Journal ArticleDOI
Functional diversity of astrocytes in neural circuit regulation
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TLDR
An overview of the regional heterogeneity of neuron–astrocyte interactions indicates novel ways in which they could regulate normal neurological function and shows how they might become dysregulated in disease.Abstract:
Emerging evidence suggests that astrocytes may be as diverse in their physiological and functional characteristics as neurons. Ben Haim and Rowitch describe astrocyte heterogeneity, consider the mechanisms by which such diversity may arise and discuss the consequences of its disruption in disease.read more
Citations
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The role of the heat shock response in protein aggregation and neuroinflammation associated with neurodegenerative diseases
TL;DR: The aim of this book is to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
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Light microscopic and heterogeneity analysis of astrocytes in the common marmoset brain.
TL;DR: In this paper, the authors investigated the molecular and structural heterogeneity of marmoset astrocytes using an array of markers, multi-label confocal microscopy, and quantitative analysis.
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Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons
TL;DR: In this paper , the authors investigated the neuronal reprogramming capacity of CEND1 and/or Neurogenin-2 (NEUROG2 ) upon their overexpression on primary human adult cortical astrocytes.
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ACSA-2 and GLAST classify subpopulations of multipotent and glial-restricted cerebellar precursors.
Christina Geraldine Kantzer,Christina Geraldine Kantzer,Elena Parmigiani,Elena Parmigiani,Valentina Cerrato,Valentina Cerrato,Stefan Tomiuk,Michail Knauel,Melanie Jungblut,Annalisa Buffo,Andreas Bosio +10 more
TL;DR: In this article, the authors reveal that ACSA-2 is expressed by glial precursors throughout postnatal cerebellar development, including prospective white matter (PWM) cells and Bergmann glia (BG).
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Astrocytes Transplanted during Early Postnatal Development Integrate, Mature, and Survive Long Term in Mouse Cortex
TL;DR: In this article , the authors transplanted immature mouse cortical astrocytes into the developing cortex of male and female mice and assessed their integration, maturation, and survival, and found that the transplanted cells appeared morphologically mature and expressed levels of EAAT2/GLT1 similar to nontransplanted cells.
References
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Journal ArticleDOI
Astrocytes: biology and pathology
TL;DR: Astrocyte functions in healthy CNS, mechanisms and functions of reactive astrogliosis and glial scar formation, and ways in which reactive astrocytes may cause or contribute to specific CNS disorders and lesions are reviewed.
Journal ArticleDOI
Molecular dissection of reactive astrogliosis and glial scar formation.
TL;DR: Developments in the signaling mechanisms that regulate specific aspects of reactive astrogliosis are reviewed and the potential to identify novel therapeutic molecular targets for diverse neurological disorders is highlighted.
Journal ArticleDOI
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
TL;DR: The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules.
Journal ArticleDOI
Genomic Analysis of Reactive Astrogliosis
Jennifer L. Zamanian,Lijun Xu,Lynette C. Foo,Navid Nouri,Lu Zhou,Rona G. Giffard,Ben A. Barres +6 more
TL;DR: The findings provide transcriptome databases for two subtypes of reactive astrocytes that will be highly useful in generating new and testable hypotheses of their function, as well as for providing new markers to detect different types of reactiveAstrocyte reactive gliosis in human neurological diseases.
Journal ArticleDOI
Astroglia induce neurogenesis from adult neural stem cells
TL;DR: These findings reinforce the emerging view that astrocytes have an active regulatory role—rather than merely supportive roles traditionally assigned to them—in the mature central nervous system.
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