Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing
Yang Zifeng,Rongkang Huang,Bingna Zheng,Guo Wentai,Chuangkun Li,Wenyi He,Yingqi Wei,Yang Du,Huaiming Wang,Dingcai Wu,Hui Wang +10 more
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TLDR
In this paper, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels.Abstract:
Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21-51 kPa), large tensile strain (899-1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long-lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long-lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.read more
Citations
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A cooling-driven self-adaptive and removable hydrogel coupled with combined chemo-photothermal sterilization for promoting infected wound healing.
TL;DR: In this paper , a composite hydrogel with excellent wound shape matching and painless removability via a gel-sol phase transition is constructed through dynamic borate ester bonds between phenylboronic acid-grafted F127 (PF127) and polydopamine-coated reduced graphene oxide/silver nanoparticles (rGO@PDA/Ag NPs).
Journal ArticleDOI
Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria.
Zipeng Shen,Meifang Zhu,Yajia Huang,Jiangjiang Zhang,Yifan Wu,Yinzhen Pan,Guang Yang,Dong Wang,Ying Li,Ben Zhong Tang +9 more
TL;DR: Li et al. as discussed by the authors presented an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) as wound dressings, which had good transparency, making it easy to monitor the wound healing process through the composite membrane.
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Engineering mussel-inspired multifunctional nanocomposite hydrogels to orchestrate osteoimmune microenvironment and promote bone healing
Minhao Wu,Yeong-Her Wang,Hui-feng Liu,Feixiang Chen,Yufeng Zhang,Ping Wu,Zhouming Deng,Lin Cai +7 more
TL;DR: Wang et al. as mentioned in this paper presented the rational design of injectable and adhesive (GMAD/LP) hydrogels composed of gelatin-methacryloyl (GelMA), dopamine-grafted alginate (AD), and polydopamine-functionalized Laponite ([email protected]) nanosheets that can act as osteoimmune regulators to engineer the pro-regenerative microenvironment for personalized bone regeneration.
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Development of Electro-Conductive Composite Bioinks for Electrohydrodynamic Bioprinting with Microscale Resolution.
TL;DR: In this paper , an electro-conductive hydrogel is prepared by introducing poly (3,4-ethylene dioxythiophene): poly (styrene sulfonate) (PEDOT: PSS) into an RGD (GGGGRGDSP)-functionalized alginate and fibrin system (RAF), and then electrohydrodynamic (EHD)-bioprinted to form living tissue constructs with microscale resolution.
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Preparation of a Nanocomposite Hydrogel with High Adhesion, Toughness, and Inherent Antibacterial Properties by a One-Pot Method
TL;DR: In this article , the authors designed a material system with a synergistic effect and prepared a multifunctional nanocomposite hydrogel using a one-pot method, with N-maleyl dopamine (MDA), montmorillonite (MMT), chitosan-N-2-hydroxypropyl trimethylammonium chloride (HACC), and acrylamide as materials.
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