High prevalence of HIV-1 drug resistance among patients on first-line antiretroviral treatment in Lomé, Togo
Anoumou Y. Dagnra,Nicole Vidal,Akovi Mensah,Akouda Patassi,Komi Aho,Mounerou Salou,Marjorie Monleau,Mireille Prince-David,Assétina Singo,Palokinam Pitché,Eric Delaporte,Martine Peeters +11 more
TLDR
The high number of resistant strains observed in Togo shows clearly that the emergence of HIV drug resistance is of increasing concern in countries where ART is now widely used, and can compromise the long-term success of first- and second-line ART.Abstract:
With widespread use of antiretroviral (ARV) drugs in Africa, one of the major potential challenges is the risk of emergence of ARV drug-resistant HIV strains. Our objective is to evaluate the virological failure and genotypic drug-resistance mutations in patients receiving first-line highly active antiretroviral therapy (HAART) in routine clinics that use the World Health Organization public health approach to monitor antiretroviral treatment (ART) in Togo.read more
Citations
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Nationwide Estimates of Viral Load Suppression and Acquired HIV Drug Resistance in Cameroon.
Gaëlle F. Tchouwa,Sabrina Eymard-Duvernay,Amandine Cournil,Nadine Lamare,Laetitia Serrano,Christelle Butel,Silvia Bertagnolio,Eitel Mpoudi-Ngole,Elliot Raizes,Avelin F. Aghokeng +9 more
TL;DR: Results of this first nationwide study indicate alarming levels of virological failure and ADR in Cameroon and better ART management is urgently needed and should focus on improving ART adherence, availability of VL monitoring, and more timely switches to second-line ART.
Journal ArticleDOI
Prevalence of HIV-1 drug resistance among patients failing first-line ART in Monrovia, Liberia: a cross-sectional study
Paul Loubet,Charlotte Charpentier,Benoit Visseaux,Abraham Borbor,Cecilia Nuta,Eric Adu,Jean-Marc Chapplain,Maima Baysah,Pierre Tattevin,Yazdan Yazdanpanah,Diane Descamps,Diane Descamps +11 more
TL;DR: The high prevalence of acquired drug resistance in patients followed in two centres of the Liberian capital city, documented after a median of 3 years on a first-line ART regimen, jeopardizes the activity of second-line regimens and highlights the need for virological monitoring in these settings.
HIV, Biomedical Prevention, and the Performativity of the Law
TL;DR: In this article, the authors consider the operation of various framing devices that attribute responsibility and causation with regard to HIV events and propose that we need to sharp-en our analytic focus on what these devices do, their performativity, their full range of societal impli- cations and effects.
Journal ArticleDOI
Spatiotemporal dynamics of the HIV-1 CRF06_cpx epidemic in Western Africa.
Edson Delatorre,Gonzalo Bello +1 more
TL;DR: The CRF06_cpx epidemic in western Africa probably emerged at the late 1970s and grew during the 1980s at a rate comparable to the HIV-1 epidemics in the United States and Europe.
Journal ArticleDOI
Antiretroviral Resistance After First-Line Antiretroviral Therapy Failure in Diverse HIV-1 Subtypes in the SECOND-LINE Study.
Edward Patrick Lam,Cecilia L. Moore,Eduardo Gotuzzo,Chidi Nwizu,Adeeba Kamarulzaman,Ploenchan Chetchotisakd,Jean van Wyk,Hedy Teppler,Nagalingeswaran Kumarasamy,Jean-Michel Molina,Sean Emery,David A. Cooper,Mark A. Boyd,Mark A. Boyd +13 more
TL;DR: In this paper, the authors investigate mutations and correlates according to HIV-1 subtype after virological failure (VF) of standard first-line antiretroviral therapy (ART) (non-nucleoside/nucleotide reverse transcriptase inhibitor [NNRTI] +2 nucleoside or nucleotide Reverse transcriptase inhibitors [N(t)RTI]).
References
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