Journal ArticleDOI
How accurate is sperm morphology as an indicator of sperm function
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TLDR
This study aimed to evaluate the role of sperm morphology as an indicator of additional sperm functions among 114 andrology referrals and found it had a negative and significant correlation with the percentage normal spermatozoa.Abstract:
Sperm morphology has been consistently correlated with fertilisation success or failure. The clinical relevance of the percentage normal spermatozoa has been a widely discussed topic amongst infertility specialists and scientists. This study aimed to evaluate the role of sperm morphology as an indicator of additional sperm functions among 114 andrology referrals. The sperm functions that were investigated included chromatin packaging quality (CMA3 test (n = 109), zona-induced acrosome reaction (ZIAR test; n = 36), hemizona assay (HZI; n = 36) and progressive motility (n = 47). Chromatin packaging quality had a negative and significant (P = 0.0001, r = -0.74) correlation with the percentage normal spermatozoa, while progressive motility had a significant and positive correlation (P = 0.0001, 0.59). Accurate sperm morphology scoring as described by the WHO 2010 manual can therefore be used as an indicator of specific sperm functions.read more
Citations
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Journal ArticleDOI
Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017.
TL;DR: Sperm morphology assessment has very poor sensitivity and specificity in the diagnosis of infertility and in assisted reproductive technology, and there is very little evidence that indices of multiple sperm defects [sperm deformity index, teratozoospermia index, and multiple abnormalities index] are relevant.
Journal ArticleDOI
Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility.
TL;DR: The MiOXSYS System introduces a new strategy to detect OS by measuring the oxidation-reduction potential (ORP)--a direct evaluation of the redox balance between ROS and antioxidants.
Journal ArticleDOI
Oxidation-reduction potential and sperm DNA fragmentation, and their associations with sperm morphological anomalies amongst fertile and infertile men.
Ahmad Majzoub,M Arafa,Mohamed Mahdi,Ashok Agarwal,Sami Al Said,Ibrahim Al-Emadi,Walid El Ansari,Walid El Ansari,Walid El Ansari,Alia Alattar,Khalid Al Rumaihi,Haitham Elbardisi +11 more
TL;DR: A direct inverse relationship exists between seminal ORP and SDF with various levels of normal sperm morphology and using these measures in conjunction with standard semen morphology analysis could validate the result of the fertility status of patients.
Journal ArticleDOI
Automatic detection and segmentation of sperm head, acrosome and nucleus in microscopic images of human semen smears
TL;DR: It is shown that using active contours can improve the segmentation results of sperm heads, and a complete framework for sperm detection and segmentation which is totally automatic is presented.
Journal ArticleDOI
Continued existence of significant disparities in the technical practices of sperm morphology assessment and the clinical implications: results of a French questionnaire
TL;DR: There is a marked lack of uniformity in French laboratories for performing sperm morphology assessment and in the use of the results by physicians, and regular quality control procedures and well-trained personnel are clearly indispensable.
References
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Journal ArticleDOI
Sperm morphologic features as a prognostic factor in in vitro fertilization.
Thinus F. Kruger,Roelof Menkveld,F. S. H. Stander,Carl Lombard,Jacobus P. Van der Merwe,Johannes A. van Zyl,Karen Smith +6 more
TL;DR: In this article, the authors conducted a prospective study in women with bilateral tubal damage to determine whether there is a prognostic value in the percentage normal sperm morphologic features in a human in vitro fertilization (IVF) program.
Journal ArticleDOI
Predictive value of abnormal sperm morphology in in vitro fertilization
Thinus F. Kruger,Anibal A. Acosta,Anibal A. Acosta,K.F. Simmons,K.F. Simmons,R.J. Swanson,R.J. Swanson,J.F. Matta,J.F. Matta,Sergio Oehninger,Sergio Oehninger +10 more
TL;DR: By evaluating sperm morphology with the proposed strict criteria, its predictive value in in vitro fertilization is enhanced.
Journal ArticleDOI
Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners
Jens Peter Bonde,Erik Ernst,Tina Kold Jensen,Niels Henrik Hjollund,Henrik A Kolstad,Thomas H. Scheike,Aleksander Giwercman,Niels E. Skakkebæk,Tine Brink Henriksen,Jørn Olsen +9 more
TL;DR: The study suggests that the current WHO guidelines for normal semen quality should be used with caution, as some men with sperm counts above the lower limit of the normal range defined by WHO may in fact be subfertile.
Journal ArticleDOI
The evaluation of morphological characteristics of human spermatozoa according to stricter criteria
TL;DR: It can be concluded that the method developed in the laboratory and which resulted in the use of stricter criteria for the evaluation of sperm morphology is a practical, reliable and repeatable method and has a good prognostic value for the prediction of expected IVF fertilization, the hamster test and hemizona assay.
Journal ArticleDOI
The hemizona assay (HZA): development of a diagnostic test for the binding of human spermatozoa to the human hemizona pellucida to predict fertilization potential * † ‡
Lani J. Burkman,Charles C. Coddington,Daniel R. Franken,Thinus F. Kruger,Zev Rosenwaks,Gary D. Hodgen +5 more
TL;DR: Sperm from fertile men exhibited significantly higher binding capacity to hemizonae compared with sperm from men who had fertilization failure during in vitro fertilization (IVF) treatment, demonstrating that the HZA may be a useful diagnostic tool in male infertility evaluations.