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Essentials of Glycobiology
Ajit Varki,Richard D. Cummings,Jeffrey D. Esko,Hudson H. Freeze,Pamela Stanley,Carolyn R. Bertozzi,Gerald W. Hart,Marilynn E. Etzler +7 more
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TLDR
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function.Abstract:
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function - monosaccharide metabolism N-glycans O-glycans glycosphingolipids glycophospholipid anchors proteoglycans and glycosaminoglycans other classes of golgi-derived glycans nuclear and cytoplasmic glycosylation the O-GlcNAc modification sialic acids structures common to different types of glycans glycosyltransferases degradation and turnover of glycans glycosylation in "model" organisms glycobiology of plant cells bacterial polysaccharides proteins that recognize glycans - discovery and classification of animal lectins P-type lectins I-type lectins C-type lectins selectins S-type lectins (galectins) microbial glycan-binding proteins glycosaminoglycan-binding proteins plant lectins glycans in genetic disorders and disease - genetic disorders of glycosylation in cultured cells naturally occurring genetic disorders of glycosylation in animals determining glycan function using genetically modified mice glycosylation changes in ontogeny and cell activation glycosylation changes in cancer glycobiology of protozoal and helminthic parasites acquired glycosylation changes in human disease methods and applications - structural analysis and sequencing of glycans chemical and enzymatic synthesis of glycans natural and synthetic inhibitors of glycosylation glycobiology in biotechnology and medicine.read more
Citations
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Journal ArticleDOI
The use of mass spectrometry for the proteomic analysis of glycosylation
TL;DR: This review describes methodologies based on MS for detailed characterization of glycoconjugates in complex biological samples at the sensitivity required for proteomic work.
Journal ArticleDOI
Comparative Analysis of Apicomplexa and Genomic Diversity in Eukaryotes
Thomas J. Templeton,Lakshminarayan M. Iyer,Vivek Anantharaman,Shinichiro Enomoto,Juan E. Abrahante,G.M. Subramanian,Stephen L. Hoffman,Mitchell S. Abrahamsen,L. Aravind +8 more
TL;DR: Additional molecular characteristics distinguishing Apicomplexa from other eukaryotes for which complete genome sequences are available are described.
Journal ArticleDOI
A ratiometric lectin microarray approach to analysis of the dynamic mammalian glycome
TL;DR: This work's method for the rapid evaluation of differences in the glycosylation of heterogeneous mammalian samples using a ratiometric two-color lectin microarray approach represents a significant improvement in glycomics technology and sets the stage for the systematic evaluation of how glycans encode biological information in complex systems.
Journal ArticleDOI
Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.
Anne Marie Moody,Daniel Chui,Pedro A. Reche,John J. Priatel,Jamey D. Marth,Ellis L. Reinherz +5 more
TL;DR: Glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8alphabeta coreceptor to the thymocyte surface appear to modulate the ability of the distal binding surface of the dimeric CD8 globular head domains to clamp MHCI.
Journal ArticleDOI
Evidence for Polygenic Adaptation to Pathogens in the Human Genome
Josephine T. Daub,Tamara Hofer,Tamara Hofer,Emilie Cutivet,Isabelle Dupanloup,Isabelle Dupanloup,Lluis Quintana-Murci,Lluis Quintana-Murci,Marc Robinson-Rechavi,Marc Robinson-Rechavi,Laurent Excoffier,Laurent Excoffier +11 more
TL;DR: The results show that past interactions with pathogens have elicited widespread and coordinated genomic responses, and suggest that adaptation to pathogens can be considered as a primary example of polygenic selection.
References
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Book ChapterDOI
Sialic Acids in Molecular and Cellular Interactions
Sørge Kelm,Roland Schauer +1 more
TL;DR: The aim of this chapter is to summarize the knowledge about Sias in masking, for example, galactose residues, and to review the progress made during the past few years with respect to Sias as recognition determinants in the adhesion of pathogenic viruses, bacteria, and protozoa, and particularly as binding sites for endogenous cellular interaction molecules.
Journal ArticleDOI
Structure, function and metabolism of sialic acids
C. Traving,Roland Schauer +1 more
TL;DR: Sialic acids represent a family of sugar molecules with an unusual and highly variable chemical structure that are found mostly in the terminal position of oligosaccharide chains on the surface of cells and molecules and their metabolism is looked at.