Open AccessBook
Essentials of Glycobiology
Ajit Varki,Richard D. Cummings,Jeffrey D. Esko,Hudson H. Freeze,Pamela Stanley,Carolyn R. Bertozzi,Gerald W. Hart,Marilynn E. Etzler +7 more
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TLDR
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function.Abstract:
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function - monosaccharide metabolism N-glycans O-glycans glycosphingolipids glycophospholipid anchors proteoglycans and glycosaminoglycans other classes of golgi-derived glycans nuclear and cytoplasmic glycosylation the O-GlcNAc modification sialic acids structures common to different types of glycans glycosyltransferases degradation and turnover of glycans glycosylation in "model" organisms glycobiology of plant cells bacterial polysaccharides proteins that recognize glycans - discovery and classification of animal lectins P-type lectins I-type lectins C-type lectins selectins S-type lectins (galectins) microbial glycan-binding proteins glycosaminoglycan-binding proteins plant lectins glycans in genetic disorders and disease - genetic disorders of glycosylation in cultured cells naturally occurring genetic disorders of glycosylation in animals determining glycan function using genetically modified mice glycosylation changes in ontogeny and cell activation glycosylation changes in cancer glycobiology of protozoal and helminthic parasites acquired glycosylation changes in human disease methods and applications - structural analysis and sequencing of glycans chemical and enzymatic synthesis of glycans natural and synthetic inhibitors of glycosylation glycobiology in biotechnology and medicine.read more
Citations
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Journal ArticleDOI
Unusual sugar biosynthesis and natural product glycodiversification
TL;DR: Biochemical and structural studies of sugar biosynthetic enzymes and glycosyltransferases, coupled with advances in bioengineering methodology, have ushered in a new era of drug development.
Journal ArticleDOI
Sialic acid is an essential nutrient for brain development and cognition.
TL;DR: The evidence showing the importance of dietary Sia as an essential nutrient for brain development and cognition is summarized.
Journal ArticleDOI
Hypersialylation of β1 Integrins, Observed in Colon Adenocarcinoma, May Contribute to Cancer Progression by Up-regulating Cell Motility
Eric C. Seales,Gustavo Adolfo Jurado,Brian A. Brunson,John K. Wakefield,Andra R. Frost,Susan L. Bellis +5 more
TL;DR: Findings suggest that beta1 hypersialylation may augment colon tumor progression by altering cell preference for certain extracellular matrix milieus, as well as by stimulating cell migration.
Journal ArticleDOI
A new GROMOS force field for hexopyranose-based carbohydrates
TL;DR: A new parameter set (referred to as 45A4) is developed for the explicit‐solvent simulation of hexopyranose‐based carbohydrates and is validated for a limited set of monosaccharide and disaccharides in solution, by comparing the results of simulations to available experimental data.
Journal ArticleDOI
Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida.
Poh-Choo Pang,Philip C.N. Chiu,Cheuk-Lun Lee,Lan-Yi Chang,Maria Panico,Howard R. Morris,Stuart M. Haslam,Kay-Hooi Khoo,Gary F. Clark,William S.B. Yeung,Anne Dell +10 more
TL;DR: In this paper, the sialyl-Lewis(x) sequence [NeuAcα2-3Galβ1-4(Fucα1-3)GlcNAc], a well-known selectin ligand, is the most abundant terminal sequence on the N- and O-glycans of human ZP.
References
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Book ChapterDOI
Sialic Acids in Molecular and Cellular Interactions
Sørge Kelm,Roland Schauer +1 more
TL;DR: The aim of this chapter is to summarize the knowledge about Sias in masking, for example, galactose residues, and to review the progress made during the past few years with respect to Sias as recognition determinants in the adhesion of pathogenic viruses, bacteria, and protozoa, and particularly as binding sites for endogenous cellular interaction molecules.
Journal ArticleDOI
Structure, function and metabolism of sialic acids
C. Traving,Roland Schauer +1 more
TL;DR: Sialic acids represent a family of sugar molecules with an unusual and highly variable chemical structure that are found mostly in the terminal position of oligosaccharide chains on the surface of cells and molecules and their metabolism is looked at.