Journal ArticleDOI
Fluoride Interactions: From Molecules to Disease
TLDR
Fluoride has long been known to influence the activity of various enzymes in vitro as mentioned in this paper, with far-reaching consequences for our understanding of fundamental biological processes, and it has been demonstrated that many effects primarily attributed to fluoride are caused by synergistic action of fluoride plus aluminum.Abstract:
Fluoride has long been known to influence the activity of various enzymes in vitro. Later it has been demonstrated that many effects primarily attributed to fluoride are caused by synergistic action of fluoride plus aluminum. Aluminofluoride complexes have been widely used as analogues of phosphate groups to study phosphoryl transfer reactions and heterotrimeric G proteins involvement. A num- ber of reports on their use have appeared, with far-reaching consequences for our understanding of fundamental biological processes. Fluoride plus aluminum send false messages, which are amplified by processes of signal transduction. Many investigations of the long- term administration of fluoride to laboratory animals have demonstrated that fluoride and aluminofluoride complexes can elicit impair- ment of homeostasis, growth, development, cognition, and behavior. Ameliorative effects of calcium, vitamins C, D, and E have been re- ported. Numerous epidemiological, ecological, and clinical studies have shown the effects of fluoride on humans. Millions of people live in endemic fluorosis areas. A review of fluoride interactions from molecules to disease is necessary for a sound scientific assessment of health risks, which may be linked to the chronic intake of small doses of fluoride and aluminum from environmental and artificial sources.read more
Citations
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Journal ArticleDOI
Aluminum and Alzheimer's Disease: After a Century of Controversy, Is there a Plausible Link?
TL;DR: The hypothesis that Al significantly contributes to AD is built upon very solid experimental evidence and should not be dismissed, and immediate steps should be taken to lessen human exposure to Al, which may be the single most aggravating and avoidable factor related to AD.
Journal ArticleDOI
Chemical Aspects of Human and Environmental Overload with Fluorine
Jianlin Han,Loránd Kiss,Haibo Mei,Attila Márió Remete,Maja Ponikvar-Svet,Daniel M. Sedgwick,Raquel Román,Santos Fustero,Hiroki Moriwaki,Vadim A. Soloshonok,Vadim A. Soloshonok +10 more
TL;DR: A comprehensive and critical review of the effects of fluoride ions and organofluorine compounds (mainly pharmaceuticals and agrochemicals) on human health and the environment is presented in this article.
Journal ArticleDOI
Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders
TL;DR: It is suggested that environmental and dietary excitotoxins, mercury, fluoride, and aluminum can exacerbate the pathological and clinical problems by worsening excitOToxicity and by microglial priming.
Journal ArticleDOI
Fluoride and human health: Systematic appraisal of sources, exposures, metabolism, and toxicity
TL;DR: The present study reviews the mechanisms of F− ingestion from possible sources and exposures, correlating possible health effects by extensively surveying the literature and describes extensive in vivo or in vitro studies of F − ingestion in laboratory animals and the correlation ofF− exposure with several health effects.
Journal ArticleDOI
Proteomic analysis of gastrocnemius muscle in rats with streptozotocin-induced diabetes and chronically exposed to fluoride.
Aline de Lima Leite,Janete Gualiume Vaz Madureira Lobo,Heloísa Aparecida Barbosa da Silva Pereira,Mileni da Silva Fernandes,Tatiani Martini,Fernanda Zucki,Doris Hissako Sumida,Alfredo Rigalli,Marília Afonso Rabelo Buzalaf +8 more
TL;DR: The profile of protein expression in the gastrocnemius muscle of rats with streptozotocin-induced diabetes that were chronically exposed to F indicates an increase in IR, which might worsen diabetes.
References
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