Journal ArticleDOI
Functional diversity of astrocytes in neural circuit regulation
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TLDR
An overview of the regional heterogeneity of neuron–astrocyte interactions indicates novel ways in which they could regulate normal neurological function and shows how they might become dysregulated in disease.Abstract:
Emerging evidence suggests that astrocytes may be as diverse in their physiological and functional characteristics as neurons. Ben Haim and Rowitch describe astrocyte heterogeneity, consider the mechanisms by which such diversity may arise and discuss the consequences of its disruption in disease.read more
Citations
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Journal ArticleDOI
Molecular Architecture of the Mouse Nervous System.
Amit Zeisel,Hannah Hochgerner,Peter Lönnerberg,Anna Johnsson,Fatima Memic,Job van der Zwan,Martin Häring,Emelie Braun,Lars E. Borm,Gioele La Manno,Simone Codeluppi,Alessandro Furlan,Kawai Lee,Nathan G. Skene,Kenneth D. Harris,Jens Hjerling-Leffler,Ernest Arenas,Patrik Ernfors,Ulrika Marklund,Sten Linnarsson +19 more
TL;DR: RNA sequencing of half a million single cells was used to create a detailed census of cell types in the mouse nervous system and mapped cell types spatially and derived a hierarchical, data-driven taxonomy.
Journal ArticleDOI
Reactive astrocyte nomenclature, definitions, and future directions
Carole Escartin,Elena Galea,Andras Lakatos,James P. O'Callaghan,Gabor C. Petzold,Gabor C. Petzold,Alberto Serrano-Pozo,Christian Steinhäuser,Andrea Volterra,Giorgio Carmignoto,Giorgio Carmignoto,Amit Agarwal,Nicola J. Allen,Alfonso Araque,Luis Barbeito,Ari Barzilai,Dwight E. Bergles,Gilles Bonvento,Arthur M. Butt,Wei Ting Chen,Martine Cohen-Salmon,Colm Cunningham,Benjamin Deneen,Bart De Strooper,Bart De Strooper,Blanca Diaz-Castro,Cinthia Farina,Marc R. Freeman,Vittorio Gallo,James E. Goldman,Steven A. Goldman,Steven A. Goldman,Magdalena Götz,Antonia Gutierrez,Philip G. Haydon,Dieter Henrik Heiland,Elly M. Hol,Matthew Holt,Masamitsu Iino,Ksenia V. Kastanenka,Helmut Kettenmann,Baljit S. Khakh,Schuichi Koizumi,C. Justin Lee,Shane A. Liddelow,Brian A. MacVicar,Pierre J. Magistretti,Pierre J. Magistretti,Albee Messing,Anusha Mishra,Anna V. Molofsky,Keith K. Murai,Christopher M. Norris,Seiji Okada,Stéphane H. R. Oliet,João Filipe Oliveira,João Filipe Oliveira,Aude Panatier,Vladimir Parpura,Marcela Pekna,Milos Pekny,Luc Pellerin,Gertrudis Perea,Beatriz G. Pérez-Nievas,Frank W. Pfrieger,Kira E. Poskanzer,Francisco J. Quintana,Richard M. Ransohoff,Miriam Riquelme-Perez,Stefanie Robel,Christine R. Rose,Jeffrey D. Rothstein,Nathalie Rouach,David H. Rowitch,Alexey Semyanov,Alexey Semyanov,Swetlana Sirko,Harald Sontheimer,Raymond A. Swanson,Javier Vitorica,Ina B. Wanner,Levi B. Wood,Jia Qian Wu,Binhai Zheng,Eduardo R. Zimmer,Robert Zorec,Michael V. Sofroniew,Alexei Verkhratsky,Alexei Verkhratsky +88 more
TL;DR: In this article, the authors point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic vs-neuroprotective or A1-vs.A2.
