Global pandemics interconnected - obesity, impaired metabolic health and COVID-19.
Reads0
Chats0
TLDR
In this paper, the authors highlight how obesity and impaired metabolic health increase complications and mortality in COVID-19 and summarize the consequences of SARS-CoV-2 infection for organ function and risk of NCDs.Abstract:
Obesity and impaired metabolic health are established risk factors for the non-communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease, neurodegenerative diseases, cancer and nonalcoholic fatty liver disease, otherwise known as metabolic associated fatty liver disease (MAFLD). With the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), obesity and impaired metabolic health also emerged as important determinants of severe coronavirus disease 2019 (COVID-19). Furthermore, novel findings indicate that specifically visceral obesity and characteristics of impaired metabolic health such as hyperglycaemia, hypertension and subclinical inflammation are associated with a high risk of severe COVID-19. In this Review, we highlight how obesity and impaired metabolic health increase complications and mortality in COVID-19. We also summarize the consequences of SARS-CoV-2 infection for organ function and risk of NCDs. In addition, we discuss data indicating that the COVID-19 pandemic could have serious consequences for the obesity epidemic. As obesity and impaired metabolic health are both accelerators and consequences of severe COVID-19, and might adversely influence the efficacy of COVID-19 vaccines, we propose strategies for the prevention and treatment of obesity and impaired metabolic health on a clinical and population level, particularly while the COVID-19 pandemic is present.read more
Citations
More filters
Journal ArticleDOI
A global view of the interplay between non-alcoholic fatty liver disease and diabetes.
Norbert Stefan,Kenneth Cusi +1 more
TL;DR: In this article , the authors discuss the major mechanisms that are involved in the pathogenesis of NAFLD and type 2 diabetes, and discuss whether these mechanisms place NA FLD in an important position to better understand the pathogenic of NCDs and communicable diseases, such as COVID-19.
Journal ArticleDOI
COVID-19 and metabolic disease: mechanisms and clinical management.
Charlotte Steenblock,Peter Schwarz,Barbara Ludwig,Andreas Linkermann,Paul Zimmet,Konstantin Y. Kulebyakin,Vsevolod A. Tkachuk,Alexander G. Markov,Hendrik Lehnert,Martin Hrabě de Angelis,Hannes Rietzsch,Roman N. Rodionov,Kamlesh Khunti,David Hopkins,Andreas L. Birkenfeld,Bernhard O. Boehm,Richard I. G. Holt,Jay S. Skyler,J. Hans DeVries,Eric Renard,Robert H. Eckel,K. George M.M. Alberti,Bruno Geloneze,Juliana C.N. Chan,Jean Claude Mbanya,Henry Chijioke Onyegbutulem,Ambady Ramachandran,Abdul Basit,Mohamed Hassanein,Gavin A. Bewick,Giatgen A. Spinas,Felix Beuschlein,Rüdiger Landgraf,Francesco Rubino,Geltrude Mingrone,Stefan R. Bornstein +35 more
TL;DR: In this paper, the authors provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19 and post-pandemic.
Journal ArticleDOI
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients
Min-Qiang Wang,Yiran Yang,Jihong Min,Yu Song,Jiaobing Tu,Daniel Mukasa,Cui Ye,Changhao Xu,Nicole Heflin,Jeannine S McCune,Tzung K. Hsiai,Zhaoping Shelley Li,Wei Gao +12 more
TL;DR: In this paper , a wearable electrochemical biosensor for the continuous analysis, in sweat during physical exercise and at rest, of trace levels of multiple metabolites and nutrients, including all essential amino acids and vitamins.
Journal ArticleDOI
An Update on the Epidemiology of Type 2 Diabetes: A Global Perspective.
Maria Tinajero,Vasanti S. Malik +1 more
TL;DR: In this paper, the role of genes, early-life exposures, and lifestyle risk factors in the cause of Type 2 diabetes is discussed, with an emphasis on populations in current hotspots of the epidemic, and potential impacts of the coronavirus disease 2019 pandemic and T2D prevention policies and action.
Journal ArticleDOI
Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of fatigue in postacute sequelae of SARS-CoV-2 infection (PASC) patients.
Joseph E. Herrera,William Niehaus,Jonathan Whiteson,Alba Azola,John M. Baratta,Talya K. Fleming,Soo Yeon Kim,Huma Naqvi,Sarah Sampsel,Julie K. Silver,Monica Verduzco Gutierrez,Jason H. Maley,Eric Herman,Benjamin A. Abramoff +13 more
TL;DR: The American Academy of Physical Medicine and Rehabilitation (AAPM&R) Multi-Disciplinary PASC Collaborative as discussed by the authors developed consensus guidance on assessment and treatment recommendations for a series of Consensus Guidance Statements focused on the most prominent PASC symptoms.
References
More filters
Journal ArticleDOI
Healthy immunity: it’s all about immune regulation
TL;DR: This study presents a probabilistic approach to assess the phytochemical properties of polypeptide A, which has shown promise in finding its application in medicine and wound healing.
Journal ArticleDOI
Audio Interview: The Impact of Covid-19 on Patients with Other Diseases, with Arnold Epstein.
TL;DR: The Impact of Covid-19 on Patients with Other Diseases, with Arnold Epstein
Journal ArticleDOI
Legal Interventions to Address US Reductions in Life Expectancy.
TL;DR: This Viewpoint discusses ways that evidence-based laws can address health disparities and halt the documented reduction of life expectancy across socioeconomic groups.
Related Papers (5)
Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more