How I treat mucormycosis
TLDR
The subtle clinical and radiographic clues that should alert the hematologist to the possibility of mucormycosis, and aggressive and timely treatment approaches that may limit the spread of infection before it becomes fatal are described.About:
This article is published in Blood.The article was published on 2011-08-04 and is currently open access. It has received 280 citations till now. The article focuses on the topics: Mucormycosis & Posaconazole.read more
Citations
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Journal ArticleDOI
Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium
Oliver A. Cornely,Ana Alastruey-Izquierdo,Dorothee Arenz,Sharon C.-A. Chen,Eric Dannaoui,Bruno Hochhegger,Bruno Hochhegger,Martin Hoenigl,Martin Hoenigl,Henrik Jeldtoft Jensen,Katrien Lagrou,Russell E. Lewis,Sibylle C. Mellinghoff,Mervyn Mer,Zoi D. Pana,Danila Seidel,Donald C. Sheppard,Roger Wahba,Murat Akova,Alexandre Alanio,Abdullah M. S. Al-Hatmi,Sevtap Arikan-Akdagli,Hamid Badali,Ronen Ben-Ami,Alexandro Bonifaz,Stéphane Bretagne,Elio Castagnola,Methee Chayakulkeeree,Arnaldo Lopes Colombo,Dora E. Corzo-Leon,Lubos Drgona,Andreas H. Groll,Jesús Guinea,Jesús Guinea,Claus Peter Heussel,Ashraf S. Ibrahim,Souha S. Kanj,Nikolay Klimko,Michaela Lackner,Frédéric Lamoth,Fanny Lanternier,Cornelia Lass-Floerl,Dong-Gun Lee,Thomas Lehrnbecher,Badre E. Lmimouni,Mihai Mares,Georg Maschmeyer,Jacques F. Meis,Joseph Meletiadis,Joseph Meletiadis,C. Orla Morrissey,Marcio Nucci,Rita O. Oladele,Livio Pagano,Alessandro C. Pasqualotto,Atul Patel,Zdenek Racil,Malcolm Richardson,Emmanuel Roilides,Markus Ruhnke,Seyedmojtaba Seyedmousavi,Seyedmojtaba Seyedmousavi,Neeraj Sidharthan,Nina Singh,Janos Sinko,Anna Skiada,Monica A. Slavin,Monica A. Slavin,Rajeev Soman,Brad Spellberg,William J. Steinbach,Ban Hock Tan,Andrew J. Ullmann,Joerg J. Vehreschild,Maria J G T Vehreschild,Thomas J. Walsh,P. Lewis White,Nathan P. Wiederhold,Theoklis E. Zaoutis,Arunaloke Chakrabarti +79 more
TL;DR: Management of mucormycosis depends on recognising disease patterns and on early diagnosis, and limited availability of contemporary treatments burdens patients in low and middle income settings.
Journal ArticleDOI
The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports.
Wirawan Jeong,Caitlin Keighley,Caitlin Keighley,Rory Wolfe,W.L. Lee,Monica A. Slavin,Monica A. Slavin,David C. M. Kong,Sharon C.-A. Chen,Sharon C.-A. Chen +9 more
TL;DR: Findings from the current review have helped ascertain the association between various manifestations of mucormycosis, their respective predisposing factors and causative organisms.
Journal ArticleDOI
Epidemiology and Diagnosis of Mucormycosis: An Update
TL;DR: The epidemiology of mucormycosis is evolving as new immunomodulating agents are used in the treatment of cancer and autoimmune diseases, and as the modern diagnostic tools lead to the identification of previously uncommon genera/species such as Apophysomyces or Saksenaea complex.
