Open AccessBook
Essentials of Glycobiology
Ajit Varki,Richard D. Cummings,Jeffrey D. Esko,Hudson H. Freeze,Pamela Stanley,Carolyn R. Bertozzi,Gerald W. Hart,Marilynn E. Etzler +7 more
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TLDR
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function.Abstract:
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function - monosaccharide metabolism N-glycans O-glycans glycosphingolipids glycophospholipid anchors proteoglycans and glycosaminoglycans other classes of golgi-derived glycans nuclear and cytoplasmic glycosylation the O-GlcNAc modification sialic acids structures common to different types of glycans glycosyltransferases degradation and turnover of glycans glycosylation in "model" organisms glycobiology of plant cells bacterial polysaccharides proteins that recognize glycans - discovery and classification of animal lectins P-type lectins I-type lectins C-type lectins selectins S-type lectins (galectins) microbial glycan-binding proteins glycosaminoglycan-binding proteins plant lectins glycans in genetic disorders and disease - genetic disorders of glycosylation in cultured cells naturally occurring genetic disorders of glycosylation in animals determining glycan function using genetically modified mice glycosylation changes in ontogeny and cell activation glycosylation changes in cancer glycobiology of protozoal and helminthic parasites acquired glycosylation changes in human disease methods and applications - structural analysis and sequencing of glycans chemical and enzymatic synthesis of glycans natural and synthetic inhibitors of glycosylation glycobiology in biotechnology and medicine.read more
Citations
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Book ChapterDOI
Modulation of glycan recognition by clustered saccharide patches.
Miriam Cohen,Ajit Varki +1 more
TL;DR: This review focuses on a higher level of glycan organization, the formation of clustered saccharide patches (CSPs), which can constitute unique ligands for highly specific interactions, and presents a wealth of evidence for CSPs-mediated interactions.
Journal ArticleDOI
Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB)
TL;DR: Two RTB-specific neutralizing monoclonal IgG(1) antibodies, 24B11 and SylH3, were sufficient to protect the animals against a 5×LD(50) dose of ricin, raising the possibility of using specific RTB sub-domains, rather than RTB itself, as antigens to more efficiently elicit neutralizing antibodies and protective immunity against ricin.
Journal ArticleDOI
The minimum information required for a glycomics experiment (MIRAGE) project : sample preparation guidelines for reliable reporting of glycomics datasets
Weston B. Struwe,Sanjay Agravat,Kiyoko F. Aoki-Kinoshita,Matthew Campbell,Catherine E. Costello,Anne Dell,Ten Feizi,Stuart M. Haslam,Niclas G. Karlsson,Kay-Hooi Khoo,Daniel Kolarich,Yan Liu,Ryan McBride,Milos V. Novotny,Nicolle H. Packer,James C. Paulson,Erdmann Rapp,Rene Ranzinger,Pauline M. Rudd,David F. Smith,Michael Tiemeyer,Lance Wells,William S. York,Joseph Zaia,Carsten Kettner +24 more
TL;DR: The application of MIRAGE sample preparation guidelines will lead to improved recording of experimental protocols and reporting of understandable and reproducible glycomics datasets, as well as broadening of experimental techniques worldwide.
Journal ArticleDOI
N-Glycosylation of GABAA receptor subunits is altered in Schizophrenia.
TL;DR: It is suggested that disruptions of N-glycosylation in schizophrenia are not exclusive to glutamate and may indicate a potential disruption of a central cell signaling process in this disorder.
POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss
TL;DR: Goddeeris et al. as discussed by the authors showed that a homozygous missense D233E mutation in protein O-glucosyltransferase 1 (POGLUT1) dramatically reduces its enzymatic activity on Notch.
References
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Book ChapterDOI
Sialic Acids in Molecular and Cellular Interactions
Sørge Kelm,Roland Schauer +1 more
TL;DR: The aim of this chapter is to summarize the knowledge about Sias in masking, for example, galactose residues, and to review the progress made during the past few years with respect to Sias as recognition determinants in the adhesion of pathogenic viruses, bacteria, and protozoa, and particularly as binding sites for endogenous cellular interaction molecules.
Journal ArticleDOI
Structure, function and metabolism of sialic acids
C. Traving,Roland Schauer +1 more
TL;DR: Sialic acids represent a family of sugar molecules with an unusual and highly variable chemical structure that are found mostly in the terminal position of oligosaccharide chains on the surface of cells and molecules and their metabolism is looked at.