Open AccessBook
Essentials of Glycobiology
Ajit Varki,Richard D. Cummings,Jeffrey D. Esko,Hudson H. Freeze,Pamela Stanley,Carolyn R. Bertozzi,Gerald W. Hart,Marilynn E. Etzler +7 more
Reads0
Chats0
TLDR
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function.Abstract:
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function - monosaccharide metabolism N-glycans O-glycans glycosphingolipids glycophospholipid anchors proteoglycans and glycosaminoglycans other classes of golgi-derived glycans nuclear and cytoplasmic glycosylation the O-GlcNAc modification sialic acids structures common to different types of glycans glycosyltransferases degradation and turnover of glycans glycosylation in "model" organisms glycobiology of plant cells bacterial polysaccharides proteins that recognize glycans - discovery and classification of animal lectins P-type lectins I-type lectins C-type lectins selectins S-type lectins (galectins) microbial glycan-binding proteins glycosaminoglycan-binding proteins plant lectins glycans in genetic disorders and disease - genetic disorders of glycosylation in cultured cells naturally occurring genetic disorders of glycosylation in animals determining glycan function using genetically modified mice glycosylation changes in ontogeny and cell activation glycosylation changes in cancer glycobiology of protozoal and helminthic parasites acquired glycosylation changes in human disease methods and applications - structural analysis and sequencing of glycans chemical and enzymatic synthesis of glycans natural and synthetic inhibitors of glycosylation glycobiology in biotechnology and medicine.read more
Citations
More filters
Patent
Production of galactosylated glycoproteins in lower eukaryotes
Robert C. Davidson,Tillman U. Gerngross,Stefan Wildt,Byung-Kwon Choi,Juergen Hermann Nett,Piotr Bobrowicz,Stephen R. Hamilton +6 more
TL;DR: In this article, a lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal β-galactose residue and essentially lacking fucose and sialic acid residues.
Journal ArticleDOI
Visualizing enveloping layer glycans during zebrafish early embryogenesis.
TL;DR: An approach to the imaging of glycans that enables their visualization in the enveloping layer during the early stages of zebrafish embryogenesis is reported and provides a platform for imaging other biomolecular targets by microinjection of appropriately functionalized biosynthetic precursors.
Journal ArticleDOI
The immunoglobulin G1 N-glycan composition affects binding to each low affinity Fc γ receptor
Ganesh P. Subedi,Adam W. Barb +1 more
TL;DR: Binding of the extracellular Fc-binding domains for human CD16A and B, CD32A, B and C, and CD64 to 6 well-defined IgG1 Fc glycoforms are measured, suggesting the contributions of these residues to Fc γ receptor affinity are independent.
Journal ArticleDOI
A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation
Luigi Boccuto,Kazuhiro Aoki,Heather Flanagan-Steet,Chin-Fu Chen,Xiang Fan,Frank O. Bartel,Marharyta Petukh,Ayla R Pittman,Robert A. Saul,Alka Chaubey,Emil Alexov,Michael Tiemeyer,Richard Steet,Charles E. Schwartz +13 more
TL;DR: 'Salt & Pepper' syndrome is an autosomal recessive condition characterized by severe intellectual disability, epilepsy, scoliosis, choreoathetosis, dysmorphic facial features and altered dermal pigmentation, and whole-exome sequencing narrowed the candidate region to chromosome 2p11.
Journal ArticleDOI
Concept, strategy and realization of lectin-based glycan profiling.
TL;DR: Critical points concerning the use of lectins are described, together with the concept, strategy and means to achieve advances in these emerging glycan profiling technologies.
References
More filters
Book ChapterDOI
Sialic Acids in Molecular and Cellular Interactions
Sørge Kelm,Roland Schauer +1 more
TL;DR: The aim of this chapter is to summarize the knowledge about Sias in masking, for example, galactose residues, and to review the progress made during the past few years with respect to Sias as recognition determinants in the adhesion of pathogenic viruses, bacteria, and protozoa, and particularly as binding sites for endogenous cellular interaction molecules.
Journal ArticleDOI
Structure, function and metabolism of sialic acids
C. Traving,Roland Schauer +1 more
TL;DR: Sialic acids represent a family of sugar molecules with an unusual and highly variable chemical structure that are found mostly in the terminal position of oligosaccharide chains on the surface of cells and molecules and their metabolism is looked at.