Journal ArticleDOI
How do you feel? Interoception: the sense of the physiological condition of the body.
TLDR
Functional anatomical work has detailed an afferent neural system in primates and in humans that represents all aspects of the physiological condition of the physical body that might provide a foundation for subjective feelings, emotion and self-awareness.Abstract:
As humans, we perceive feelings from our bodies that relate our state of well-being, our energy and stress levels, our mood and disposition. How do we have these feelings? What neural processes do they represent? Recent functional anatomical work has detailed an afferent neural system in primates and in humans that represents all aspects of the physiological condition of the physical body. This system constitutes a representation of 'the material me', and might provide a foundation for subjective feelings, emotion and self-awareness.read more
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Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control
William W. Seeley,Vinod Menon,Alan F. Schatzberg,Jennifer Keller,Gary H. Glover,Heather A. Kenna,Allan L. Reiss,Michael D. Greicius +7 more
TL;DR: Two distinct networks typically coactivated during functional MRI tasks are identified, anchored by dorsal anterior cingulate and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an “executive-control network” that links dorsolateral frontal and parietal neocortices.
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From inflammation to sickness and depression: when the immune system subjugates the brain
TL;DR: In response to a peripheral infection, innate immune cells produce pro-inflammatory cytokines that act on the brain to cause sickness behaviour, which can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals.
Journal ArticleDOI
How do you feel--now? The anterior insula and human awareness.
TL;DR: New findings suggest a fundamental role for the AIC (and the von Economo neurons it contains) in awareness, and thus it needs to be considered as a potential neural correlate of consciousness.
Journal ArticleDOI
Saliency, switching, attention and control: a network model of insula function
Vinod Menon,Lucina Q. Uddin +1 more
TL;DR: It is suggested that this framework provides a parsimonious account of insula function in neurotypical adults, and may provide novel insights into the neural basis of disorders of affective and social cognition.
Journal ArticleDOI
Meeting of minds: the medial frontal cortex and social cognition.
David M. Amodio,Chris D. Frith +1 more
TL;DR: This work reviews the emerging literature that relates social cognition to the medial frontal cortex and proposes a theoretical model of medial frontal cortical function relevant to different aspects of social cognitive processing.
References
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Journal ArticleDOI
Central Pain-A Neurosurgical Challenge
TL;DR: In this text, Professor Pagni attempts to define, classify, and review critically the multitude of treatments that have been proposed for central pain.
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Spike generation from dorsal roots and cutaneous afferents by hypoxia or hypercapnia in the rat in vivo.
TL;DR: It is concluded that central and peripheral terminals but not axons of primary afferent neurones are excited by a brief hypoxia or hypercapnia and the peripheral terminals by a short local ischaemia as well.
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Neuronal application of capsaicin modulates somatic pressor reflexes.
J. F. LeDoux,L. B. Wilson +1 more
TL;DR: The results show that the reflex cardiovascular increases evoked by static muscle contraction and noxious input are differentially affected by Cap application to the common peroneal nerve.