Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes.
TLDR
This comprehensive review summarizes fundamental principles of glutathione catalysis and compares the structures and mechanisms ofglutathione-dependent enzymes, including glutathion reductase, glutaredoxins, glutATHione peroxidases, peroxiredoxinases, glyoxalases 1 and 2, glutthione transferases and MAPEG.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-05-01 and is currently open access. It has received 814 citations till now. The article focuses on the topics: Glutaredoxin & Glutathione reductase.read more
Citations
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Oxidative Stress: Harms and Benefits for Human Health
Gabriele Pizzino,Natasha Irrera,Mariapaola Cucinotta,Giovanni Pallio,Federica Mannino,Vincenzo Arcoraci,Francesco Squadrito,Domenica Altavilla,Alessandra Bitto +8 more
TL;DR: In this review, the most recent findings in the oxidative stress field are described, highlighting both its bad and good sides for human health.
Journal ArticleDOI
Oxidative Stress in Cancer.
TL;DR: During progression and metastasis, tumor cells adapt to oxidative stress by increasing NADPH in various ways, including activation of AMPK, the PPP, and reductive glutamine and folate metabolism.
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The role of glutathione reductase and related enzymes on cellular redox homoeostasis network.
TL;DR: The role of glutathione reductase in the regulation, modulation and maintenance of cellular redox homoeostasis, and therapeutic targets to overcome oxidative stress associated cellular disorders are evaluated.
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» Сибирского отделения Российской академии медицинских наук, Кемерово, Россия
S. V. Ivanov,A. N. Sumin,Y. V. Kazachek,D. E. Philipiev,S. M. Gusev,E. S. Malyshenko,L. S. Barbarash +6 more
TL;DR: The outcomes of CAD surgical treatment were improved in this group of patients due to the implementation of a mul-assisted revascularization of coronary and non-coronary arteries.
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N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why
Giancarlo Aldini,Alessandra Altomare,Giovanna Baron,Giulio Vistoli,Marina Carini,Luisa Borsani,Francesco Sergio +6 more
TL;DR: The disulphide breaking activity of NAC also explains its mucolytic activity which is due to its effect in reducing heavily cross-linked mucus glycoproteins and free thiols as well as reduced proteins which have important direct antioxidant activity.
References
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Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.
D B Smith,Kevin S. Johnson +1 more
TL;DR: Plasmid expression vectors have been constructed that direct the synthesis of foreign polypeptides in Escherichia coli as fusions with the C terminus of Sj26, a 26-kDa glutathione S-transferase (GST; EC 2.5.1.18) encoded by the parasitic helminth Schistosoma japonicum.
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The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Karen Bedard,Karl-Heinz Krause +1 more
TL;DR: This review summarizes the current state of knowledge of the functions of NOX enzymes in physiology and pathology.
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Global analysis of protein localization in budding yeast
Won-Ki Huh,James V. Falvo,Luke C. Gerke,Adam S. Carroll,Russell W. Howson,Jonathan S. Weissman,Erin K. O'Shea +6 more
TL;DR: The construction and analysis of a collection of yeast strains expressing full-length, chromosomally tagged green fluorescent protein fusion proteins helps reveal the logic of transcriptional co-regulation, and provides a comprehensive view of interactions within and between organelles in eukaryotic cells.
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Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.
TL;DR: Estimates can be used to more fully understand the redox biochemistry that results from oxidative stress, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress.