Journal ArticleDOI
Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach–Zehnder configuration
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TLDR
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach-Zehnder interferometer design is presented and a significant improvement over previously obtained results should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence.Abstract:
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach-Zehnder interferometer design is presented. The novel feature of the new design is the use of a Wollaston prism through which the phase quantities of the p and s polarizations are interrogated simultaneously. Since SPR affects only the p polarization, the signal due to the s polarization can be used as the reference. Consequently, the differential phase between the two polarizations allows us to eliminate all common-path phase noise while keeping the phase change caused by the SPR effect. Experimental results obtained from glycerin-water mixtures indicate that the sensitivity limit of our scheme is 5.5 x 10(-8) refractive-index units per 0.01 degrees phase change. To our knowledge, this is a significant improvement over previously obtained results when gold was used as the sensor surface. Such an improvement in the sensitivity limit should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence. Monitoring of the bovine serum albumin (BSA) binding reaction with BSA antibodies is also demonstrated.read more
Citations
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Journal ArticleDOI
Metallic Grating on a D-Shaped Fiber for Refractive Index Sensing
TL;DR: In this paper, a D-shaped fiber is obtained through polishing the cladding of a single-mode fiber away from one side, and a thin-film layer of gold is deposited on the flat side surface.
Journal ArticleDOI
Bandgap-assisted surface-plasmon sensing
Arnaud Benahmed,Chih-Ming Ho +1 more
TL;DR: The numerical simulation illustrates that the sensitivity, detection limit, and reflectivity minimum of an amplitude-based SPR bandgap-assisted surface-plasmon sensor are almost independent of the divergence angle.
Journal ArticleDOI
Phase detection properties of grating-coupled surface plasmon resonance sensors
Wen-Kai Kuo,Chih-Hao Chang +1 more
TL;DR: The results reveal that the phase detection sensitivity of the GCSPR sensor may be comparable to that of the PCSPRSensor, which has been studied by performing finite-difference time-domain simulation first.
Journal ArticleDOI
Measurement of air-refractive-index fluctuation from frequency change using a phase modulation homodyne interferometer and an external cavity laser diode
TL;DR: In this article, a method for air-refractive index (nair) fluctuation measurement using a laser interferometer using phase modulation homodyne interferometers (PMHI) is presented.
Journal ArticleDOI
High performing phase-based surface plasmon resonance sensing from metallic nanohole arrays
TL;DR: In this paper, the p-s polarization phase jump was found to be the sharpest when both the absorption and radiative decay rates of surface plasmon polaritons were matched, yielding an extremely small spectral differential phase linewidth.
References
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Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal ArticleDOI
Surface plasmon resonance sensors: review
TL;DR: Main application areas are outlined and examples of applications of SPR sensor technology are presented and future prospects of SPR technology are discussed.
Journal ArticleDOI
Surface plasmon resonance interferometer for bio- and chemical-sensors
TL;DR: In this paper, an interferometric method for the detection of the phase shifts of reflected light under surface plasmon resonance (SPR) conditions due to refractive index changes is proposed and experimentally realized.
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Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor
TL;DR: In this article, the authors report on the performance of TI's newest surface plasmon resonance (SPR) sensor, the Spreeta 2000, measured using instruments developed by TI and by Prolinx Inc., who are developing advanced molecular interaction analysis technology utilizing a proprietary version of SPreeta2000.
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Surface plasmon resonance interferometry for micro-array biosensing
Petr I. Nikitin,A. N. Grigorenko,A.A. Beloglazov,M. V. Valeiko,A. I. Savchuk,O. Savchuk,Gerald Steiner,Christian Kuhne,A Huebner,Reiner Salzer +9 more
TL;DR: In this paper, the phase reveals abrupt jumps in response to a minute increase in the effective thickness of a receptor layer that binds analyte particles on the sensor surface, which forms the basis for biosensing with sensitivity much higher as compared to traditional SPR sensors.