Journal ArticleDOI
Factors affecting lipase digestibility of emulsified lipids using an in vitro digestion model: Proposal for a standardised pH-stat method
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In this article, the authors focus on the impact of various experimental factors on lipid digestion in oil-in-water emulsions, using a pH-stat method that simulates the small intestine.About:
This article is published in Food Chemistry.The article was published on 2011-05-15. It has received 295 citations till now. The article focuses on the topics: Lipid digestion & Lipase.read more
Citations
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Influence of particle size on lipid digestion and β-carotene bioaccessibility in emulsions and nanoemulsions
TL;DR: In this article, the influence of particle size on lipid digestion and β-carotene bioaccessibility using corn oil-in-water emulsions with different initial droplet diameters.
Journal ArticleDOI
Review of in vitro digestion models for rapid screening of emulsion-based systems
David Julian McClements,Yan Li +1 more
TL;DR: The current status of in vitro digestion models for simulating lipid digestion, with special emphasis on the pH stat method, are reviewed, to test the efficacy of different approaches of controlling lipid digestion under conditions that simulate the human gastrointestinal tract.
Journal ArticleDOI
Potential biological fate of ingested nanoemulsions: influence of particle characteristics.
TL;DR: A brief review of the current status of the formation, properties, and potential biological fate of food-grade nanoemulsions focuses on the influence of particle characteristics, such as size and interfacial properties, on the digestion and absorption of lipid nanoparticles.
Journal ArticleDOI
Development and evaluation of lipid nanocarriers for quercetin delivery: A comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE)
N.P. Aditya,Ana Sofia Macedo,Slavomira Doktorovova,Eliana B. Souto,Eliana B. Souto,Saehoon Kim,Pahn-Shick Chang,Sanghoon Ko +7 more
TL;DR: This study showed that by optimally controlling the lipid physical state and composition, it is possible to fabricate the lipid nanocarriers with desired properties.
Journal ArticleDOI
The physicochemical stability and in vitro bioaccessibility of beta-carotene in oil-in-water sodium caseinate emulsions
TL;DR: In this article, the Beta-carotene (BC) was homogenized with 2% sodium caseinate solution in a microfluidizer, which produced droplet diameters that were linear and inversely related to homogenization pressures in the pressure range 10-100MPa.
References
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Book
Food Emulsions: Principles, Practice, and Techniques
TL;DR: In this paper, the authors present an analysis of food emulsion properties using computer modeling of liquid properties and measurements of molecular characteristics, such as colloidal interactions and droplet aggregation, in order to predict colloidal interaction in food emulsions.
Journal ArticleDOI
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
TL;DR: The mechanisms by which lipids and lipidic excipients affect the oral absorption of lipophilic drugs are detailed and a perspective on the possible future applications of lipid-based delivery systems is provided.
Journal ArticleDOI
Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system ☆
Formulation of poorly water-soluble drugs for oral administration
TL;DR: The use of a lipid formulation classification system combined with appropriate in vitro tests will help to establish a database for in vitro-in vivo correlation studies and improve the understanding of the factors which affect drug crystallization.
Journal ArticleDOI
Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies.
TL;DR: The properties of excipients are discussed, the formulation strategies that can be used for each type of lipid formulation are outlined, and a framework for the in vitro testing of each type is suggested.
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