Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses.
Saathvik R. Kannan,Austin N. Spratt,Alisha R. Cohen,S. Hasan Naqvi,Hitendra S. Chand,Thomas P. Quinn,Christian L. Lorson,Siddappa N. Byrareddy,Siddappa N. Byrareddy,Kamal Singh +9 more
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TLDR
In this article, the differences in the mutational profiles of Delta and Delta Plus variants of SARS-CoV-2 have been delineated and structural analysis was conducted to get insights into the impact of mutations on antibody binding.About:
This article is published in Journal of Autoimmunity.The article was published on 2021-08-11 and is currently open access. It has received 175 citations till now. The article focuses on the topics: Delta.read more
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Omicron SARS-CoV-2 variant: Unique features and their impact on pre-existing antibodies
TL;DR: In this article , the authors present the analyses of mutation distribution, the evolutionary relationship of Omicron with previous variants, and probable structural impact of mutations on antibody binding on SARS-CoV-2.
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Mitigating Covid-19 in the face of emerging virus variants, breakthrough infections and vaccine hesitancy
Azizul Haque,Anudeep B. Pant +1 more
TL;DR: In this paper , the authors consider the conditions that may facilitate viral mutations and the emergence of variants with the ability to evade immunity and discuss the importance of vaccination with the currently available vaccines.
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Impaired detection of omicron by SARS-CoV-2 rapid antigen tests
Andreas Osterman,Irina Badell,Elif Basara,Marcel Stern,Fabian Kriesel,Marwa Eletreby,Gamze Naz Öztan,Melanie Huber,Hanna Autenrieth,Ricarda Knabe,P Späth,Maximilian Muenchhoff,Alexander Graf,Stefan Krebs,Helmut Blum,Jürgen Durner,Ludwig Czibere,Christopher Dächert,Lars Kaderali,Hanna-Mari Baldauf,Oliver T. Keppler +20 more
TL;DR: In this paper , the authors evaluated the performance of nine SARS-CoV-2 RATs in a single-centre laboratory study and found that up to 10-fold or 101-fold higher virus loads were required for omicron- compared to delta-containing samples.
Journal ArticleDOI
New Coronavirus Variants are Creating More Challenges to Global Healthcare System: A Brief Report on the Current Knowledge
TL;DR: The Delta and Omicron variants are more highly transmissible than Alpha, Beta, and Gamma variants as discussed by the authors , and the transmissibility and resistance of the recently identified OmicRON variant is still unclear.
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Is the SARS CoV-2 Omicron Variant Deadlier and More Transmissible Than Delta Variant?
Bao V. Duong,Puchanee Larpruenrudee,Tian Fang,Sheikh I. Hossain,Suvash C. Saha,Y. Gu,Mohammad S. Islam +6 more
TL;DR: Australia and the five most affected countries are selected in order to review the transmissibility, severity and fatality due to Delta and Omicron variants, and the vaccination programs for each country are reviewed as the main factor in prevention.
References
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The Protein Data Bank
Helen M. Berman,John D. Westbrook,Zukang Feng,Gary L. Gilliland,Talapady N. Bhat,Helge Weissig,Ilya N. Shindyalov,Philip E. Bourne +7 more
TL;DR: The goals of the PDB are described, the systems in place for data deposition and access, how to obtain further information and plans for the future development of the resource are described.
Journal ArticleDOI
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
Journal ArticleDOI
Nextstrain: real-time tracking of pathogen evolution.
James Hadfield,Colin Megill,Sidney M Bell,Sidney M Bell,John Huddleston,John Huddleston,Barney Potter,Charlton Callender,Pavel Sagulenko,Trevor Bedford,Richard A. Neher,Richard A. Neher,Richard A. Neher +12 more
TL;DR: Nextstrain consists of a database of viral genomes, a bioinformatics pipeline for phylodynamics analysis, and an interactive visualization platform that presents a real-time view into the evolution and spread of a range of viral pathogens of high public health importance.
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Data, disease and diplomacy: GISAID's innovative contribution to global health
TL;DR: The article finds that the Global Initiative on Sharing All Influenza Data contributes to global health in at least five ways: collating the most complete repository of high‐quality influenza data in the world; facilitating the rapid sharing of potentially pandemic virus information during recent outbreaks; supporting the World Health Organization's biannual seasonal flu vaccine strain selection process; developing informal mechanisms for conflict resolution around the sharing of virus data.
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RNA virus mutations and fitness for survival
Esteban Domingo,John J. Holland +1 more
TL;DR: E Epidemiological as well as functional and structural studies suggest that RNA viruses can tolerate restricted types and numbers of mutations during any specific time point during their evolution, which may open new avenues for combating viral infections.
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