Journal ArticleDOI
Necrotizing cutaneous mucormycosis after a Tornado in Joplin, Missouri, in 2011
Robyn Neblett Fanfair,Kaitlin Benedict,John Bos,Sarah D. Bennett,Yi-Chun Lo,Tolu Adebanjo,Kizee A. Etienne,Eszter Deak,Gordana Derado,Wun Ju Shieh,Clifton P. Drew,Sherif R. Zaki,David E. Sugerman,Lalitha Gade,Elizabeth H. Thompson,Deanna A. Sutton,David M. Engelthaler,James M. Schupp,Mary E. Brandt,Julie R. Harris,Shawn R. Lockhart,George Turabelidze,Benjamin J. Park +22 more
TL;DR: A cluster of cases of cutaneous mucormycosis among Joplin tornado survivors that were associated with substantial morbidity and mortality are reported and increased awareness of fungi as a cause of necrotizing soft-tissue infections after a natural disaster is warranted.
Journal ArticleDOI
Mucormycosis in Organ and Stem Cell Transplant Recipients
Fanny Lanternier,Fanny Lanternier,Hsin-Yun Sun,Hsin-Yun Sun,Patricia Ribaud,Nina Singh,Dimitrios P. Kontoyiannis,Olivier Lortholary +7 more
TL;DR: Mucormycosis refers to a group of potentially lethal opportunistic mycoses that occur in immunocompromised or diabetic patients and are caused by Mucorales, ubiquitous filamentous fungi with broad, thin-walled, sparsely septate, ribbon-like hyphae as discussed by the authors.
References
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Book
Principles and Practice of Infectious Diseases
TL;DR: This updated and expanded edition now offers 297 chapters that cover the basic principles of diagnosis and management, major clinical syndromes, all important pathogenic microbes and the diseases they cause, plus a number of specialised topics useful to the practitioner.
Journal ArticleDOI
Epidemiology and Outcome of Zygomycosis: A Review of 929 Reported Cases
Maureen Roden,Theoklis E. Zaoutis,Wendy Buchanan,Tena A. Knudsen,Tatyana A. Sarkisova,Robert L. Schaufele,Michael Sein,Tin Sein,Christine C. Chiou,Jaclyn H. Chu,Dimitrios P. Kontoyiannis,Thomas J. Walsh +11 more
TL;DR: Outcome from zygomycosis varies as a function of the underlying condition, site of infection, and use of antifungal therapy; however, infection due to Cunninghamella species and dissemination were independently associated with increased rates of death.
Journal ArticleDOI
Zygomycetes in Human Disease
TL;DR: The Mucorales are associated with angioinvasive disease, often leading to thrombosis, infarction of involved tissues, and tissue destruction mediated by a number of fungal proteases, lipases, and mycotoxins.
Journal ArticleDOI
Novel Perspectives on Mucormycosis: Pathophysiology, Presentation, and Management
Brad Spellberg,Brad Spellberg,John E. Edwards,John E. Edwards,Ashraf S. Ibrahim,Ashraf S. Ibrahim +5 more
TL;DR: It is raised the possibility that iron chelator therapy may be useful to treat the infection as long as the chelator does not inappropriately supply the fungus with iron.
Book
Medically Important Fungi: A Guide to Identification
TL;DR: A guide to interpretation of direct microscopic examination of clinical specimens and a detailed description of filamentous bacteria Yeasts and yeastlike fungi in culture.
Related Papers (5)
Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Ben E. De Pauw,Thomas J. Walsh,J. Peter Donnelly,David A. Stevens,John E. Edwards,Thierry Calandra,Peter G. Pappas,Johan Maertens,Olivier Lortholary,Carol A. Kauffman,David W. Denning,Thomas F. Patterson,Georg Maschmeyer,Jacques Bille,William E. Dismukes,Raoul Herbrecht,William W. Hope,Christopher C. Kibbler,Bart Jan Kullberg,Kieren A. Marr,Patricia Muñoz,Frank C. Odds,John R. Perfect,Angela Restrepo,Markus Ruhnke,Brahm H. Segal,Jack D. Sobel,Tania C. Sorrell,Claudio Viscoli,John R. Wingard,Theoklis E. Zaoutis,John E. Bennett +31 more