Journal ArticleDOI
Facile, efficient approach to accomplish tunable chemistries and variable biodistributions for shell cross-linked nanoparticles.
Guorong Sun,Aviv Hagooly,Jinqi Xu,Andreas M. Nyström,Zicheng Li,Raffaella Rossin,Dennis A. Moore,Karen L. Wooley,Michael J. Welch +8 more
TLDR
The in vivo behavior of shell cross-linked knedel-like (SCK) nanoparticles is shown to be tunable via a straightforward and versatile process that advances SCKs as attractive nanoscale carriers in the field of nanomedics.About:
This article is published in Biomacromolecules.The article was published on 2008-05-30. It has received 94 citations till now. The article focuses on the topics: Nanomedicine.read more
Citations
More filters
Journal ArticleDOI
Design of polymeric nanoparticles for biomedical delivery applications
TL;DR: This tutorial review highlights the importance of well-defined chemistries, with detailed ties to specific biological hurdles and opportunities, in the design of nanostructures for various biomedical delivery applications.
Journal ArticleDOI
Multimodality Imaging Probes: Design and Challenges
TL;DR: This review provides an overview of the many strategies that have been applied to achieve multimodal functionality in a single probe unit and the caveat is that because the sensitivities of different imaging modalities can vary by 3 orders of magnitude, it may not be practical to simply add all functionalities to one molecule.
Journal ArticleDOI
Methods for the preparation and manufacture of polymeric nanoparticles.
TL;DR: This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules and presents the most recent innovations and progresses obtained over the last decade.
Journal ArticleDOI
Polymeric Nanostructures for Imaging and Therapy.
TL;DR: High efficiency in diagnosis and treatment of diseases and improving patient quality of life and compliance can be achieved through understanding the molecular events associated with various diseases, and combining the advances in the design of therapeutic and diagnostic agents and nanomaterials, together with the innovative instruments utilized for monitoring these agents.
Journal ArticleDOI
Copper-64 Radiopharmaceuticals for PET Imaging of Cancer: Advances in Preclinical and Clinical Research
TL;DR: CoCopper-64 (T1/2) = 12.7 hours; β+, 0.653 MeV [17.8 %]; β−, 0.579 MEV [38.4 %]) has decay characteristics that allow for positron emission tomography (PET) imaging and targeted radiotherapy of cancer as discussed by the authors.
References
More filters
Journal ArticleDOI
Self-assembled monolayers of thiolates on metals as a form of nanotechnology.
Journal ArticleDOI
Cancer nanotechnology: opportunities and challenges.
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.