Journal ArticleDOI
Gender-specific transcriptional profiling of marine medaka (Oryzias melastigma) liver upon BDE-47 exposure.
W.K. Yu,Yao-Long Shi,Chi-Chun Fong,Y. Chen,J.P. van de Merwe,Alice K.Y. Chan,Fan Wei,Jun Bo,R. Ye,Doris W.T. Au,Rudolf S.S. Wu,Mengsu Yang +11 more
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TLDR
Results revealed that in male O. melastigma only, BDE-47 exposure may activate phosphoinositide-3-kinase and mitogen-activated protein kinase, proteins that play importance roles in cell growth, proliferation and survival.About:
This article is published in Comparative Biochemistry and Physiology Part D: Genomics and Proteomics.The article was published on 2013-09-01. It has received 13 citations till now. The article focuses on the topics: Oryzias & Fibrinogen-gamma chain.read more
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Metabolomic Strategies for Aquaculture Research: A Primer
Tim Young,Andrea C. Alfaro +1 more
TL;DR: This contribution provides a review of techniques and steps necessary to conduct metabolomics research, from experimental design to data interpretation, and offers some advice on how to access relevant expertise and facilities for metabolomics-based aquaculture research.
Journal ArticleDOI
Gender-Specific Toxicological Effects of Chronic Exposure to Pure Microcystin-LR or Complex Microcystis aeruginosa Extracts on Adult Medaka Fish.
Séverine Le Manach,Nour Khenfech,Hélène Huet,Qin Qiao,Charlotte Duval,Arul Marie,Gérard Bolbach,Gilles Clodic,Chakib Djediat,Cécile Bernard,Marc Edery,Benjamin Marie +11 more
TL;DR: The results suggest that fish populations exposed to cyanobacteria blooms may potentially face several ecotoxicological issues, especially for proteins involved in metabolic and homeostasis processes.
Journal ArticleDOI
Omics of the marine medaka (Oryzias melastigma) and its relevance to marine environmental research
Bo-Mi Kim,Jaebum Kim,Ik-Young Choi,Sheikh Raisuddin,Doris W.T. Au,Kenneth M.Y. Leung,Rudolf S.S. Wu,Jae-Sung Rhee,Jae-Seong Lee +8 more
TL;DR: This review presents current omics information about the marine medaka and discusses its potential applications in the study of various molecular pathways that can be targets of marine environmental stressors, such as chemical pollutants.
Journal ArticleDOI
Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach
Qin Qiao,Séverine Le Manach,Benoit Sotton,Hélène Huet,Hélène Huet,Evelyne Duvernois-Berthet,Alain Paris,Charlotte Duval,Loïc Ponger,Arul Marie,Alain Blond,Lucrèce Mathéron,Joëlle Vinh,Gérard Bolbach,Chakib Djediat,Cécile Bernard,Marc Edery,Benjamin Marie +17 more
TL;DR: By developing an integrative approach combining histology and different high-throughput omic investigations, this work was able to globally depict the strong sexual dimorphism that concerns various cellular and molecular processes of hepatocytes comprising protein synthesis, amino acid, lipid and polysaccharide metabolism, along with steroidogenesis and detoxification.
References
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Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research
TL;DR: Blast2GO (B2G), a research tool designed with the main purpose of enabling Gene Ontology (GO) based data mining on sequence data for which no GO annotation is yet available, is presented.
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High-throughput functional annotation and data mining with the Blast2GO suite.
Stefan Götz,Juan M. García-Gómez,Javier Terol,Tim D. Williams,Shivashankar H. Nagaraj,María José Nueda,Montserrat Robles,Manuel Talon,Joaquín Dopazo,Ana Conesa +9 more
TL;DR: The Blast2GO framework is used to carry out a detailed analysis of annotation behaviour through homology transfer and its impact in functional genomics research to offer biologists useful information to take into account when addressing the task of functionally characterizing their sequence data.
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Computational analysis of microarray data
TL;DR: The management and analysis of the millions of data points that result from microarray experiments has received less attention as discussed by the authors, but the methods that are used to analyse the data can have a profound influence on the interpretation of the results.
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A Concise Guide to cDNA Microarray Analysis
Priti S. Hegde,R. Qi,Kristie Abernathy,S. Dharap,Renee Gaspard,J.E. Hughes,Erik Snesrud,Norman H. Lee,John Quackenbush +8 more
TL;DR: This work has optimized all aspects of the process, including PCR amplification of target cDNA clones, microarray printing, probe labeling and hybridization, and has developed strategies for data normalization and analysis.