Evolutionary medicine and bone loss in chronic inflammatory diseases--A theory of inflammation-related osteopenia.
TLDR
It is worked out that bone waste is an adaptive, evolutionarily positively selected program that is absolutely necessary during acute inflammation, but when acute inflammation enters a chronic state due to the inability to terminate inflammation, the acute program of bone loss is a misguided adaptive program.About:
This article is published in Seminars in Arthritis and Rheumatism.The article was published on 2015-10-01 and is currently open access. It has received 75 citations till now. The article focuses on the topics: Inflammation & Ankylosing spondylitis.read more
Citations
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Chronic inflammation in the etiology of disease across the life span
David Furman,Judith Campisi,Judith Campisi,Eric Verdin,Pedro Carrera-Bastos,Sasha Targ,Claudio Franceschi,Luigi Ferrucci,Derek W. Gilroy,Alessio Fasano,Gary W. Miller,Andrew H. Miller,Alberto Mantovani,Alberto Mantovani,Alberto Mantovani,Cornelia M. Weyand,Nir Barzilai,Jorge Goronzy,Thomas A. Rando,Thomas A. Rando,Rita B. Effros,Alejandro Lucia,Nicole Kleinstreuer,George M. Slavich +23 more
TL;DR: The multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress are described.
Journal ArticleDOI
The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates.
Claudio Franceschi,Paolo Garagnani,Cristina Morsiani,Maria Conte,Aurelia Santoro,Andrea Grignolio,Daniela Monti,Miriam Capri,Stefano Salvioli +8 more
TL;DR: The hypothesis that ARDs and GSs such as frailty can be conceptualized as accelerated aging will be discussed, and the use of DNA methylation, N-glycans profiling, and gut microbiota composition to complement the available disease-specific markers are proposed.
Journal ArticleDOI
Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early) : a multicentre, randomised, double-blind, double-dummy, strategy trial
Johannes W. J. Bijlsma,Paco M J Welsing,Thasia G. Woodworth,Leonie M Middelink,Attila Pethö-Schramm,Corrado Bernasconi,Michelle E A Borm,Cornelis H Wortel,Evert Jan ter Borg,Z. Nazira Jahangier,Willemijn H van der Laan,George A W Bruyn,Paul Baudoin,Siska Wijngaarden,Petra Vos,R. Bos,Mirian Starmans,E. N. Griep,Joanna R M Griep-Wentink,Cornelia F Allaart,A H M Heurkens,Xavier M Teitsma,Janneke Tekstra,Anne C. A. Marijnissen,Floris P J G Lafeber,Johannes W G Jacobs +25 more
TL;DR: The proportion of patients achieving sustained remission (defined as DAS28 <2·6 with a swollen joint count ≤four, persisting for at least 24 weeks) on the initial regimen and during the entire study duration was compared between groups with a two-sided Cochran-Mantel-Haenszel test.
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The gut-bone axis: how bacterial metabolites bridge the distance
TL;DR: This Review will focus on the effects ofSCFAs on the musculoskeletal system and discuss the mechanisms whereby SCFAs regulate bone cells.
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Chronic inflammatory systemic diseases An evolutionary trade-off between acutely beneficial but chronically harmful programs
TL;DR: Considering evolved energy trade-offs helps to understand how an energy imbalance can lead to the disease sequelae of CIDs and clinicians must translate this knowledge into early diagnosis and symptomatic treatment in CIDs.
References
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2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.
Daniel Aletaha,Tuhina Neogi,Alan J. Silman,Julia Funovits,David T. Felson,Clifton O. Bingham,Neal S. Birnbaum,Gerd Burmester,Vivian P. Bykerk,Marc D. Cohen,Bernard Combe,Karen H. Costenbader,Maxime Dougados,Paul Emery,Gianfranco Ferraccioli,Johanna M. W. Hazes,Kathryn Hobbs,Tom W J Huizinga,Arthur Kavanaugh,Jonathan Kay,Tore K Kvien,Timothy J. Laing,Philip J. Mease,Henri A Ménard,Larry W. Moreland,Raymond L. Naden,Theodore Pincus,Josef S Smolen,Ewa Stanislawska-Biernat,Deborah P M Symmons,Paul P. Tak,Katherine S. Upchurch,Jiří Vencovský,Frederick Wolfe,Gillian A. Hawker +34 more
TL;DR: This new classification system redefines the current paradigm of RA by focusing on features at earlier stages of disease that are associated with persistent and/or erosive disease, rather than defining the disease by its late-stage features.
Journal ArticleDOI
2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.
Daniel Aletaha,Tuhina Neogi,Alan J. Silman,Julia Funovits,David T. Felson,Clifton O. Bingham,Neal S. Birnbaum,Gerd Burmester,Vivian P. Bykerk,Marc D. Cohen,Bernard Combe,Karen H. Costenbader,Maxime Dougados,Paul Emery,Gianfranco Ferraccioli,Johanna M. W. Hazes,Kathryn Hobbs,Tom W J Huizinga,Arthur Kavanaugh,Jonathan Kay,Tore K Kvien,Timothy J. Laing,Philip J. Mease,Henri A Ménard,Larry W. Moreland,Raymond L. Naden,Theodore Pincus,Josef S Smolen,Ewa Stanislawska-Biernat,Deborah P M Symmons,Paul P. Tak,Katherine S. Upchurch,Jiří Vencovský,Frederick Wolfe,Gillian A. Hawker +34 more
TL;DR: This new classification system redefines the current paradigm of RA by focusing on features at earlier stages of disease that are associated with persistent and/or erosive disease, rather than defining the disease by its late-stage features.
Journal ArticleDOI
From inflammation to sickness and depression: when the immune system subjugates the brain
TL;DR: In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour, which can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals.
Journal ArticleDOI
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
Claudio Franceschi,Massimiliano Bonafè,Silvana Valensin,Fabiola Olivieri,Maria De Luca,Enzo Ottaviani,Giovanna De Benedictis +6 more
TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
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Immune-neuro-endocrine interactions: facts and hypotheses.
Hugo O. Besedovsky,A del Rey +1 more
TL;DR: At the beginning of the second half of the 20th century, most efforts were directed at understanding the molecular and cellular basis of the immune response and the mechanisms of acquisition of immunologic responses.