Journal ArticleDOI
Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach–Zehnder configuration
TLDR
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach-Zehnder interferometer design is presented and a significant improvement over previously obtained results should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence.Abstract:
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach-Zehnder interferometer design is presented. The novel feature of the new design is the use of a Wollaston prism through which the phase quantities of the p and s polarizations are interrogated simultaneously. Since SPR affects only the p polarization, the signal due to the s polarization can be used as the reference. Consequently, the differential phase between the two polarizations allows us to eliminate all common-path phase noise while keeping the phase change caused by the SPR effect. Experimental results obtained from glycerin-water mixtures indicate that the sensitivity limit of our scheme is 5.5 x 10(-8) refractive-index units per 0.01 degrees phase change. To our knowledge, this is a significant improvement over previously obtained results when gold was used as the sensor surface. Such an improvement in the sensitivity limit should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence. Monitoring of the bovine serum albumin (BSA) binding reaction with BSA antibodies is also demonstrated.read more
Citations
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Journal ArticleDOI
Noise Cancellation in Long-Range Surface Plasmon Dual-Output Mach-Zehnder Interferometers
Hui Fan,Pierre Berini +1 more
TL;DR: In this article, a dual-output Mach-Zehnder interferometer operating with long-range surface plasmon-polaritons at a free-space wavelength of ~1370 nm is reported.
Journal ArticleDOI
Detection of methane by a surface plasmon resonance sensor based on polarization interferometry and angle modulation
TL;DR: A surface plasmon resonance (SPR) sensing technique based on polarization interferometry and angle modulation is presented and a theoretical analysis shows that this technique can provide a wide linear measurement range.
Journal ArticleDOI
Phase difference mapping of two-dimensional metallic nanohole arrays
S. L. Wong,Hock Chun Ong +1 more
TL;DR: By using angle-resolved reflectivity and common-path phase quadrature interferometry, Wang et al. as mentioned in this paper measured the dispersion relations and the p-s polarization phase difference mappings of Au nanohole arrays.
Journal ArticleDOI
Optimization of high-Q coupled nanobeam cavity for label-free sensing.
TL;DR: The numerically and experimentally investigated the lateral coupling between photonic crystal (PhC) nanobeam (NB) cavities, pursuing high sensitivity and figure of merit (FOM) label-free biosensor, and it is shown that even modes are more sensitive than odd modes.
Journal ArticleDOI
Combined fibre-optic sensor for colour and refractive index (CI) monitoring
Jean-Marie Trudeau,Patrick Paradis,Claude Paré,Chiara Meneghini,A. Cournoyer,E. Savard,Gilles Doyon,A.-C. Jacob-Poulin,André Fougères +8 more
TL;DR: In this article, two fiber-optic probes are combined for the simultaneous monitoring of colour and refractive index of liquids, including highly coloured ones, and the design can be adapted to cover different ranges of refractive indices, light absorption and sensitivity.
References
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Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal ArticleDOI
Surface plasmon resonance sensors: review
TL;DR: Main application areas are outlined and examples of applications of SPR sensor technology are presented and future prospects of SPR technology are discussed.
Journal ArticleDOI
Surface plasmon resonance interferometer for bio- and chemical-sensors
TL;DR: In this paper, an interferometric method for the detection of the phase shifts of reflected light under surface plasmon resonance (SPR) conditions due to refractive index changes is proposed and experimentally realized.
Journal ArticleDOI
Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor
TL;DR: In this article, the authors report on the performance of TI's newest surface plasmon resonance (SPR) sensor, the Spreeta 2000, measured using instruments developed by TI and by Prolinx Inc., who are developing advanced molecular interaction analysis technology utilizing a proprietary version of SPreeta2000.
Journal ArticleDOI
Surface plasmon resonance interferometry for micro-array biosensing
Petr I. Nikitin,A. N. Grigorenko,A.A. Beloglazov,M. V. Valeiko,A. I. Savchuk,O. Savchuk,Gerald Steiner,Christian Kuhne,A Huebner,Reiner Salzer +9 more
TL;DR: In this paper, the phase reveals abrupt jumps in response to a minute increase in the effective thickness of a receptor layer that binds analyte particles on the sensor surface, which forms the basis for biosensing with sensitivity much higher as compared to traditional SPR sensors.