Gut microbiome variation is associated to Multiple Sclerosis phenotypic subtypes
Tatjana Reynders,Lindsay Devolder,Lindsay Devolder,Mireia Valles-Colomer,Ann Van Remoortel,Marie Joossens,Jacques De Keyser,Guy Nagels,Marie B. D'hooghe,Jeroen Raes +9 more
TLDR
Diversity, enterotypes, and specific gut microbial taxa variation between MS and HC, and between MS subgroups are studied.Abstract:
Objective Multiple sclerosis (MS) is a heterogenous, inflammatory disease of the central nervous system. Microbiota alterations in MS versus healthy controls (HC) are observed, but results are inconsistent. We studied diversity, enterotypes, and specific gut microbial taxa variation between MS and HC, and between MS subgroups. Methods Amplicon sequencing of the 16S ribosomal RNA V4 region (Illumina MiSeq) was used to evaluate alpha and beta diversity, enterotypes, and relative taxa abundances on stool samples. MS subgroups were based on phenotype, disease course modifiers, and treatment status. Results were controlled for recently identified confounders of microbiota composition. Results Ninety-eight MS patients and 120 HC were included. Microbial richness was lower in interferon-treated (RRMS_I, N = 24) and untreated relapsing-remitting MS during relapse (RRMS_R, N = 4) when compared to benign (BMS, N = 20; Z = -3.07, Pcorr = 0.032 and Z = -2.68, Pcorr = 0.055) and primary progressive MS (PPMS, N = 26; Z = -2.39, Pcorr = 0.062 and Z = -2.26, Pcorr = 0.071). HC (N = 120) and active untreated MS (RRMS_U, N = 24) showed intermediate microbial richness. Enterotypes were associated with clinical subgroups (N = 218, chi(2) = 36.10, P = 0.002), with Bacteroides 2 enterotype being more prevalent in RRMS_I. Butyricicoccus abundance was lower in PPMS than in RRMS_U (Z = -3.00, Pcorr = 0.014) and BMS (Z = -2.56, Pcorr = 0.031), lower in RRMS_I than in BMS (Z = -2.50, Pcorr = 0.034) and RRMS_U (Z = -2.91, Pcorr = 0.013), and inversely correlated with self-reported physical symptoms (rho = -0.400, Pcorr = 0.001) and disease severity (rho = -0.223, P = 0.027). Interpretation These results emphasize the importance of phenotypic subcategorization in MS-microbiome research, possibly explaining previous result heterogeneity, while showing the potential for specific microbiome-based biomarkers for disease activity and severity.read more
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Gut Microbiome in Progressive Multiple Sclerosis.
Laura M. Cox,Amir-Hadi Maghzi,Shirong Liu,Stephanie K. Tankou,Fyonn H Dhang,Valerie Willocq,Anya Song,Caroline Wasén,Shahamat Tauhid,Renxin Chu,Mark C. Anderson,Philip L. De Jager,Mariann Polgar-Turcsanyi,Brian C. Healy,Bonnie I. Glanz,Rohit Bakshi,Tanuja Chitnis,Howard L. Weiner +17 more
TL;DR: In this paper, the authors investigated the Gut Microbiota in progressive multiple sclerosis (MS) and how it relates to clinical disease and found that Akkermansia was linked to lower disability, suggesting a beneficial role.
Journal ArticleDOI
Mining microbes for mental health: Determining the role of microbial metabolic pathways in human brain health and disease.
Simon Spichak,Thomaz F.S. Bastiaanssen,Kirsten Berding,Klára Vlčková,Gerard Clarke,Timothy G. Dinan,John F. Cryan +6 more
TL;DR: In this article, the authors identified 278 studies relating to the human microbiota-gut-brain axis which included sequencing data and found evidence of disease-related alterations in microbial metabolic pathways in Alzheimer's Disease, schizophrenia, anxiety and depression.
Journal ArticleDOI
Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course
TL;DR: In this paper , the authors propose a method to solve the problem of homonymity of homophily in the context of homology.of homophysics.of.of
Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course
Xiang Zhao,Ryan Baumann,Xiaohui Gao,Myra Mendoza,Sneha Singh,Ilana Katz Sand,Zongqi Xia,Laura M. Cox,Tanuja Chitnis,Hongsup Yoon,L Moles,Stacy J. Caillier,Adam Santaniello,Gail Ackermann,Adil Harroud,Robin R. Lincoln,Refujia Gomez,Antonio Gonzalez Peña,Elise Digga,Daniel Hakim,Yoshiki Vázquez-Baeza,Karthik Soman,Shannon Warto,Gregory Humphrey,Mauricio F. Farez,Lisa Ann Gerdes,Jorge R. Oksenberg,Scott S. Zamvil,Siddharthan Chandran,P Connick,David Otaegui,Tamara Castillo-Triviño,Stephen L. Hauser,Jeffrey A. Gelfand,Howard L. Weiner,M. Hohlfeld,Hartmut Wekerle,Jennifer Graves,Amit Bar-Or,Bruce A.C. Cree,Jorge Correale,Rob Knight,Sergio E. Baranzini +42 more
TL;DR: The results strongly support specific gut microbiome associations with MS risk, course and progression, and functional changes in response to treatment as well as therapeutic activity of interferon-β.
Journal ArticleDOI
Gut microbiome alpha-diversity is not a marker of Parkinson’s disease and multiple sclerosis
Jonathan Plassais,Guillaume Gbikpi-Benissan,Marine Figarol,Filip Scheperjans,Guy Gorochov,Pascal Derkinderen,Alessandra C. L. Cervino +6 more
TL;DR: This is the first report investigating systematically alpha-diversity and its potential link to neurological disorders and it is demonstrated that unlike in other gastro-intestinal, immune and metabolic disorders, loss of bacterial diversity is not associated with Parkinson's disease and multiple sclerosis.
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