Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats
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Findings indicate that genistein may play a neuroprotective role in Alzheimer's disease through regulating CAMK4 to modulate tau hyperphosphorylation.About:
This article is published in Neural Regeneration Research.The article was published on 2017-09-01 and is currently open access. It has received 50 citations till now. The article focuses on the topics: Tau protein & Genistein.read more
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Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway.
TL;DR: The results suggested that Exo-cur featured highly effective BBB-crossing via receptor-mediated transcytosis to access brain tissues and inhibited Tau phosphorylation, holding great potential in improving targeted drug delivery and the recovery of neuronal function in AD therapy.
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Role of dietary polyphenols on gut microbiota, their metabolites and health benefits.
TL;DR: The role of different types and sources of dietary polyphenols on the modulation of the gut microbiota, their metabolites and how they impact on host health benefits are focused on.
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Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease.
TL;DR: The effect of curcumin on Alzheimer's disease involves multiple signaling pathways: anti-amyloid and metal iron chelating properties, antioxidation and anti-inflammatory activities.
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Emerging Signal Regulating Potential of Genistein Against Alzheimer's Disease: A Promising Molecule of Interest.
Md. Sahab Uddin,Md. Tanvir Kabir +1 more
TL;DR: This article focuses on the therapeutic effects and molecular targets of genistein, which has been found to target directly the Aβ and tau to control the intracellular signaling pathways responsible for neurons death in the AD brain.
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The impact of curcumin and its modified formulations on Alzheimer's disease.
TL;DR: The effects of curcumin and its modified formulations in human and experimental models of AD are gathered to gather the effects of the main ingredient of turmeric traditionally used in Asian medicine.
References
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The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
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Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
George G.J.M. Kuiper,Bo Carlsson,Kaj Grandien,Eva Enmark,Johan Häggblad,Stefan K. Nilsson,Jan-Åke Gustafsson +6 more
TL;DR: The messenger RNA expression of both ER subtypes in rat tissues by RT-PCR is investigated and the ligand binding specificity of the ER sub types is compared, revealing a single binding component for 16β-estradiol with high affinity.
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Amyloid-β and Tau: The Trigger and Bullet in Alzheimer Disease Pathogenesis
TL;DR: Because soluble toxic aggregates of both Aβ and tau can self-propagate and spread throughout the brain by prionlike mechanisms, successful therapeutic intervention for AD would benefit from detecting these species before plaques, tangles, and cognitive impairment become evident and from interfering with the destructive biochemical pathways that they initiate.
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Tau phosphorylation: the therapeutic challenge for neurodegenerative disease.
TL;DR: Recent developments that suggest new therapeutic strategies to prevent or reduce the progression of pathology in the tauopathies are summarized.
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Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome
TL;DR: It is shown that Abeta immunotherapy reduces not only extracellular Abeta plaques but also intracellular AbETA accumulation and most notably leads to the clearance of early tau pathology.