Global pandemics interconnected - obesity, impaired metabolic health and COVID-19.
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TLDR
In this paper, the authors highlight how obesity and impaired metabolic health increase complications and mortality in COVID-19 and summarize the consequences of SARS-CoV-2 infection for organ function and risk of NCDs.Abstract:
Obesity and impaired metabolic health are established risk factors for the non-communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease, neurodegenerative diseases, cancer and nonalcoholic fatty liver disease, otherwise known as metabolic associated fatty liver disease (MAFLD). With the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), obesity and impaired metabolic health also emerged as important determinants of severe coronavirus disease 2019 (COVID-19). Furthermore, novel findings indicate that specifically visceral obesity and characteristics of impaired metabolic health such as hyperglycaemia, hypertension and subclinical inflammation are associated with a high risk of severe COVID-19. In this Review, we highlight how obesity and impaired metabolic health increase complications and mortality in COVID-19. We also summarize the consequences of SARS-CoV-2 infection for organ function and risk of NCDs. In addition, we discuss data indicating that the COVID-19 pandemic could have serious consequences for the obesity epidemic. As obesity and impaired metabolic health are both accelerators and consequences of severe COVID-19, and might adversely influence the efficacy of COVID-19 vaccines, we propose strategies for the prevention and treatment of obesity and impaired metabolic health on a clinical and population level, particularly while the COVID-19 pandemic is present.read more
Citations
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A global view of the interplay between non-alcoholic fatty liver disease and diabetes.
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An Update on the Epidemiology of Type 2 Diabetes: A Global Perspective.
Maria Tinajero,Vasanti S. Malik +1 more
TL;DR: In this paper, the role of genes, early-life exposures, and lifestyle risk factors in the cause of Type 2 diabetes is discussed, with an emphasis on populations in current hotspots of the epidemic, and potential impacts of the coronavirus disease 2019 pandemic and T2D prevention policies and action.
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Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of fatigue in postacute sequelae of SARS-CoV-2 infection (PASC) patients.
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TL;DR: The American Academy of Physical Medicine and Rehabilitation (AAPM&R) Multi-Disciplinary PASC Collaborative as discussed by the authors developed consensus guidance on assessment and treatment recommendations for a series of Consensus Guidance Statements focused on the most prominent PASC symptoms.
References
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