Journal ArticleDOI
Function and Evolution of Upstream ORFs in Eukaryotes.
Hong Zhang,Yirong Wang,Jian Lu +2 more
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TLDR
The current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics is reviewed and remaining gaps that deserve further study are addressed.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2019-09-01. It has received 86 citations till now. The article focuses on the topics: Translational regulation & Cellular homeostasis.read more
Citations
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Journal ArticleDOI
Folding the Mitochondrial UPR into the Integrated Stress Response.
TL;DR: Recent research into the mechanisms underlying UPRMT signaling in Caenorhabditis elegans are reviewed and emerging connections between the UPRmt signaling and a translational regulation program called the 'integrated stress response' are discussed.
The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs
Ulf-Peter Guenther,David E. Weinberg,David E. Weinberg,Meghan Zubradt,Meghan Zubradt,Frank A. Tedeschi,Brittany N. Stawicki,Leah L. Zagore,Gloria A. Brar,Donny D. Licatalosi,David P. Bartel,Jonathan S. Weissman,Jonathan S. Weissman,Eckhard Jankowsky +13 more
TL;DR: It is shown that the effects of Ded1p on the initiation of translation are connected to near-cognate initiation codons in 5′ untranslated regions, and this program has a role in meiosis, in which a marked decrease in the levels of Ded 1p is accompanied by the activation of the alternative translation initiation sites that are seen when the activity of Ded2p is repressed.
Journal ArticleDOI
A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome.
Doyeon Kim,Sukjun Kim,Joori Park,Hee Ryung Chang,Jeeyoon Chang,Junhak Ahn,Heedo Park,Junehee Park,Narae Son,Gihyeon Kang,Jeonghun Kim,Kisoon Kim,Man-Seong Park,Yoon Ki Kim,Daehyun Baek +14 more
TL;DR: A high-resolution atlas of the translatome and transcriptome of SARS-CoV-2 for various time points after infecting human cells is presented in this article.
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Manipulating gene translation in plants by CRISPR-Cas9-mediated genome editing of upstream open reading frames.
TL;DR: Unlike previous methods, this strategy achieves fine-tuning of gene translation in transgene-free derivatives, which accelerates the analysis of gene function and the improvement of crop traits.
Journal ArticleDOI
Metabolite Control of Translation by Conserved Peptide uORFs: The Ribosome as a Metabolite Multisensor.
TL;DR: Ribosomes translate the mRNA code into protein, and this process can be controlled by metabolites that bind to the translating ribosome in interaction with the nascent protein.
References
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Journal ArticleDOI
RNA-Seq: a revolutionary tool for transcriptomics
TL;DR: The RNA-Seq approach to transcriptome profiling that uses deep-sequencing technologies provides a far more precise measurement of levels of transcripts and their isoforms than other methods.
Journal ArticleDOI
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
TL;DR: A ribosomesome-profiling strategy based on the deep sequencing of ribosome-protected mRNA fragments is presented and enables genome-wide investigation of translation with subcodon resolution and is used to monitor translation in budding yeast under both rich and starvation conditions.
Journal ArticleDOI
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TL;DR: Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems.
Journal ArticleDOI
The mechanism of eukaryotic translation initiation and principles of its regulation
TL;DR: This work has provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).
Journal ArticleDOI
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
TL;DR: A suite of techniques, based on ribosome profiling, are presented to provide genome-wide maps of protein synthesis as well as a pulse-chase strategy for determining rates of translation elongation, revealing an unanticipated complexity to mammalian proteomes.
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