Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics
Juliane C. Campos,Luiz Henrique Marchesi Bozi,Barbara Krum,Luiz Roberto Grassmann Bechara,Nikolas D. Ferreira,Gabriel S. Arini,Rudá Prestes e Albuquerque,Annika Traa,Takafumi Ogawa,Alexander M. van der Bliek,Afshin Beheshti,Edward T. Chouchani,Jeremy M. Van Raamsdonk,T. Keith Blackwell,Julio C.B. Ferreira +14 more
Reads0
Chats0
TLDR
In this article , the role of dynamic mitochondrial remodeling in exercise was investigated using Caenorhabditis elegans, and it was found that the dynamic cycle of mitochondrial fission-fusion is critical for physical fitness.Abstract:
Significance Exercise is a powerful anti-aging intervention. In muscle, exercise remodels mitochondrial metabolism and connectiveness, but the role of dynamic mitochondrial remodeling in exercise remains unknown. Using Caenorhabditis elegans, we find that the dynamic cycle of mitochondrial fission–fusion is critical for physical fitness. Exercise induces remodeling of the proteome that depends upon mitochondrial dynamics and delays an aging-associated decline in mitochondrial connectiveness and physical fitness. AMPK, a metabolic regulator that senses low energy availability and controls mitochondrial dynamics, is needed for exercise to maintain physical fitness with age and can recapitulate this exercise benefit. Our data identify the mitochondrial dynamics cycle as an essential mediator of exercise responsiveness and an entry point for interventions to maintain muscle function during aging.read more
Citations
More filters
Journal ArticleDOI
Mitochondrial dysfunction in aging
Jiming Kong,Mark Zeitoun +1 more
TL;DR: In this paper , a review summarizes mechanisms essential for maintaining mitochondrial homeostasis and emphasizes that imbalanced MQC may accelerate cellular senescence and aging, and suggests that appropriate interventions on MQCs may delay the aging process and extend lifespan.
Journal ArticleDOI
Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity
Anne Gemmink,Sabine Daemen,Jakob Wefers,Jan Hansen,Dirk van Moorsel,Puji Astuti,Johanna Jorgensen,Esther Kornips,Gert Schaart,Joris Hoeks,Patrick Schrauwen,Matthijs K. C. Hesselink +11 more
TL;DR: In this paper , the authors visualized and quantified the mitochondrial network morphology in human skeletal muscle of young healthy lean and older individuals with obesity over the course of 24 hours, with a more fused network coinciding with higher mitochondrial respiratory capacity.
Journal ArticleDOI
A worm’s life: AMPK links muscle mitochondrial dynamics to physical fitness and healthy aging in Caenorhabditis elegans
TL;DR: In this article , a balance between fusion and fission was found to be critical for healthy aging and energy efficiency, as well as for delaying cardiovascular and metabolic diseases in skeletal muscle.
Journal ArticleDOI
Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies
TL;DR: In this article , the authors explore the physiological and pathological roles of mitochondrial fission, its regulation by dynamin-related protein 1 (Drp1), and the interplay between reactive oxygen species (ROS) and mitochondria in health and metabolic diseases.
References
More filters
Journal ArticleDOI
The Hallmarks of Aging
TL;DR: Nine tentative hallmarks that represent common denominators of aging in different organisms are enumerated, with special emphasis on mammalian aging, to identify pharmaceutical targets to improve human health during aging, with minimal side effects.
Journal ArticleDOI
Gait speed and survival in older adults.
Stephanie A. Studenski,Subashan Perera,Kushang V. Patel,Caterina Rosano,Kimberly A. Faulkner,Marco Inzitari,Jennifer S. Brach,Julie Chandler,Peggy M. Cawthon,Elizabeth Connor,Michael C. Nevitt,Marjolein Visser,Stephen B. Kritchevsky,Stefania Badinelli,Tamara B. Harris,Anne B. Newman,Jane A. Cauley,Luigi Ferrucci,Jack M. Guralnik +18 more
TL;DR: In this pooled analysis of individual data from 9 selected cohorts, gait speed was associated with survival in older adults and predicted survival was as accurate as predicted based on age, sex, use of mobility aids, and self-reported function.
Journal ArticleDOI
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig,Alvaro A. Elorza,Anthony J.A. Molina,Anthony J.A. Molina,Hibo Mohamed,Jakob D. Wikstrom,Gil Walzer,Linsey Stiles,Sarah E. Haigh,Steve Katz,Guy Las,Joseph Alroy,Min Wu,Bénédicte F. Py,Junying Yuan,Jude T. Deeney,Barbara E. Corkey,Orian S. Shirihai +17 more
TL;DR: Pulse chase and arrest of autophagy at the pre‐proteolysis stage reveal that fission followed by selective fusion segregates dysfunctional mitochondria and permits their removal by autophagic.
Journal ArticleDOI
The genetics of ageing
TL;DR: The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live for 100 years or more, which means that over evolutionary time mutations have increased lifespan more than 2,000-fold.
Journal ArticleDOI
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
TL;DR: The data indicate that AMPK phosphorylation of PGC-1α initiates many of the important gene regulatory functions of AMPK in skeletal muscle.