Journal ArticleDOI
Generating neuronal diversity in the retina: one for nearly all.
Till Marquardt,Peter Gruss +1 more
TLDR
Retinal cell diversification is apparently not achieved by spatial prepatterning into distinct progenitor domains, but rather by the sequential production of cell types in a defined histogenetic order.About:
This article is published in Trends in Neurosciences.The article was published on 2002-01-01. It has received 364 citations till now. The article focuses on the topics: Population & Retina.read more
Citations
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Journal ArticleDOI
Late-Stage Neuronal Progenitors in the Retina Are Radial Müller Glia That Function as Retinal Stem Cells
TL;DR: It is concluded that zebrafish Müller glia function as multipotent retinal stem cells that generate retinal neurons by homeostatic and regenerative developmental mechanisms.
Journal ArticleDOI
SOX2 is a dose-dependent regulator of retinal neural progenitor competence
Olena Taranova,Scott T. Magness,B. Matthew Fagan,Yongqin Wu,Natalie Surzenko,Scott R. Hutton,Larysa H. Pevny +6 more
TL;DR: Results show that precise regulation of SOX2 dosage is critical for temporal and spatial regulation of retinal progenitor cell differentiation and provide a cellular and molecular model for understanding how hypomorphic levels ofSOX2 cause retinal defects in humans.
Journal ArticleDOI
Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes.
TL;DR: This study comprehensively analyzed the expression patterns of several transcription factors in the ventricular zone of the developing subpallium in the mouse to generate a detailed molecular map of the different progenitor domains present in this region.
Journal ArticleDOI
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.
TL;DR: A step-wise 'transcriptional dominance' model of photoreceptor cell fate determination is proposed, with the S cone representing the default state of a generic photorecept precursor.
Journal ArticleDOI
Molecular characterization of retinal stem cells and their niches in adult zebrafish.
TL;DR: The regenerative capacity of the adult zebrafish retina with its ability to replace lost retinal neurons provides an opportunity to discover the molecular regulators that lead to functional repair of damaged neural tissue.
References
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Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TL;DR: Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.
Journal ArticleDOI
Mammalian neural stem cells.
TL;DR: Before the full potential of neural stem cells can be realized, the authors need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.
Journal ArticleDOI
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
TL;DR: The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules.
Journal ArticleDOI
A common progenitor for neurons and glia persists in rat retina late in development
TL;DR: Retrovirus-mediated gene transfer was used to mark cell lineages in vivo in the postnatal rat retina, indicating that a single retinal progenitor can generate remarkably diverse cell types near the end of development.
Journal ArticleDOI
Pax-6, a murine paired box gene, is expressed in the developing CNS.
Claudia Walther,Peter Gruss +1 more
TL;DR: The expression pattern of Pax-6 during embryogenesis and the isolation of cDNA clones spanning the entire coding region are described and, in addition to the paired domain, a paired-type homeodomain is contained.