Journal ArticleDOI
Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach–Zehnder configuration
TLDR
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach-Zehnder interferometer design is presented and a significant improvement over previously obtained results should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence.Abstract:
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach-Zehnder interferometer design is presented. The novel feature of the new design is the use of a Wollaston prism through which the phase quantities of the p and s polarizations are interrogated simultaneously. Since SPR affects only the p polarization, the signal due to the s polarization can be used as the reference. Consequently, the differential phase between the two polarizations allows us to eliminate all common-path phase noise while keeping the phase change caused by the SPR effect. Experimental results obtained from glycerin-water mixtures indicate that the sensitivity limit of our scheme is 5.5 x 10(-8) refractive-index units per 0.01 degrees phase change. To our knowledge, this is a significant improvement over previously obtained results when gold was used as the sensor surface. Such an improvement in the sensitivity limit should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence. Monitoring of the bovine serum albumin (BSA) binding reaction with BSA antibodies is also demonstrated.read more
Citations
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Journal ArticleDOI
Designing efficient zero calibration point for phase-sensitive surface plasmon resonance biosensing
Sergiy Patskovsky,Martin Vallières,Mathieu Maisonneuve,In-Hyouk Song,Michel Meunier,Andrei V. Kabashin +5 more
TL;DR: This work takes advantage of a specific angular dependence of phase of light, reflected under SPR geometry, on parameters of the SPR-supporting metal, and proposes a polarimetry-based methodology to easily determine the optimal calibration zero point, corresponding to the maximal phase sensitivity.
Journal ArticleDOI
High-sensitivity Goos-Hanchen shift sensing based on Bloch surface wave
TL;DR: In this paper, a novel and simple sensing scheme based on the giant Goos-Hanchen shift enhanced by the excitation of the Bloch surface wave in a truncated one-dimensional photonic crystal structure is proposed and experimentally demonstrated.
Journal ArticleDOI
Laser-scanning angle deviation microscopy
TL;DR: In this paper, a microscope with a dynamic range of several microns and an axial (or height) resolution of 1 nm is presented, which is based on the method of angle deviation due to nonfocal plane reflection and the application of surface plasmon resonance effect as well as the technique of heterodyne interferometry.
Journal ArticleDOI
Surface plasmon resonance imaging of excitable cells.
Carmel L. Howe,Kevin F. Webb,Sidahmed A. Abayzeed,David A. Anderson,Chris Denning,Noah A. Russell +5 more
TL;DR: The capability of the platform to perform label-free functional imaging of living cells was demonstrated by imaging the spatial variations in contractions from stem cell-derived cardiomyocytes and shows promise for non-invasive imaging of cultured cells over very long periods of time during development.
Journal ArticleDOI
Simulation of an absorption-based surface-plasmon resonance sensor by means of ellipsometry.
Tetsuo Iwata,Shogo Maeda +1 more
TL;DR: It is pointed out that introduction of an ellipsometric measurement technique to an absorption-based surface-plasmon resonance (SPR) sensor enhances precision and sensitivity in measuring the imaginary part k of the complex refractive index of the sample.
References
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Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal ArticleDOI
Surface plasmon resonance sensors: review
TL;DR: Main application areas are outlined and examples of applications of SPR sensor technology are presented and future prospects of SPR technology are discussed.
Journal ArticleDOI
Surface plasmon resonance interferometer for bio- and chemical-sensors
TL;DR: In this paper, an interferometric method for the detection of the phase shifts of reflected light under surface plasmon resonance (SPR) conditions due to refractive index changes is proposed and experimentally realized.
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Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor
TL;DR: In this article, the authors report on the performance of TI's newest surface plasmon resonance (SPR) sensor, the Spreeta 2000, measured using instruments developed by TI and by Prolinx Inc., who are developing advanced molecular interaction analysis technology utilizing a proprietary version of SPreeta2000.
Journal ArticleDOI
Surface plasmon resonance interferometry for micro-array biosensing
Petr I. Nikitin,A. N. Grigorenko,A.A. Beloglazov,M. V. Valeiko,A. I. Savchuk,O. Savchuk,Gerald Steiner,Christian Kuhne,A Huebner,Reiner Salzer +9 more
TL;DR: In this paper, the phase reveals abrupt jumps in response to a minute increase in the effective thickness of a receptor layer that binds analyte particles on the sensor surface, which forms the basis for biosensing with sensitivity much higher as compared to traditional SPR sensors.