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Functional diversity of astrocytes in neural circuit regulation
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TLDR
An overview of the regional heterogeneity of neuron–astrocyte interactions indicates novel ways in which they could regulate normal neurological function and shows how they might become dysregulated in disease.Abstract:
Emerging evidence suggests that astrocytes may be as diverse in their physiological and functional characteristics as neurons. Ben Haim and Rowitch describe astrocyte heterogeneity, consider the mechanisms by which such diversity may arise and discuss the consequences of its disruption in disease.read more
Citations
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Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database
Ronglan Wu,Josifs Survilo +1 more
TL;DR: In this article , the authors used translating ribosome affinity purification together with RNA sequencing and immunohistochemistry to characterize the cortical astroglial translatome in male and female mice across postnatal development.
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Mitochondrial Dysfunction and Changes in High-Energy Compounds in Different Cellular Models Associated to Hypoxia: Implication to Schizophrenia.
Luiz Felipe Souza E Silva,Mariana Dutra Brito,Jéssica Mayumi Camargo Yuzawa,Tatiana R. Rosenstock +3 more
TL;DR: The data suggest that hypoxia can induce mitochondrial deregulation and a decrease in energy metabolism in the most prevalent cell type in the brain, astrocytes.
Journal ArticleDOI
Coordinated morphogenesis of neurons and glia.
TL;DR: The power of Drosophila and C. elegans models to study coordinated changes at defined neuron-glia contacts is explored, highlighting the use of innovative genetic and imaging tools to uncover the molecular mechanisms responsible for coordinated morphogenesis of neurons and glia.
Journal ArticleDOI
Brn2 Alone Is Sufficient to Convert Astrocytes into Neural Progenitors and Neurons.
TL;DR: It is demonstrated that Brn2 alone is sufficient to convert astrocytes into neural progenitors and neurons, and the conversion is associated with cell microenvironments.
Journal ArticleDOI
Blocking C3d<sup>+</sup>/GFAP<sup>+</sup> A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke
TL;DR: In this article , the glucagon-like peptide-1 receptor agonist semaglutide was intraperitoneally injected into mice to inhibit A1 astrocytes.
References
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Journal ArticleDOI
Astrocytes: biology and pathology
TL;DR: Astrocyte functions in healthy CNS, mechanisms and functions of reactive astrogliosis and glial scar formation, and ways in which reactive astrocytes may cause or contribute to specific CNS disorders and lesions are reviewed.
Journal ArticleDOI
Molecular dissection of reactive astrogliosis and glial scar formation.
TL;DR: Developments in the signaling mechanisms that regulate specific aspects of reactive astrogliosis are reviewed and the potential to identify novel therapeutic molecular targets for diverse neurological disorders is highlighted.
Journal ArticleDOI
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
TL;DR: The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules.
Journal ArticleDOI
Genomic Analysis of Reactive Astrogliosis
Jennifer L. Zamanian,Lijun Xu,Lynette C. Foo,Navid Nouri,Lu Zhou,Rona G. Giffard,Ben A. Barres +6 more
TL;DR: The findings provide transcriptome databases for two subtypes of reactive astrocytes that will be highly useful in generating new and testable hypotheses of their function, as well as for providing new markers to detect different types of reactiveAstrocyte reactive gliosis in human neurological diseases.
Journal ArticleDOI
Astroglia induce neurogenesis from adult neural stem cells
TL;DR: These findings reinforce the emerging view that astrocytes have an active regulatory role—rather than merely supportive roles traditionally assigned to them—in the mature central nervous system.
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