Journal ArticleDOI
The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings
Charles F. Gilks,Siobhan Crowley,Rene Ekpini,Sandy Gove,Jos Perriens,Yves Souteyrand,Don Sutherland,Marco Vitoria,Teguest Guerma,Kevin M. De Cock +9 more
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TLDR
A public-health approach to antiretroviral therapy (ART) to enable scaling-up access to treatment for HIV-positive people in developing countries, recognising that the western model of specialist physician management and advanced laboratory monitoring is not feasible in resource-poor settings.About:
This article is published in The Lancet.The article was published on 2006-08-05. It has received 674 citations till now. The article focuses on the topics: Health policy & Population.read more
Citations
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Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model
TL;DR: A theoretical strategy of universal voluntary HIV testing and immediate treatment with ART, combined with present prevention approaches, could have a major effect on severe generalised HIV/AIDS epidemics.
Journal ArticleDOI
Improving the prevention and management of chronic disease in low-income and middle-income countries: a priority for primary health care
Robert Beaglehole,JoAnne E. Epping-Jordan,Vikram Patel,Mickey Chopra,Shah Ebrahim,Michael Kidd,Andy Haines +6 more
TL;DR: To meet the challenge of chronic diseases, primary health care will have to be strengthened substantially and research on scaling-up should be embedded in large-scale delivery programmes for chronic diseases with a strong emphasis on assessment.
Journal ArticleDOI
An assessment of interactions between global health initiatives and country health systems
Badara Samb,Badara Samb,Tim Evans,Mark Dybul,Mark Dybul,Rifat Atun,Rifat Atun,Jean-Paul Moatti,Jean-Paul Moatti,Sania Nishtar,Anna Wright,Anna Wright,Francesca Celletti,Francesca Celletti,Justine Hsu,Justine Hsu,Jim Yong Kim,Jim Yong Kim,Ruairi Brugha,Ruairi Brugha,Asia Russell,Carissa F. Etienne,Carissa F. Etienne +22 more
TL;DR: This Report suggests that this Report provides the most detailed compilation of published and emerging evidence so far, and provides a basis for identification of the ways in which GHIs and health systems can interact to mutually reinforce their effects.
Journal ArticleDOI
Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity
Carmela Saturnino,Fedora Grande,Stefano Aquaro,Anna Caruso,Domenico Iacopetta,Maria Grazia Bonomo,Pasquale Longo,Dominique Schols,Maria Stefania Sinicropi +8 more
TL;DR: A preliminary biological investigation on the synthesized small series of chloro-1,4-dimethyl-9H-carbazoles shows a nitro-derivative showed the most interesting profile representing a suitable lead for the development of novel anti-HIV drugs.
Journal ArticleDOI
A retrospective cohort study: 10-year trend of disease-modifying antirheumatic drugs and biological agents use in patients with rheumatoid arthritis at Veteran Affairs Medical Centers.
TL;DR: Methotrexate use increased as it became the preferred first-line agent, while other traditional agents declined, and a significant shorter time between RA diagnosis and DMARD or biological agent initiation in recent years suggests improvements in quality of care.
References
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Journal ArticleDOI
Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries.
Paula Braitstein,Mwg Brinkhof,François Dabis,Mauro Schechter,Andrew Boulle,Paolo G. Miotti,Robin Wood,Christian Laurent,Eduardo Sprinz,Catherine Seyler,David R. Bangsberg,Eric Balestre,Jonathan A C Sterne,Margaret T May,Matthias Egger +14 more
TL;DR: Patients starting HAART in resource-poor settings have increased mortality rates in the first months on therapy, compared with those in developed countries, and timely diagnosis and assessment of treatment eligibility, coupled with free provision of HAART might reduce this excess mortality.
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Triple-Nucleoside Regimens versus Efavirenz-Containing Regimens for the Initial Treatment of HIV-1 Infection
Roy M. Gulick,Roy M. Gulick,Heather J. Ribaudo,Cecilia M. Shikuma,Stephanie Lustgarten,Kathleen Squires,William A. Meyer,Edward P. Acosta,Bruce R. Schackman,Christopher D. Pilcher,Robert L. Murphy,W E Maher,Mallory D. Witt,Richard C. Reichman,Sally Snyder,Karin L. Klingman,Daniel R. Kuritzkes +16 more
TL;DR: In this trial of the initial treatment of HIV-1 infection, the triple-nucleoside combination of abacavir, zidovudine, and lamivudine was virologically inferior to a regimen containing efavirenz and two or three nucleosides.
Journal ArticleDOI
Scaling up of highly active antiretroviral therapy in a rural district of Malawi: an effectiveness assessment.
Laurent Ferradini,Arnaud Jeannin,Loretxu Pinoges,Jacques Izopet,Didakus Odhiambo,Limangeni Mankhambo,Gloria Karungi,Elisabeth Szumilin,Serge Balandine,Gaëlle Fedida,M. Patrizia Carrieri,Bruno Spire,Nathan Ford,Jean-Michel Tassie,Philippe J Guerin,Christopher Brasher +15 more
TL;DR: These data show that large numbers of people can rapidly benefit from antiretroviral therapy in rural resource-poor settings and strongly supports the implementation of such large-scale simplified programmes in Africa.