Journal ArticleDOI
Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach–Zehnder configuration
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TLDR
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach-Zehnder interferometer design is presented and a significant improvement over previously obtained results should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence.Abstract:
A high-sensitivity surface plasmon resonance (SPR) biosensor based on the Mach-Zehnder interferometer design is presented. The novel feature of the new design is the use of a Wollaston prism through which the phase quantities of the p and s polarizations are interrogated simultaneously. Since SPR affects only the p polarization, the signal due to the s polarization can be used as the reference. Consequently, the differential phase between the two polarizations allows us to eliminate all common-path phase noise while keeping the phase change caused by the SPR effect. Experimental results obtained from glycerin-water mixtures indicate that the sensitivity limit of our scheme is 5.5 x 10(-8) refractive-index units per 0.01 degrees phase change. To our knowledge, this is a significant improvement over previously obtained results when gold was used as the sensor surface. Such an improvement in the sensitivity limit should allow SPR biosensors to become a possible replacement for conventional biosensing techniques based on fluorescence. Monitoring of the bovine serum albumin (BSA) binding reaction with BSA antibodies is also demonstrated.read more
Citations
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Journal ArticleDOI
Multilayered Nanoplasmonic Arrays for Self-Referenced Biosensing.
TL;DR: A new proof-of-concept multilayered LSPR sensor design that incorporates both a sensing layer and an encapsulated reference layer within the same region is presented, able to monitor and correct for sensor drift without the need for a secondary reference channel.
Journal ArticleDOI
Development and Application of Time-Resolved Surface Plasmon Resonance Spectrometer
TL;DR: In this article, the authors reviewed the development of SPR sensors and SPR commercial instruments, and emphatically introduced the time-resolved surface plasmon resonance (TR-SPR) techniques.
Journal ArticleDOI
Ultra-small v-shaped gold split ring resonators for biosensing using fundamental magnetic resonance in the visible spectrum.
Alana Mauluidy Soehartono,Aaron D. Mueller,Landobasa Y. M. Tobing,Kok Ken Chan,Dao Hua Zhang,Ken-Tye Yong +5 more
TL;DR: This work reports the first demonstration of LSPR sensing based on fundamental magnetic resonance in the visible spectrum using ultrasmall gold v-shaped split ring resonators and shows the ability for detecting adsorption of bovine serum albumin and cytochrome c biomolecules at monolayer levels, and the selective binding of protein A/G to immunoglobulin G.
Journal ArticleDOI
Phase interrogation birefringent-refraction sensor for refractive index variation measurements
Ruey-Ching Twu,Chia-Wei Hsueh +1 more
TL;DR: In this article, a birefringent-refraction (BR) sensor for measuring refractive indices of liquid solutions based on phase interrogation in a heterodyne interferometer is proposed.
Journal ArticleDOI
Surface Plasmon Resonance-Based Sensing Utilizing Spatial Phase Modulation in an Imaging Interferometer.
TL;DR: The results suggest that the SPR interferometer with the detection of a fringe phase shift is particularly useful in applications that require measuring refractive index changes with high sensitivity.
References
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Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal ArticleDOI
Surface plasmon resonance sensors: review
TL;DR: Main application areas are outlined and examples of applications of SPR sensor technology are presented and future prospects of SPR technology are discussed.
Journal ArticleDOI
Surface plasmon resonance interferometer for bio- and chemical-sensors
TL;DR: In this paper, an interferometric method for the detection of the phase shifts of reflected light under surface plasmon resonance (SPR) conditions due to refractive index changes is proposed and experimentally realized.
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Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor
TL;DR: In this article, the authors report on the performance of TI's newest surface plasmon resonance (SPR) sensor, the Spreeta 2000, measured using instruments developed by TI and by Prolinx Inc., who are developing advanced molecular interaction analysis technology utilizing a proprietary version of SPreeta2000.
Journal ArticleDOI
Surface plasmon resonance interferometry for micro-array biosensing
Petr I. Nikitin,A. N. Grigorenko,A.A. Beloglazov,M. V. Valeiko,A. I. Savchuk,O. Savchuk,Gerald Steiner,Christian Kuhne,A Huebner,Reiner Salzer +9 more
TL;DR: In this paper, the phase reveals abrupt jumps in response to a minute increase in the effective thickness of a receptor layer that binds analyte particles on the sensor surface, which forms the basis for biosensing with sensitivity much higher as compared to traditional SPR sensors.