Journal ArticleDOI
Genome instability in interspecific cell hybrids I. Unstable expression of genes in divergent cell hybrids
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TLDR
Show that, in addition to the chromosomal instability, some hybrids display unstable expression of three genes borne on the kangaroo active maternal X chromosome, which may be co-ordinately inactivated at high frequency, then reactivated once more.Abstract:
Somatic cell hybrids between cells of widely divergent mammalian species display a range of chromosomal and genetic anomalies which may be the equivalent of the “genomic shock” phenomena observed in many plant and animal interspecific hybrids. Mouse-kangaroo hybrids show extreme segregation and fragmentation of the kangaroo chromosomes. Here 1 show that, in addition to the chromosomal instability, some hybrids display unstable expression of three genes borne on the kangaroo active maternal X chromosome. These genes (HPRT, G6PD andPGK) may be co-ordinately inactivated at high frequency, then reactivated once more. I suggest that this reversible inactivation in interspecific hybrids may be the result of an unstable change at an X inactivation centre located in the kangaroo Xq.read more
Citations
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Journal ArticleDOI
Genes on the short arm of the human X chromosome are not shared with the marsupial X.
TL;DR: The autosomal location of human Xp genes in marsupials could mean that this region either was lost from a large ancestral X chromosome in the marsupial lineage or was acquired by a small ancestral X (and perhaps Y) in the eutherian lineage.
Journal ArticleDOI
Evidence for nuclear-cytoplasmic incompatibility between Allium fistulosum and A. cepa.
TL;DR: The data and observations support the hypothesis of nuclear-cytoplasmic incompatibility interactions between the bunching and bulb onion species.
Journal ArticleDOI
Isozyme analysis of progeny derived from (Allium fistulosum ×Allium cepa) ×Allium cepa.
TL;DR: Relatively large quantities of seed were obtained from the interspecific backcross allowing, for the first time, an extensive study of the heritable traits exhibited by backcross progeny, and the probability distribution model for linked loci did not account for all of the distorted segregation ratios.
Journal ArticleDOI
Marsupial Gene Mapping and the Evolution of Mammalian Sex-Chromosome Form and Function
TL;DR: An ancient X-autosome translocation is revealed, which either removed most of the human X short-arm markers (including the putative sex determining factor) to autosomes or added this region to a smaller ancestral X.
Journal ArticleDOI
Genome Instability in interspecific cell hybrids II. Aminopterin resistance and gene amplification in lines arising from fusions of cells from divergent mammalian species
TL;DR: It is suggested that interspecific cell hybrids are predisposed to gene amplification and may also show many other types of genetic and chromosomal instability, possibly thein vitro equivalent of the “genomic shock” phenomena described for interstrain or interspecies hybrids of plants or animals.
References
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Journal ArticleDOI
Analysis of Hybrid Zones
TL;DR: Hybrid zones are narrow regions in which genetically distinct populations meet, mate, and produce hybrids, and models of parapatric speciation, and of Wright's "shifting balance," involve the formation, move ment, and modification of hybrid zones.
Journal ArticleDOI
Hybrid dysgenesis in drosophila melanogaster: a syndrome of aberrant traits including mutation, sterility and male recombination
TL;DR: There are potentially important practical implications of hybrid dysgenesis for laboratory experimentation and care should be exercised in planning experiments involving strain crosses, and evidence that at least four of the traits are not found in nonhybrids is presented.
Journal ArticleDOI
High frequency haploid production in barley (Hordeum vulgare L.).
K. J. Kasha,K. N. Kao +1 more
TL;DR: The first observations on interspecific crosses, followed by embryo culture, illustrating an equally promising method for obtaining haploids in barley and perhaps other species are reported.
Journal ArticleDOI
The molecular basis of P-M hybrid dysgenesis: the role of the P element, a P-strain-specific transposon family.
TL;DR: Observations that P elements are present in 30-50 copies per haploid genome in all P strains examined and apparently are missing entirely from all M strains examined strongly support the P factor hypothesis for the mechanistic basis of P-M hybrid dysgenesis.
Journal ArticleDOI
Chromosomal behaviour in somatic hybrids of soybean-Nicotiana glauca
TL;DR: Protoplasts of soybean and N. glauca were induced to fuse with polyethylene glycol (PEG 1540) and up to 39% of the protoplasts in the treated population were heterokaryocytes, which indicated a tendency to stick together and break into pieces in the later cell generations.
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