Journal ArticleDOI
Friend virus-induced erythroleukemia and the multistage nature of cancer.
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This article is published in Cell.The article was published on 1991-09-06. It has received 241 citations till now. The article focuses on the topics: Friend leukemia & Friend virus.read more
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Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
Olivier Delattre,Jessica Zucman,Béatrice Plougastel,Chantal Desmaze,Thomas Melot,Martine Peter,Heinrich Kovar,Isabelle Joubert,Pieter J. de Jong,Guy A. Rouleau,Alain Aurias,Gilles Thomas +11 more
TL;DR: Phylogenetically conserved restriction fragments in the vicinity of EWSR1 and EWSR2, the genomic regions where the breakpoints of chromosome 22 and chromosome 11 are, respectively, have allowed identification of transcribed sequences from these regions and has indicated that a hybrid transcript might be generated by the translocation.
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p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage
Kay F. Macleod,Nicole Sherry,Greg Hannon,David Beach,Takashi Tokino,Kenneth Kinzler,Bert Vogelstein,Tyler Jacks +7 more
TL;DR: It is shown that normal tissue expression of p21 to high levels is not dependent on p53 and confirm that induction of p23 by DNA-damaging agents does require p53, and p53 appears to play a critical role in p21 induction following DNA damage.
Journal ArticleDOI
Abnormal Centrosome Amplification in the Absence of p53
TL;DR: In mouse embryonic fibroblasts lacking the p53 tumor suppressor protein, multiple copies of functionally competent centrosomes are generated during a single cell cycle, implicate p53 in the regulation of centrosome duplication and suggest one possible mechanism by which the loss of p53 may cause genetic instability.
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A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins.
I J Miller,James J. Bieker +1 more
TL;DR: The tissue expression pattern of EKLF, in conjunction with its function as a transcriptional activator, strongly suggests that the EKlF protein may be intimately involved in establishment and/or maintenance of the erythroid cell phenotype.
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Acute myeloid leukemia: epidemiology and etiology.
Barbara Deschler,Michael Lübbert +1 more
TL;DR: To estimate outcome and discuss informed treatment decisions with AML patients of different age groups and different biologic risk categories, it is mandatory to consider that the outcome results reported in clinical trials were until now heavily biased toward younger patients, whereas the overall dismal prognosis documented in population‐based studies most likely reflects the exclusion of older patients from aggressive treatment.
References
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The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene.
TL;DR: A cDNA clone that codes for a new tissue-specific DNA binding protein, PU.1, was isolated and was shown to be a transcriptional activator that is expressed in macrophages and B cells.
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Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia.
TL;DR: A disease with the characteristics of a leukemia has been found to be serially transmissible in adult Swiss mice by means of cell-free filtrates and intraperitoneal, subcutaneous, intracerebral, and intramuscular injections are all effective.
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Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation
TL;DR: The results indicate that the p53-encoding gene can play a causal role in the conversion of normal fibroblasts into tumorigenic cells, suggesting an important role of p53 in tumorigenesis.
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Spi-1 is a putative oncogene in virally induced murine erythroleukaemias
TL;DR: The characterization of a new putative oncogene isolated from a murine erythroleukaemia induced by the acute leukaemogenic retrovirus spleen focus forming virus (SFFV) is reported, with an important and unusual feature of this genomic locus Spi-l (for SFFV proviral integration) is that rearrangements due to S FFV integration were found in 95% of the erythyroid tumours studied.