Journal ArticleDOI
Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach–Zehnder configuration
TLDR
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach-Zehnder interferometer design is presented and a significant improvement over previously obtained results should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence.Abstract:
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach-Zehnder interferometer design is presented. The novel feature of the new design is the use of a Wollaston prism through which the phase quantities of the p and s polarizations are interrogated simultaneously. Since SPR affects only the p polarization, the signal due to the s polarization can be used as the reference. Consequently, the differential phase between the two polarizations allows us to eliminate all common-path phase noise while keeping the phase change caused by the SPR effect. Experimental results obtained from glycerin-water mixtures indicate that the sensitivity limit of our scheme is 5.5 x 10(-8) refractive-index units per 0.01 degrees phase change. To our knowledge, this is a significant improvement over previously obtained results when gold was used as the sensor surface. Such an improvement in the sensitivity limit should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence. Monitoring of the bovine serum albumin (BSA) binding reaction with BSA antibodies is also demonstrated.read more
Citations
More filters
Journal ArticleDOI
Investigation of a low cost tapered plastic fiber optic biosensor based on manipulation of colloidal gold nanoparticles
TL;DR: In this paper, a low cost Tapered Fiber Optic Biosensor (TFOBS) based on manipulation of colloidal gold nanoparticles in the evanescent field of tapered fiber is demonstrated.
Journal ArticleDOI
Investigation of the structure of iron oxide nanoparticle assemblies in order to optimize the sensitivity of surface plasmon resonance-based sensors
Mathias Dolci,Jean-François Bryche,Julien Moreau,Cédric Leuvrey,Sylvie Begin-Colin,Grégory Barbillon,Benoit P. Pichon,Benoit P. Pichon +7 more
TL;DR: In this paper, the fine control of the structure of nanoparticle assemblies is critical to optimize the sensitivity of surface plasmon resonance (SPR) biosensors based on metal thin films.
Journal ArticleDOI
Label-Free Near-Infrared Plasmonic Sensing Technique for DNA Detection at Ultralow Concentrations.
TL;DR: This work combines high bulk‐ and surface‐sensitivities, providing a simple way toward label‐free ultralow‐concentration biomolecular detection, which is a further step in label‐ free ultrasensitive sensing technique.
Journal ArticleDOI
Self-referencing SPR biosensing with an ultralow limit-of-detection using long-wavelength excitation
TL;DR: In this paper, a novel approach for surface plasmon resonance (SPR) biosensing with low limit of detection (LOD) for biomedical research and early clinical diagnostics was reported.
Journal ArticleDOI
Bulk Sensing Using a Long-Range Surface-Plasmon Dual-Output Mach–Zehnder Interferometer
Hui Fan,Pierre Berini +1 more
TL;DR: In this article, a dual-output Mach-Zehnder interferometer built from long-range surface-plasmon polariton waveguides operating at a free-space wavelength of 1375nm is demonstrated.
References
More filters
Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal ArticleDOI
Surface plasmon resonance sensors: review
TL;DR: Main application areas are outlined and examples of applications of SPR sensor technology are presented and future prospects of SPR technology are discussed.
Journal ArticleDOI
Surface plasmon resonance interferometer for bio- and chemical-sensors
TL;DR: In this paper, an interferometric method for the detection of the phase shifts of reflected light under surface plasmon resonance (SPR) conditions due to refractive index changes is proposed and experimentally realized.
Journal ArticleDOI
Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor
TL;DR: In this article, the authors report on the performance of TI's newest surface plasmon resonance (SPR) sensor, the Spreeta 2000, measured using instruments developed by TI and by Prolinx Inc., who are developing advanced molecular interaction analysis technology utilizing a proprietary version of SPreeta2000.
Journal ArticleDOI
Surface plasmon resonance interferometry for micro-array biosensing
Petr I. Nikitin,A. N. Grigorenko,A.A. Beloglazov,M. V. Valeiko,A. I. Savchuk,O. Savchuk,Gerald Steiner,Christian Kuhne,A Huebner,Reiner Salzer +9 more
TL;DR: In this paper, the phase reveals abrupt jumps in response to a minute increase in the effective thickness of a receptor layer that binds analyte particles on the sensor surface, which forms the basis for biosensing with sensitivity much higher as compared to traditional SPR sensors.