barreira,José Roberto Mineo +10 more
TL;DR: It is demonstrated that Gal-3 plays an important modulatory role by interfering in Nphi life span and activation during early T. gondii infection and suppresses PMA- but not zymosan-induced ROS generation inNphi following T. Gondii infections.
Journal ArticleDOI
Crystal Structures of β-1,4-Galactosyltransferase 7 Enzyme Reveal Conformational Changes and Substrate Binding
TL;DR: This study for the first time reveals the molecular interactions between a glycosyltransferase and its donor and acceptor substrates bound together in the same crystal structure and clearly suggests an SN2 type catalytic mechanism for the β4GalT7 enzyme.
Journal ArticleDOI
Novel mouse monoclonal antibodies specifically recognizing β-(1→3)-D-glucan antigen.
Andrey L. Matveev,Vadim B. Krylov,Yana A. Khlusevich,Ivan K. Baykov,D. V. Yashunsky,Ljudmila A. Emelyanova,Yury E. Tsvetkov,Alexander A. Karelin,Alevtina V. Bardashova,Sarah Sze Wah Wong,Vishukumar Aimanianda,Jean-Paul Latgé,Nina V. Tikunova,Nikolay E. Nifantiev +13 more
TL;DR: Immunolabelling indicated that 3G11 and 5H5 interact with both yeasts and filamentous fungi, including species from Aspergillus, Candida, Penicillium genera and Saccharomyces cerevisiae, but not bacteria, suggesting that these β-glucan-specific mAbs could be useful in combinatorial antifungal therapy.
Journal ArticleDOI
Polypeptide encoded by mouse ZP3 exon-7 is necessary and sufficient for binding of mouse sperm in vitro.
TL;DR: Observations provide new evidence that sperm recognize and bind to a region of mZP3 polypeptide immediately downstream of its ZP domain that is encoded by mZp3 exon‐7.
Journal ArticleDOI
Recognition of the Thomsen-Friedenreich Pancarcinoma Carbohydrate Antigen by a Lamprey Variable Lymphocyte Receptor
Ming Luo,Ming Luo,C. Alejandro Velikovsky,Xinbo Yang,Maqbool A. Siddiqui,Xia Hong,Joseph J. Barchi,Jeffrey C. Gildersleeve,Zeev Pancer,Roy A. Mariuzza +9 more
TL;DR: The crystal structure of a VLR-TFα complex coupled with thermodynamic analysis revealed the basis for selectivity and provided a template for engineering VLRs to bind biomedically relevant glycans, leading to the exquisite selectivity of VLRB.aGPA.23.
References
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Book ChapterDOI
Sialic Acids in Molecular and Cellular Interactions
Sørge Kelm,Roland Schauer +1 more
TL;DR: The aim of this chapter is to summarize the knowledge about Sias in masking, for example, galactose residues, and to review the progress made during the past few years with respect to Sias as recognition determinants in the adhesion of pathogenic viruses, bacteria, and protozoa, and particularly as binding sites for endogenous cellular interaction molecules.
Journal ArticleDOI
Structure, function and metabolism of sialic acids
C. Traving,Roland Schauer +1 more
TL;DR: Sialic acids represent a family of sugar molecules with an unusual and highly variable chemical structure that are found mostly in the terminal position of oligosaccharide chains on the surface of cells and molecules and their metabolism is looked at.