Journal ArticleDOI
Evolving concepts in the treatment of relapsing multiple sclerosis.
TLDR
Before starting a treatment, neurologists should carefully consider the state of the disease, its prognostic factors and comorbidities, the patient's response to previous treatments, and whether the patient is likely to accept treatment-related risks in order to maximise benefits and minimise risks.About:
This article is published in The Lancet.The article was published on 2017-04-01. It has received 234 citations till now.read more
Citations
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Journal ArticleDOI
The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017.
Günther Deuschl,Günther Deuschl,Ettore Beghi,Ettore Beghi,Franz Fazekas,Franz Fazekas,Timea Varga,Kalliopi A Christoforidi,Eveline Sipido,Claudio L. Bassetti,Claudio L. Bassetti,Theo Vos,Theo Vos,Valery L. Feigin,Valery L. Feigin +14 more
TL;DR: The burden of neurological disorders in Europe was higher in men than in women, peaked in individuals aged 80-84 years, and varied substantially with WHO European region and country.
Journal ArticleDOI
Treatment of multiple sclerosis — success from bench to bedside
TL;DR: The modern era of multiple sclerosis therapy reached primary progressive MS in 2018, with the approval of ocrelizumab, and major developments are charted and discussed to discuss the implications for current and future patient management.
Journal ArticleDOI
Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis
Paolo A. Muraro,Roland Martin,Giovanni Luigi Mancardi,Richard Nicholas,Maria Pia Sormani,Riccardo Saccardi +5 more
TL;DR: Evidence indicates that the patients who are most likely to benefit from and tolerate AHSCT are young, ambulatory and have inflammatory MS activity, and clinical trials are required to rigorously test the efficacy, safety and cost-effectiveness of A HSCT against highly active MS drugs.
Journal ArticleDOI
Multiple sclerosis and cognition: synaptic failure and network dysfunction
TL;DR: The hypothesis that, during MS, immune-mediated alterations of synapses’ ability to express long-term plastic changes may contribute to the pathogenesis of cognitive impairment by interfering with the dynamics of neuronal networks is discussed.
Journal ArticleDOI
Reaching an evidence-based prognosis for personalized treatment of multiple sclerosis.
Dalia Rotstein,Xavier Montalban +1 more
TL;DR: The factors that need to be taken into account to make personalized treatment decisions are discussed, including comorbidities, pregnancy planning, patient preferences, risk tolerance, safety, cost and treatment sequencing should be considered in addition to prognosis.
References
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Journal ArticleDOI
Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Journal ArticleDOI
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
Chris H. Polman,Eva Havrdova,Michael Hutchinson,Ludwig Kappos,David Miller,J. Theodore Phillips,Fred D. Lublin,Gavin Giovannoni,A Wajgt,Martin Toal,F Lynn,Michael Panzara,Alfred Sandrock +12 more
TL;DR: Natalizumab reduced the risk of the sustained progression of disability and the rate of clinical relapse in patients with relapsing multiple sclerosis and hold promise as an effective treatment for relapsed multiple sclerosis.
Journal ArticleDOI
Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
Lawrence Jacobs,Diane Cookfair,Richard A. Rudick,Robert M. Herndon,John R. Richert,Andres M. Salazar,J. S. Fischer,Donald E. Goodkin,Carl V. Granger,Jack H. Simon,John J. Alam,David M. Bartoszak,Dennis Bourdette,Jonathan Braiman,Carol M. Brownscheidle,Michael E. Coats,Stanley Cohan,David S. Dougherty,R. P. Kinkel,Michele Mass,Frederick Munschauer,Roger L. Priore,Patrick M. Pullicino,Barbara J. Scherokman,Bianca Weinstock-Guttman,Ruth H. Whitham +25 more
TL;DR: Interferon beta‐ la had a significant beneficial impact in relapsing multiple sclerosis patients by reducing the accumulation of permanent physical disability, exacerbation frequency, and disease activity measured by gadolinium‐enhanced lesions on brain magnetic resonance images.
Journal ArticleDOI
A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
Ludwig Kappos,Ernst Wilhelm Radue,Paul O'Connor,Chris H. Polman,Reinhard Hohlfeld,Peter A. Calabresi,Krzysztof Selmaj,Catherine Agoropoulou,Malgorzata Leyk,Lixin Zhang-Auberson,Pascale Burtin +10 more
TL;DR: Both doses of oral fingolimod improved the relapse rate, the risk of disability progression, and end points on MRI and were superior to placebo with regard to MRI-related measures.
Journal ArticleDOI
Defining the clinical course of multiple sclerosis: The 2013 revisions
Fred D. Lublin,Stephen C. Reingold,Jeffrey A. Cohen,Gary Cutter,Per Soelberg Sørensen,Alan J. Thompson,Jerry S. Wolinsky,Laura J. Balcer,Brenda Banwell,Frederik Barkhof,Bruce F. Bebo,Peter A. Calabresi,Michel Clanet,Giancarlo Comi,Robert J. Fox,Mark S. Freedman,Andrew D. Goodman,Matilde Inglese,Ludwig Kappos,Bernd C. Kieseier,John A. Lincoln,Catherine Lubetzki,Aaron E. Miller,Xavier Montalban,Paul O'Connor,John Petkau,Carlo Pozzilli,Richard A. Rudick,Maria Pia Sormani,Olaf Stüve,Emmanuelle Waubant,Chris H. Polman +31 more
TL;DR: Refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression are proposed and strategies for future research to better define phenotypes are outlined.
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