Posted ContentDOI
Molecular architecture of the mouse nervous system
Amit Zeisel,Hannah Hochgerner,Peter Lönnerberg,Anna Johnsson,Fatima Memic,Job van der Zwan,Martin Häring,Emelie Braun,Lars E. Borm,Gioele La Manno,Simone Codeluppi,Alessandro Furlan,Nathan G. Skene,Kenneth D. Harris,Jens Hjerling-Leffler,Ernest Arenas,Patrik Ernfors,Ulrika Marklund,Sten Linnarsson +18 more
TL;DR: RNA sequencing of half a million single cells is used to create a detailed census of cell types in the mouse nervous system and lays a solid foundation for understanding the molecular architecture of the mammalian nervous system, and enables genetic manipulation of specific cell types.
Journal ArticleDOI
Microglial control of astrocytes in response to microbial metabolites
Veit Rothhammer,Davis M. Borucki,Emily C. Tjon,Maisa C. Takenaka,Chun-Cheih Chao,Alberto Ardura-Fabregat,Kalil Alves de Lima,Cristina Gutiérrez-Vázquez,Patrick Hewson,Ori Staszewski,Manon Blain,Luke M. Healy,Tradite Neziraj,Matilde Borio,Michael A. Wheeler,Loic Lionel Dragin,David Laplaud,Jack P. Antel,Jorge I. Alvarez,Marco Prinz,Francisco J. Quintana,Francisco J. Quintana +21 more
TL;DR: It is reported that TGFα and VEGF-B produced by microglia regulate the pathogenic activities of astrocytes in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis, and this pathway may guide new therapies for multiple sclerosis and other neurological disorders.
Journal ArticleDOI
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence
Hua Chai,Blanca Diaz-Castro,Eiji Shigetomi,Emma Monte,J. Christopher Octeau,Xinzhu Yu,Whitaker Cohn,Whitaker Cohn,Pradeep S. Rajendran,Thomas M. Vondriska,Julian P. Whitelegge,Julian P. Whitelegge,Giovanni Coppola,Giovanni Coppola,Baljit S. Khakh +14 more
TL;DR: In this article, the authors used multiple integrated approaches, including RNA sequencing (RNA-seq), mass spectrometry, electrophysiology, immunohistochemistry, serial block-face-scanning electron microscopy, morphological reconstructions, pharmacogenetics, and diffusible dye, calcium, and glutamate imaging, to directly compare adult striatal and hippocampal astrocytes under identical conditions.
References
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Journal ArticleDOI
Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1
Lydie Morel,Melissa R. Regan,Haruki Higashimori,Seng Kah Ng,Christine Esau,Svetlana Vidensky,Jeffrey D. Rothstein,Yongjie Yang +7 more
TL;DR: A new neuron-to-astrocyte communication pathway is characterized and miRNAs that modulate GLT1 protein expression in astrocytes in vitro and in vivo are identified.
Journal ArticleDOI
Astrocytes in the damaged brain: molecular and cellular insights into their reactive response and healing potential.
TL;DR: The cellular/molecular mechanisms supporting the detrimental or beneficial features of astrogliosis have been scrutinized to gain insights on possible pharmacological approaches to enhance astrocyte neuroprotective activities.
Journal ArticleDOI
Identification of Positionally Distinct Astrocyte Subtypes whose Identities Are Specified by a Homeodomain Code
TL;DR: This article identified three positionally distinct subtypes of white-matter astrocytes (WMA) in the spinal cord, which can be distinguished by the combinatorial expression of Reelin and Slit1.
Journal ArticleDOI
Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation.
TL;DR: These findings demonstrate that the Huntington's disease mutation results in a progressively deranged glutamate handling in the brain, beginning before the onset of symptoms in mice, and provide evidence for a contribution of excitotoxicity to the pathophysiology of Huntington’s disease.
Journal ArticleDOI
Motor behavior activates Bergmann glial networks.
TL;DR: Large networks of Bergmann glia can be activated by specific animal behaviors and undergo excitation of sufficient magnitude to potentially initiate macroscopic changes in brain dynamics or blood flow.
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