Evidence of dysregulation of dendritic cells in primary HIV infection.
Rachel Lubong Sabado,Rachel Lubong Sabado,Meagan O’Brien,Meagan O’Brien,Abhignya Subedi,Abhignya Subedi,Li Qin,Li Qin,Nan Hu,Nan Hu,Elizabeth Taylor,Elizabeth Taylor,Oliver Dibben,Oliver Dibben,Andrea Stacey,Andrea Stacey,Jacques Fellay,Jacques Fellay,Kevin V. Shianna,Kevin V. Shianna,Frederick P. Siegal,Michael Shodell,Kokila Shah,Marie Larsson,Jeffrey D. Lifson,Arthur Nádas,Michael Marmor,Richard Hutt,David M. Margolis,David M. Margolis,Donald Garmon,Donald Garmon,Martin Markowitz,Martin Markowitz,Fred T. Valentine,Persephone Borrow,Persephone Borrow,Nina Bhardwaj,Nina Bhardwaj +38 more
TLDR
It is found that both myeloid DC and plasmacytoid DC levels decline very early during acute HIV infection, which implicates a possible role for DCs in promoting chronic immune activation.About:
This article is published in Blood.The article was published on 2010-11-11 and is currently open access. It has received 173 citations till now. The article focuses on the topics: Dendritic cell & Acquired immune system.read more
Citations
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Journal ArticleDOI
DCs and NK cells: critical effectors in the immune response to HIV-1
TL;DR: Recent insights into how HIV-1 infection affects DC and NK cell function, and the roles of these innate immune cells in HIV- 1 pathogenesis are described.
Journal ArticleDOI
Relative resistance of HIV-1 founder viruses to control by interferon-alpha.
Angharad E. Fenton-May,Oliver Dibben,Tanja Emmerich,Haitao Ding,Katja Pfafferott,Marlén M. I. Aasa-Chapman,Pierre Pellegrino,Ian Williams,Myron S. Cohen,Feng Gao,George M. Shaw,Beatrice H. Hahn,Christina Ochsenbauer,John C. Kappes,John C. Kappes,Persephone Borrow +15 more
TL;DR: The establishment of systemic HIV-1 infection by relatively IFN α-resistant founder viruses lends strong support to the hypothesis that IFNα plays an important role in the control of HIV- 1 replication during the earliest stages of infection, prior to systemic viral spread.
Journal ArticleDOI
Immune activation in the course of HIV‐1 infection: Causes, phenotypes and persistence under therapy
TL;DR: The various causes of immune activation in HIV‐1 infected organisms are discussed: the presence of the virus together with other microbes, eventually coming from the gut, CD4+ T cell lymphopenia, senescence and dysregulation of the immune system, and/or genetic factors.
Journal ArticleDOI
Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α–producing and partially matured phenotype
Meagan O’Brien,Olivier Manches,Rachel Lubong Sabado,Sonia Jimenez Baranda,Yaming Wang,Isabelle Marie,Linda Rolnitzky,Martin Markowitz,David M. Margolis,David E. Levy,Nina Bhardwaj +10 more
TL;DR: It is demonstrated that HIV preferentially traffics to the early endosome in human p DCs and therefore skews pDCs toward a partially matured, persistently IFN-α-secreting phenotype.
Journal ArticleDOI
Dendritic cells in progression and pathology of HIV infection
TL;DR: The multiple roles that dendritic cells play at different stages of HIV infection are discussed, emphasizing their relevance to HIV pathology and progression.
References
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Journal ArticleDOI
Immunobiology of Dendritic Cells
Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
Journal ArticleDOI
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Jason M. Brenchley,David Price,Timothy W. Schacker,Tedi E. Asher,Guido Silvestri,Srinivas S. Rao,Zachary Kazzaz,Ethan Bornstein,Olivier Lambotte,Daniel M. Altmann,Bruce R. Blazar,Benigno Rodriguez,Leia Teixeira-Johnson,Alan L. Landay,Jeffrey N. Martin,Frederick Hecht,Louis J. Picker,Michael M. Lederman,Steven G. Deeks,Daniel C. Douek +19 more
TL;DR: It is shown that increased lipopolysaccharide is bioactive in vivo and correlates with measures of innate and adaptive immune activation, which establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection.
Journal ArticleDOI
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
TL;DR: It is shown that circulating microbial products, probably derived from the gastrointestinal tract, are a cause of HIV-related systemic immune activation and increased lipopolysaccharide is bioactive in vivo and correlates with measures of innate and adaptive immune activation.
Journal ArticleDOI
Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection
Eberhard W. Fiebig,David J. Wright,Bhupat D. Rawal,Patricia E. Garrett,Richard T. Schumacher,Peddada Lorraine B,Charles M. Heldebrant,Richard Smith,Andrew Conrad,Steven Kleinman,Michael P. Busch +10 more
TL;DR: The sequential emergence of assay reactivity allows the classification of primary HIV-1 infection into distinct laboratory stages, which may facilitate the diagnosis of recent infection and stratification of patients enrolled in clinical trials.
Journal ArticleDOI
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction.
Kenya Honda,Yusuke Ohba,Yusuke Ohba,Hideyuki Yanai,Hideo Negishi,Tatsuaki Mizutani,Akinori Takaoka,Choji Taya,Tadatsugu Taniguchi +8 more
TL;DR: Insight is offered into the regulation of TLR9 signalling in space, potentially suggesting a new avenue for therapeutic intervention in response toTLR9 activation.
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