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Handbook of Biological Physics
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The article was published on 1996-01-01 and is currently open access. It has received 1088 citations till now.read more
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Journal ArticleDOI
The neurovascular retina in retinopathy of prematurity.
TL;DR: Using a combination of non-invasive electroretinographic, psychophysical, and image analysis procedures, the neural retina and its vasculature have been studied in prematurely born human subjects, with and without ROP, and in rats that model the key vascular and neural parameters found in human ROP subjects.
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Topology Mapping of the Amino-terminal Half of Multidrug Resistance-associated Protein by Epitope Insertion and Immunofluorescence
Christina Kast,Philippe Gros +1 more
TL;DR: Results indicate that the amino terminus of MRP is extracellular, while the linker segment joining the first and second membrane-associated regions is intracellular as is the first nucleotide-binding domain.
Journal ArticleDOI
Evaluation of bottlenecks in the late stages of protein secretion in Bacillus subtilis
Albert Bolhuis,Harold Tjalsma,Hilde E. Smith,Anne de Jong,Rob Meima,Gerard Venema,Sierd Bron,Jan Maarten van Dijl +7 more
TL;DR: investigated and compared bottlenecks in the secretion of four heterologous proteins: Bacillus lichenifomis α-amylase (AmyL),Escherichia coli TEM β-lactamase (Bla), human pancreatic α- amylases (HPA), and a lysozyme-specific single-chain antibody, and strikingly, all translocated HPA was misfolded, suggesting that the disulfide bond oxidoreductases
Journal ArticleDOI
Single-molecule diffusion measurements of H-Ras at the plasma membrane of live cells reveal microdomain localization upon activation.
TL;DR: This activation-dependent localization of H-Ras to 200 nm domains, for the first time directly detected in live cells, supports the proposed relationship between H- Ras microdomain localization and activation.
Journal ArticleDOI
Pattern formation during T-cell adhesion.
TL;DR: A statistical-mechanical model of T-cell pattern formation is presented which confirms the observation that the intermediate inverted pattern may be formed by spontaneous self-assembly, and finds a different self- assembly mechanism in which numerous TCR/MHCp microdomains initially nucleate throughout the contact zone.