Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing
Yang Zifeng,Rongkang Huang,Bingna Zheng,Guo Wentai,Chuangkun Li,Wenyi He,Yingqi Wei,Yang Du,Huaiming Wang,Dingcai Wu,Hui Wang +10 more
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TLDR
In this paper, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels.Abstract:
Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21-51 kPa), large tensile strain (899-1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long-lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long-lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.read more
Citations
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Magnesium Oxide-Assisted Dual-Cross-Linking Bio-Multifunctional Hydrogels for Wound Repair during Full-Thickness Skin Injuries
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Chitosan-based hydrogels with injectable, self-healing and antibacterial properties for wound healing
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Glucose-responsive multifunctional metal–organic drug-loaded hydrogel for diabetic wound healing
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Engineered multifunctional nanocomposite hydrogel dressing to promote vascularization and anti-inflammation by sustained releasing of Mg2+ for diabetic wounds
ShuangLi Zhu,Qiyuan Dai,Longtao Yao,Zetao Wang,Zhi Gang He,Maocai Li,Hao Wang,Qingtao Li,Huichang Gao,Xiaodong Cao +9 more
TL;DR: In this article , a bioactive hydrogel dressing with self-adaptive self-crosslinking of hyaluronic acid modified with phenyl boronate acid (HA-PBA) was developed for the treatment of diabetic ulcers.
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Multifunctional hydrogel as wound dressing for intelligent wound monitoring
TL;DR: In this article , a multifunctional hydrogel wound dressing is employed as wound dressing for intelligent wound monitoring, which not only has the functions of antibacterial, hemostatic and adhesive properties for effectively promoting wound healing, but also can realize real-time wound status monitoring (e.g., pH).
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