Journal ArticleDOI
Genistein modulates the expression of NF-κB and MAPK (p-38 and ERK1/2), thereby attenuating d-Galactosamine induced fulminant hepatic failure in Wistar rats.
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TLDR
Genistein may serve as a potential supplement in the prevention of hepatic and inflammatory diseases and is able to maintain the redox potential and strengthens the antioxidant defense system of a cell.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2015-03-01. It has received 82 citations till now. The article focuses on the topics: Genistein & Proinflammatory cytokine.read more
Citations
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Journal ArticleDOI
Oxidative Stress: Harms and Benefits for Human Health
Gabriele Pizzino,Natasha Irrera,Mariapaola Cucinotta,Giovanni Pallio,Federica Mannino,Vincenzo Arcoraci,Francesco Squadrito,Domenica Altavilla,Alessandra Bitto +8 more
TL;DR: In this review, the most recent findings in the oxidative stress field are described, highlighting both its bad and good sides for human health.
Journal ArticleDOI
Isoflavones: Anti-Inflammatory Benefit and Possible Caveats
TL;DR: The anti-inflammatory effects of isoflavones are summarized, the underlying mechanisms are unraveled, the potential health risks are presented, and the potential risks and benefits are presented.
Journal ArticleDOI
Bioactivity of genistein: A review of in vitro and in vivo studies
Ajaz Ahmad Ganai,Humaira Farooqi +1 more
TL;DR: At the molecular level, Genistein reduces the number of developing CD4(+) and CD8(+) thymocytes suggesting a possible mechanism for genistein effects on cell-mediated immunity, and at cellular level adipocyte differentiation is another property of genisteIn which makes it a better neutraceutical which can reduce the atherogenic condition and hypercholesterolemia.
Journal ArticleDOI
Botanicals and Their Bioactive Phytochemicals for Women's Health.
TL;DR: Although botanicals are perceived as natural safe remedies, it is important for women and their healthcare providers to realize that they have not been rigorously tested for potential toxic effects and/or drug/botanical interactions.
Journal ArticleDOI
A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives.
Robert Domitrović,Iva Potočnjak +1 more
TL;DR: Available data suggest that phytochemicals possess a various degree of modulation of specific signaling pathways, pointing out a need for usage of combinations of several hepatoprotective compounds in both experimental studies and clinical trials.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Book ChapterDOI
Microsomal lipid peroxidation.
John A. Buege,Steven D. Aust +1 more
TL;DR: This chapter discusses microsomal lipid peroxidation, a complex process known to occur in both plants and animals that involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids, and the eventual destruction of membrane lipids.
Journal ArticleDOI
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
Stanley Reitman,Sam Frankel +1 more
Journal ArticleDOI
Genistein, a specific inhibitor of tyrosine-specific protein kinases.
Tetsu Akiyama,J Ishida,Shinsaku Nakagawa,Hiroshi Ogawara,Shinya Watanabe,N Itoh,M Shibuya,Yasuo Fukami +7 more
TL;DR: Genistein inhibited the EGF-stimulated increase in phosphotyrosine level in A431 cells and scarcely inhibited the enzyme activities of serine- and threonine-specific protein kinases such as cAMP-dependent protein kinase, phosphorylase kinases, and the Ca2+/phospholipid-dependent enzymeprotein kinase C.
Journal ArticleDOI
Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
Taro Kawai,Shizuo Akira +1 more
TL;DR: The role played by TLRs in mounting protective immune responses against infection and their crosstalk with other PRRs with respect to pathogen recognition is focused on.
Related Papers (5)
Genistein attenuates D-GalN induced liver fibrosis/chronic liver damage in rats by blocking the TGF-β/Smad signaling pathways.
Ajaz Ahmad Ganai,Mohammad Husain +1 more