Journal ArticleDOI
GIRK-like and TRPC-like conductances mediate thyrotropin-releasing hormone-induced increases in excitability in thalamic paraventricular nucleus neurons
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TLDR
The data imply that TRH enhances excitability in PVT neurons via concurrently decreasing a G-protein-gated inwardly rectifying K(+) conductance and activating a cationic conductance with characteristics reminiscent of TRPC-like channels, possibly involving TRPC4/C5 subunits.About:
This article is published in Neuropharmacology.The article was published on 2013-09-01. It has received 19 citations till now. The article focuses on the topics: Low-threshold spikes & G protein-coupled inwardly-rectifying potassium channel.read more
Citations
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Journal ArticleDOI
Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease
Chansik Hong,Hyemyung Seo,Misun Kwak,Jeha Jeon,Jihoon Jang,Eui Man Jeong,Jongyun Myeong,Yu Jin Hwang,Kotdaji Ha,Min Jueng Kang,Kyu Pil Lee,Eugene C. Yi,In Gyu Kim,Ju Hong Jeon,Hoon Ryu,Hoon Ryu,Insuk So +16 more
TL;DR: Increased TRPC5 S-glutathionylation by oxidative stress and decreased TRPC1 expression contribute to neuronal damage in the striatum and may underlie neurodegeneration in Huntington's disease.
Book ChapterDOI
Actions and Regulation of Ionotropic Cannabinoid Receptors
TL;DR: This chapter focuses on cannabinoid regulation of ion channels and lays special emphasis on their action at transient receptor channels.
Journal ArticleDOI
Intrinsic properties and neuropharmacology of midline paraventricular thalamic nucleus neurons.
TL;DR: An initial survey of intrinsic and transmitter-sensitive ionic conductances that are deemed to be unique to this population of midline thalamic neurons is presented, information that is fundamental to an appreciation of the role these thalami neurons may play in normal central nervous system (CNS) physiology and in CNS disorders that involve the dorsomedial thalamus.
Journal ArticleDOI
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels
Yingmin Zhu,Yungang Lu,Yungang Lu,Chunrong Qu,Melissa R. Miller,Jinbin Tian,Dhananjay P. Thakur,Jinmei Zhu,Zixin Deng,Xianming Hu,Meng Wu,Owen B. McManus,Min Li,Xuechuan Hong,Michael X. Zhu,Huai-Rong Luo +15 more
TL;DR: Transient receptor potential canonical (TRPC) channels play important roles in a broad array of physiological functions and are involved in various diseases and have not been elucidated due to a lack of potent subtype‐specific inhibitors.
Journal ArticleDOI
Dopamine D2 Receptors in the Paraventricular Thalamus Attenuate Cocaine Locomotor Sensitization
Abigail M. Clark,Felix Leroy,Kelly M. Martyniuk,Wendy Feng,Erika McManus,Matthew R. Bailey,Jonathan A. Javitch,Jonathan A. Javitch,Peter D. Balsam,Christoph Kellendonk,Christoph Kellendonk +10 more
TL;DR: The findings suggest the importance of PVT inhibition by D2Rs in modulating the sensitivity to cocaine, a finding that may have novel implications for human drug use.
References
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Journal ArticleDOI
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hiroshi Hibino,Atsushi Inanobe,Kazuharu Furutani,Shingo Murakami,Ian Findlay,Yoshihisa Kurachi +5 more
TL;DR: The crystal structure of different Kir channels is opening the way to understanding the structure-function relationships of this simple but diverse ion channel family.
Journal ArticleDOI
SLEEP AND AROUSAL: Thalamocortical Mechanisms
David A. McCormick,Thierry Bal +1 more
TL;DR: The release of several different neurotransmitters from the brain stem, hypothalamus, basal forebrain, and cerebral cortex results in a depolarization of thalamocortical and thalamic reticular neurons and an enhanced excitability in many cortical pyramidal cells, thereby suppressing the generation of sleep rhythms and promoting a state that is conducive to sensory processing and cognition.
Journal ArticleDOI
The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness
TL;DR: The present account provides an overview of the results of neuroanatomical tracing studies on the connections of the individual intralaminar and midline thalamic nuclei in the rat, that have been performed over the past decade in the laboratory, and concludes that the midline and intralami nuclei can be clustered into four groups.
Journal ArticleDOI
TRPC1 and TRPC5 form a novel cation channel in mammalian brain.
TL;DR: It is demonstrated here that TRPC1 and TRPC5 are subunits of a heteromeric neuronal channel, and proposed that many TRPC heteromers form diverse receptor-regulated nonselective cation channels in the mammalian brain.
Journal ArticleDOI
Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain.
Takuya Notomi,Ryuichi Shigemoto +1 more
TL;DR: The results indicate that HCNs are localized not only in somato‐dendritic compartments but also in axonal compartments of neurons and further suggest unexpected roles of Ih channels in the brain.
Related Papers (5)
Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels
Paraventricular thalamic nucleus: subcortical connections and innervation by serotonin, orexin, and corticotropin-releasing hormone in macaque monkeys.
David T. Hsu,Joseph L. Price +1 more