Expression of brain natriuretic peptide gene in human heart. Production in the ventricle.
Kiminori Hosoda,Kazuwa Nakao,Masashi Mukoyama,Yoshihiko Saito,Michihisa Jougasaki,Gotaro Shirakami,Shin Ichi Suga,Yoshihiro Ogawa,Hirofumi Yasue,Hiroo Imura +9 more
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TLDR
It is demonstrated that the ventricle is a major production site of brain natriuretic peptide, in contrast with atrial natriuric peptide mRNA, which is present mainly in the atrium.Abstract:
To elucidate the expression of the brain natriuretic peptide gene in the human heart, we have measured brain natriuretic peptide mRNA levels in hearts using the Northern blot hybridization method. Brain natriuretic peptide mRNA was present with a size of approximately 0.9 kb in the ventricle as well as in the atrium. The brain natriuretic peptide mRNA level in the ventricle was 52% of that in the atrium, whereas the atrial natriuretic peptide mRNA level in the ventricle was approximately two orders of magnitude lower than that in the atrium. Taking atrial and ventricular weights into account, the total amount of brain natriuretic peptide mRNA in the ventricle represented 77% of that in the whole heart. These results demonstrate that most of brain natriuretic peptide mRNA occurs in the ventricle, in contrast with atrial natriuretic peptide mRNA, which is present mainly in the atrium, indicating that the ventricle is a major production site of brain natriuretic peptide.read more
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B-type natriuretic peptide in cardiovascular disease
TL;DR: Measurement of circulating concentrations of B-type natriuretic peptide and the N-terminal fragment of its prohormones and use of recombinant human BNP (nesiritide) and vasopeptidase inhibitors to treat heart failure are focused on.
Journal ArticleDOI
Plasma Brain Natriuretic Peptide as an Indicator of Left Ventricular Systolic Function and Long-term Survival After Acute Myocardial Infarction Comparison With Plasma Atrial Natriuretic Peptide and N-Terminal Proatrial Natriuretic Peptide
Torbjørn Omland,A. Aakvaag,Vernon V. S. Bonarjee,Kenneth Caidahl,Rolv Terje Lie,Dennis W.T. Nilsen,Johan Sundsfjord,Kenneth Dickstein +7 more
TL;DR: Although plasma ANP appears to be a better predictor of left ventricular dysfunction, plasma BNP may have greater potential to complement standard prognostic indicators used in risk stratification after AMI because of its strong, independent association with long-term survival, enhanced in vitro stability, and simplicity of analysis.
Journal ArticleDOI
Plasma Brain Natriuretic Peptide-Guided Therapy to Improve Outcome in Heart Failure: The STARS-BNP Multicenter Study
Patrick Jourdain,Guillaume Jondeau,François Funck,Pascal Gueffet,Alain Le Helloco,Erwan Donal,Jean François Aupetit,Marie Claude Aumont,Michel Galinier,Jean Christophe Eicher,Alain Cohen-Solal,Yves Juillière +11 more
TL;DR: In optimally treated CHF patients, a BNP-guided strategy reduced the risk of CHF-related death or hospital stay for CHF, mainly through an increase in ACEI and beta-blocker dosages.
Journal ArticleDOI
Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure.
Michihiro Yoshimura,Hirofumi Yasue,Ken Okumura,Hisao Ogawa,Michihisa Jougasaki,Masashi Mukoyama,Kazuwa Nakao,Hiroo Imura +7 more
TL;DR: It is concluded that plasma levels of BNP mainly reflect the degree of ventricular overload and that the secretion patterns of ANP and BNP vary with underlying cardiac disorders of CHF with different degrees of overload in atria and ventricles.
Journal ArticleDOI
Plasma Brain Natriuretic Peptide Levels Increase in Proportion to the Extent of Right Ventricular Dysfunction in Pulmonary Hypertension
Noritoshi Nagaya,Toshio Nishikimi,Yoshiaki Okano,Masaaki Uematsu,Toru Satoh,Shingo Kyotani,Sachio Kuribayashi,Seiki Hamada,Mikio Kakishita,Norifumi Nakanishi,Makoto Takamiya,Takeyoshi Kunieda,Hisayuki Matsuo,Kenji Kangawa +13 more
TL;DR: Plasma BNP increases in proportion to the extent of RV dysfunction in pulmonary hypertension, and the BNP/ANP ratio was significantly higher in patients with RVPO than with RVVO.
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A new natriuretic peptide in porcine brain
TL;DR: The brain natriuretic peptide (BNP) as mentioned in this paper was identified in porcine brain of a novel peptide of 26 amino acid residues, eliciting a pharmacological spectrum very similar to that of ANP.
Journal ArticleDOI
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Journal ArticleDOI
Brain natriuretic peptide is a novel cardiac hormone
Yoshihiko Saito,Kazuwa Nakao,Hiroshi Itoh,Takayuki Yamada,Masashi Mukoyama,Hiroshi Arai,Kiminori Hosoda,Gotaro Shirakami,Shin Ichi Suga,Naoto Minamino,Kenji Kangawa,Hisayuki Matsuo,Hiroo Imura +12 more
TL;DR: Results indicate that BNP is synthesized in and is secreted into the circulation from the heat in a similar fashion as ANP.
Journal ArticleDOI
Cloning and sequence analysis of cDNA encoding a precursor for porcine brain natriuretic peptide
Keiji Maekawa,Tetsuji Sudoh,Mitsuru Furusawa,Naoto Minamino,Kenji Kangawa,Hiroaki Ohkubo,Shigetada Nakanishi,Hisayuki Matsuo +7 more
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