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GPX4-independent ferroptosis—a new strategy in disease’s therapy
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This article is published in Cell death discovery.The article was published on 2022-10-30. It has received 7 citations till now. The article focuses on the topics: Medicine.read more
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Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: A review.
Da Zhao,Kailin Yang,Huan Guo,Jinsong Zeng,Shanshan Wang,Hao Xu,Anqi Ge,Liuting Zeng,Jinwen Ge +8 more
TL;DR: In this paper , a review summarizes the mechanism of ferroptosis in Alzheimer's disease and the regulation of natural plant products on the effect of such a condition on AD, in order to provide reference information for future research on the development of inhibitors.
Journal ArticleDOI
Ferroptosis: Promising approach for cancer and cancer immunotherapy.
Shuyue Zheng,Xin-Yuan Guan +1 more
TL;DR: In this paper , the authors focus on the mechanism of ferroptosis and its interaction with cancer and tumor immune microenvironment, especially for the relationship between immune cells and ferrosinosis.
Journal ArticleDOI
The role of Hippo pathway in ferroptosis
TL;DR: The role of Hippo pathway in ferroptosis was investigated in this article , where the authors provided ideas for the regulation of cell fate and the treatment of tumors, which is a regulated form of cell death characterized by the accumulation of irondependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs).
Journal ArticleDOI
Recent advances in regulating Lipid Metabolism to prevent Coronary Heart Disease.
TL;DR: In this paper , a comprehensive review of basic and clinical studies of coronary heart disease is presented, where various intervention pathways and therapeutic methods, such as the regulation of lipoprotein enzymes, lipid metabolites, and lipophrotein regulatory factors, as well as the modulation of intestinal microflora and the inhibition of ferroptosis, are proposed.
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Construction of mPEI/pGPX4 gene therapeutic system for the effective treatment of acute lung injury
TL;DR: Wang et al. as discussed by the authors used mannitol-modified polyethyleneimine (mPEI) to up-regulate the gene expression of Glutathione peroxidase (GPX4) palys, which plays an important role in the inflammatory reaction, and improved the gene therapeutic effect.
References
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Journal ArticleDOI
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
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Regulation of Ferroptotic Cancer Cell Death by GPX4
Wan Seok Yang,Rohitha SriRamaratnam,Matthew Welsch,Kenichi Shimada,Rachid Skouta,Vasanthi S. Viswanathan,Vasanthi S. Viswanathan,Jaime H. Cheah,Paul A. Clemons,Alykhan F. Shamji,Clary B. Clish,Lewis M. Brown,Albert W. Girotti,Virginia W. Cornish,Stuart L. Schreiber,Brent R. Stockwell +15 more
TL;DR: Targeted metabolomic profiling and chemoproteomics revealed that GPX4 is an essential regulator of ferroptotic cancer cell death and sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPx4-regulated ferroPTosis.
Journal ArticleDOI
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell,José Pedro Friedmann Angeli,Hülya Bayır,Ashley I. Bush,Marcus Conrad,Scott J. Dixon,Simone Fulda,Susan Gascon,Stavroula K. Hatzios,Valerian E. Kagan,Kay Noel,Xuejun Jiang,Andreas Linkermann,Maureen E. Murphy,Michael Overholtzer,Atsushi Oyagi,Gabriela Carolina Pagnussat,Jason Park,Qitao Ran,Craig S. Rosenfeld,Konstantin Salnikow,Daolin Tang,Daolin Tang,Frank M. Torti,Suzy V. Torti,Shinya Toyokuni,K. A. Woerpel,Donna D. Zhang +27 more
TL;DR: The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended.
Journal ArticleDOI
Ferroptosis as a p53-mediated activity during tumour suppression
TL;DR: It is shown that p53 inhibits cystine uptake and sensitizes cells to ferroptosis, a non-apoptotic form of cell death, by repressing expression of SLC7A11, a key component of the Cystine/glutamate antiporter.
Journal ArticleDOI
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Sebastian Doll,Bettina Proneth,Yulia Y. Tyurina,Elena Panzilius,Sho Kobayashi,Irina Ingold,Martin Irmler,Johannes Beckers,Michaela Aichler,Axel Walch,Holger Prokisch,Dietrich Trümbach,Gaowei Mao,Feng Qu,Hülya Bayır,Joachim Füllekrug,Christina Scheel,Wolfgang Wurst,Joel A. Schick,Valerian E. Kagan,José Pedro Friedmann Angeli,Marcus Conrad +21 more
TL;DR: Pharmacological targeting of ACSL4 with thiazolidinediones, a class of antidiabetic compound, ameliorated tissue demise in a mouse model of ferroptosis, suggesting that ACSL 4 inhibition is a viable therapeutic approach to preventing ferroPTosis-related diseases.