Journal ArticleDOI
HER2-positive breast cancer
Sibylle Loibl,Luca Gianni +1 more
TLDR
New treatments in the past decade have clearly improved the prognosis of HER2-positive breast cancer, however, the persisting high toll of deaths resulting from Her2- positive breast cancer calls for continued, intensive clinical research of newer therapies and combinations.About:
This article is published in The Lancet.The article was published on 2017-06-17. It has received 527 citations till now. The article focuses on the topics: Pertuzumab & Breast cancer.read more
Citations
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The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy.
TL;DR: The authors advocate the need to assess a combination of immune determinants and the importance of evaluating the functional status of specific cell populations to increase prognostic and/or predictive power.
Journal ArticleDOI
Prognostic and predictive biomarkers in breast cancer: Past, present and future
TL;DR: Current research is focusing on tumor and circulating DNA and RNA and mutational status of ER (ESR1) for predicting the emergence of resistance to aromatase inhibitors and circulating tumor cells.
Journal ArticleDOI
Fibroblast growth factor receptors as treatment targets in clinical oncology
TL;DR: The clinical experience with FGFR inhibitors to date is described, and key aspects that might lead to improved response rates and/or the avoidance of acquired resistance are highlighted, including the selection of patients who are most likely to benefit from treatment, and the use ofFGFR inhibitors in combination regimens with other agents.
Journal ArticleDOI
Breast Cancer Molecular Stratification: From Intrinsic Subtypes to Integrative Clusters
TL;DR: This stratification of breast cancers into integrative clusters reveals prototypical patterns of single-nucleotide variants and is associated with distinct clinical courses and response to therapy.
Journal ArticleDOI
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy.
TL;DR: How MAPK-AMPK signalings interplay with each other in cancer biology is summarized, its implications in clinic cancer treatment with MAPK inhibition and AMPK modulators are discussed, and the exploitation of combinatory therapies targeting both MAPK and AM PK as a novel therapeutic intervention is discussed.
References
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Journal ArticleDOI
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
Dennis J. Slamon,Gary M. Clark,Steven G. Wong,Wendy J. Levin,Axel Ullrich,William L. McGuire +5 more
TL;DR: Amplification of the HER-2/neu gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer, and had greater prognostic value than most currently used prognostic factors in lymph node-positive disease.
Journal ArticleDOI
Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2
Dennis J. Slamon,Brian Leyland-Jones,Steven Shak,Hank Fuchs,Virginia E. Paton,Alex Bajamonde,Thomas Fleming,Wolfgang Eiermann,Janet M. Wolter,Mark D. Pegram,José Baselga,Larry Norton +11 more
TL;DR: The addition of trastuzumab to chemotherapy was associated with a longer time to disease progression, a higher rate of objective response, a longer duration of response, and a lower rate of death at 1 year.
Journal ArticleDOI
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
Edward H. Romond,Edith A. Perez,John Bryant,Vera J. Suman,Charles E. Geyer,Nancy E. Davidson,Elizabeth Tan-Chiu,Silvana Martino,Soonmyung Paik,Peter A. Kaufman,Sandra M. Swain,Thomas M. Pisansky,Louis Fehrenbacher,Leila A. Kutteh,Victor G. Vogel,Daniel W. Visscher,Greg Yothers,Robert B. Jenkins,Ann M. Brown,S. R. Dakhil,Eleftherios P. Mamounas,Wilma L. Lingle,Pamela M. Klein,James N. Ingle,Norman Wolmark +24 more
TL;DR: Tastuzumab combined with paclitaxel after doxorubicin and cyclophosphamide improves outcomes among women with surgically removed HER2-positive breast cancer.
Journal ArticleDOI
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
Martine Piccart-Gebhart,Marion Procter,Brian Leyland-Jones,Aron Goldhirsch,Michael Untch,Ian E. Smith,Luca Gianni,José Baselga,Richard Bell,Christian Jackisch,David Cameron,Mitch Dowsett,Carlos H. Barrios,Günther G. Steger,Chiun-Shen Huang,Martin Andersson,Moshe Inbar,Mikhail Lichinitser,István Láng,U. Nitz,Hiroji Iwata,C Thomssen,Caroline Lohrisch,Thomas M. Suter,Josef Rüschoff,Tamás Süto ý,Victoria Greatorex,Carol Ward,Eleanor McFadden,M. Stella Dolci,Richard D. Gelber +30 more
TL;DR: One year of treatment with trastuzumab after adjuvant chemotherapy significantly improves disease-free survival among women with HER2-positive breast cancer.
Journal ArticleDOI
Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer
Charles E. Geyer,John K. Forster,Deborah Lindquist,Stephen Chan,C. Gilles Romieu,Tadeusz Pienkowski,Agnieszka Jagiełło-Gruszfeld,John Crown,Arlene Chan,Bella Kaufman,Dimosthenis Skarlos,Mario Campone,Neville Davidson,Mark S. Berger,Cristina Oliva,Stephen D. Rubin,S. Stein,David Cameron +17 more
TL;DR: Lapatinib plus capecitabine is superior to cape citabine alone in women with HER2-positive advanced breast cancer that has progressed after treatment with regimens that included an anthracycline, a taxane, and trastuzumab.
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